Process of preparing 2-(imidazolin-2-yl)-nicotinic acid compounds

ABSTRACT

The invention relates to processes for the preparation of 6-substituted 2-(imidazolin-2-yl)-nicotinic acid derivatives that are distinguished by excellent herbicidal and plant growth-regulating properties, and to intermediates and processes for the preparation of the intermediates. The derivatives correspond to formula I ##STR1## in which R 1  represents hydrogen or a salt, ester or amide radical, 
     each of R 2  and R 3 , independently of the other, represents C 1  -C 4  -alkyl or they together represent a C 3  -C 5  -alkylene radical, 
     X represents hydrogen or methyl, 
     Y represents hydrogen, halogen, alkyl, haloalkyl, hydroxyalkyl, alkoxy, alkylthio, phenoxy, nitro, cyano, alkylamino, phenyl, alkenyloxy or alkynyloxy, and 
     Z represents a --CQ 1  Q 2  Q 3  or --CQ 1  Q 4  Q 5  radical in which 
     Q 1  and Q 2  each represents hydrogen or C 1  -C 4  -alkyl, 
     Q 3  represents C 1  -C 6  -alkoxy or phenoxy that is unsubstituted or substituted, or C 3  -C 6  -alkenyloxy or C 3  -C 6  -alkynyloxy and 
     Q 4  and Q 5 , together with the carbon atom to which they are bonded, represent a cycloalkyl, furyl, pyran, dioxan or dioxolan radical, or 
     Z represents a 5- or 6-membered heterocyclic radical.

This is a division of application Ser. No. 206,552, filed on June 14, 1988, now abandoned.

The present invention relates to processes for the preparation of 6-substituted 2-(imidazolin-2-yl)-nicotinic acid derivatives having herbicidal and plant growth-regulating activity, and to intermediates and processes for the preparation of the intermediates.

The derivatives to be prepared are 6-substituted 2-(imidazolin-2-yl)-nicotinic acid derivatives of formula I ##STR2## in which R₁ represents hydrogen, the cation equivalent of an alkali metal, alkaline earth metal, magnesium, copper, iron, zinc, cobalt, lead, silver, nickel or quaternary ammonium or alkylammonium salt, C₁ -C₆ -alkyl unsubstituted or substituted by halogen, hydroxy, C₁ -C₃ -alkoxy, C₃ -C₆ -cycloalkyl, benzyloxy, furyl, phenyl, halophenyl, lower alkylphenyl, lower alkoxyphenyl, nitrophenyl, carboxy, C₁ -C₄ -alkoxycarbonyl or by cyano; C₃ -C₆ -cycloalkyl unsubstituted or mono- or di-substituted by C₁ -C₃ -alkyl; C₃ -C₆ -alkenyl unsubstituted or substituted by halogen, C₁ -C₃ -alkoxy, phenyl or by C₁ -C₄ -alkoxycarbonyl; or C₃ -C₆ -alkynyl unsubstituted or mono- or di-substituted by C₁ -C₃ -alkyl;

R₂ represents C₁ -C₄ -alkyl,

R₃ represents C₁ -C₄ -alkyl or C₃ -C₆ -cycloalkyl, or

R₂ and R₃, together with the carbon atom to which they are bonded, also represent a C₃ -C₆ -cycloalkyl radical which may be substituted by methyl radicals,

X represents hydrogen or methyl,

Y represents hydrogen, halogen, C₁ -C₆ -alkyl, C₁ -C₆ -haloalkyl, C₁ -C₆ -hydroxyalkyl, C₁ -C₆ -alkoxy, C₁ -C₆ -alkylthio, phenoxy, nitro, cyano, C₁ -C₄ -alkylamino, di-C₁ -C₄ -alkylamino, C₁ -C₄ -alkylsulphonyl, phenyl, halophenyl, lower alkylphenyl, lower alkoxyphenyl, C₃ -C₈ -alkenyloxy, C₃ -C₈ -haloalkenyloxy, C₃ -C₈ -alkynyloxy or C₃ -C₈ -haloalkynyloxy and

Z represents a --CQ₁ Q₂ Q₃ or --CQ₁ Q₄ Q₅ radical in which

Q₁ represents hydrogen or C₁ -C₄ -alkyl,

Q₂ represents hydrogen or C₁ -C₄ -alkyl,

Q₃ represents C₁ -C₆ -alkoxy that is unsubstituted or is substituted by C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₄ -C₉ -alkoxyalkoxy, cyano or by carbamoyl; phenoxy that is unsubstituted or is substituted by halogen, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl or by nitro; or C₃ -C₆ -alkenyloxy or C₃ -C₆ -alkynyloxy,

Q₄ and Q₅, together with the carbon atom to which they are bonded, represent C₃ -C₆ -cycloalkyl, or a 5- or 6-membered ring containing one oxygen atom or two oxygen atoms that are not vicinal, each of which radicals may be substituted by C₁ -C₄ -alkyl, or

Z represents a 5- or 6-membered, saturated or unsaturated, heterocyclic radical that is bonded by way of carbon and is unsubstituted or is substituted by lower alkyl.

In these definitions, the alkyl and also the alkenyl and alkynyl radicals may be either straight-chain or branched.

The alkyl radicals may be methyl, ethyl, n-propyl, isopropyl, n-butyl, sec.-butyl, tert.-butyl, isobutyl, n-pentyl, isopentyl, neopentyl, tert.-pentyl, n-hexyl or isohexyl. Lower alkyl and lower alkoxy denote that the alkyl radicals contain from 1 to 4 carbon atoms.

"Lower alkyl" indicates an alkyl radical having from 1 to 4 carbon atoms.

The alkenyl and alkynyl radicals preferably have from 3 to 6 carbon atoms and may be represented by the following radicals: allyl, methallyl, propynyl, 2-butenyl, 1,3-butadienyl, 1-methylvinyl, pentenyl, butynyl, pentynyl.

Halogen indicates fluorine, chlorine, bromine and iodine. The 5- or 6-membered heterocyclic radicals include, for example, furan, tetrahydrofuran, thiophene, pyrrole, pyrrolidine, oxazole, oxazolidine, triazole, imidazole, oxadiazole, thiadiazole, triazole, pyran, pyridine, piperidine, dioxan, pyrimidine, morpholine, thiomorpholine and triazine.

Compounds of this kind, that is to say 2-(imidazolin-2-yl)-nicotinic acids and also 2-imidazolyl-3-quinonecarboxylic acids and their derivatives, are known; see, for example, EP-A No. 41 623, U.S. Pat. No. 4,518,780, EP-A No. 61 423 or U.S. Pat. No. 4,647,301.

2-(Imidazolin-2-yl)-nicotinic acid derivatives are known and some 6-substituted derivatives are known. They are, however, very difficult to produce, and substitution has involved only a lower alkyl or fused phenyl radical. The compounds with the defined substituents Z are prepared by first of all introducing the substituent Z into a pyridine-2,3-dicarboxylic acid diester in accordance with one of the processes described in EP-A No. 169 051, and producing the 2-(imidazolin-2-yl)-nicotinic acid derivatives therefrom in accordance, for example, with the process known from EP-A No. 41 623.

The introduction of substituents into the 6-position of 2-imidazolyl-nicotinic acid, and the preparation of such acids and esters, has hitherto not been successful, or has been successful only with difficulty.

Good activity is exhibited by those compounds of formula I ##STR3## in which R₁ represents hydrogen or C₁ -C₆ -alkyl, R₂, R₃ and X are as defined for formula I, Y represents hydrogen, C₁ -C₆ -alkyl or halogen, Z is a heterocyclic radical or, if it represents --CQ₁ Q₂ Q₃, is a C₁ -C₆ -alkoxy-, C₁ -C₄ -alkyl-, phenoxy-C₁ -C₄ -alkyl or carbamoyl-C₁ -C₄ -alkoxyalkyl radical or, if it represents --CQ₁ Q₄ Q₅, is a C₃ -C₆ -cycloalkyl radical that may be substituted by C₁ -C₄ -alkyl.

Those compounds of formula I ##STR4## in which R₁ represents hydrogen or C₁ -C₆ -alkyl, R₂ represents methyl, R₃ represents isopropyl, X represents hydrogen or methyl, Y represents C₁ -C₆ -alkyl, chlorine or bromine and Z represents a C₁ -C₆ -alkoxyalkyl-, phenoxy-C₁ -C₄ -alkyl-carbamoyl-C₁ -C₄ -alkoxy-C₁ -C₄ -alkyl, an unsubstituted or C₁ -C₄ -alkyl-substituted C₃ -C₆ -cycloalkyl-, a thiophenyl-, pyridinyl-, methylpyrimidine-furanyl- or dioxanyl-radical, were especially active.

Even if such compounds have been described, scarcely any substituent other than a lower alkyl radical or a benzo-fused phenyl radical has been postulated for the 6-position.

It is therefore an object of the present invention to provide a process for the preparation of 2-(imidazolin-2-yl)-nicotinic acids of formula I that uses readily accessible and easily manipulable starting materials and makes it possible for these compounds to be produced in a simple manner and in a good yield.

According to a first process it is proposed that the 6-substituted 2-(imidazolin-2-yl)-nicotinic acid derivatives of formula I be prepared as follows: a 6-substituted pyridine-2,3-dicarboxylic acid diester of formula V ##STR5## in which R₁, X and Y are as defined for formula I and R₄ represents a C₁ -C₈ -alkylphenyl radical or a phenyl-C₁ -C₄ -alkyl radical, is reacted in aqueous solution, in the presence of a catalytic amount of silver(II) ions and a peroxysulphate salt, with a carboxylic acid of formula XVII

    Z--COOH                                                    (XVII),

in which Z is as defined for formula I, to yield a 6-substituted pyridine-2,3-dicarboxylic acid diester of formula IV ##STR6## in which R₁, R₄, X, Y and Z are as defined for formula I, and this ester is reacted in an inert organic solvent, in the presence of a strong base, with a 2-aminoalkanecarboxylic acid amide of formula XV ##STR7## in which R₂ and R₃ are as defined for formula I, the resulting salt of the 2-(imidazolin-2-yl)-nicotinic acid of formula III is taken up in aqueous acidic solution, the free 2-(imidazolin-2-yl)-nicotinic acid of formula III ##STR8## in which R₂, R₃, X, Y and Z are as defined for formula I, is isolated and then rearranged with a water-removing agent or reagent to form a tricyclic 2H-imidazo- [1',2':1,2]pyrrolo[3,4-b]pyridine-3,5-dione compound of formula II ##STR9## in which R₂, R₃, X, Y and Z are as defined for formula I, and this compound is then cleaved at elevated temperature with a hydroxide or alcohol of formula XVI

    HOR.sub.1                                                  (XVI),

in which R₁ is as defined for formula I, to yield the 2-(imidazolin-2-yl)-nicotinic acid derivative of formula I.

The 2-(imidazolin-2-yl)-nicotinic acid of formula III and its salts fall within the scope of the general formula I. They, too, have extraordinary herbicidal and plant growth-regulating activity. These compounds and their preparation from the pyridine-2,3-dicarboxylic acid diesters of formula V in accordance with the above-described process also form part of this invention.

The 6-substituted pyridine-2,3-dicarboxylic acid diesters of formula IV are novel intermediates. These compounds and their preparation from the pyridine-2,3-dicarboxylic acid diesters of formula V by the addition of a carboxylic acid of formula XVII in the presence of silver ions and a peroxysulphate salt to a 6-unsubstituted pyridine-2,3-dicarboxylic acid diester of formula V also form a part of this invention.

The pyridine-2,3-dicarboxylic acid esters of formula V required as starting materials can be prepared in a simple manner by esterifying pyridine-2,3-dicarboxylic acid with corresponding alcohols. The pyridine-2,3-dicarboxylic acid can itself be prepared by the oxidation of quinoline (cf. DE-PS No. 1 010 524 and U.S. Pat. No. 2,512,482). The pyridine-2,3-dicarboxylic acid esters of formula V can also be prepared in accordance with the methods described in published European Patent Applications Nos. 0 161 221 and 0 172 140 starting from a hydrazone of an α,β-unsaturated carbonyl compound and a maleic acid derivative according to a Diels-Alder reaction scheme. Quinoline-2,3-dicarboxylic acid esters not substituted in the 6-position can be obtained, for example, by the method described in J. Org. Chem. 49, 4999-5000, 1984.

The majority of the 2-aminoalkanecarboxylic acid amides of formula X are known compounds which can be prepared in known manner by reacting corresponding ketones with ammonia and hydrocyanic acid.

The substituent Z is introduced into the 6-position of the pyridine ring by means of a carboxylic acid Z--COOH in which Z corresponds to the desired substitution radical. The addition reaction is carried out in accordance with a process described in EP-A No. 169 051 for pyridazine compounds, in the presence of one equivalent of peroxysulphate ion and a catalytic amount of silver ions in an aqueous solution of mineral acid at temperatures of from 40° to 80° C. Care must be taken that the mineral acid does not precipitate the silver ions. Suitable mineral acids are, for example, sulphuric acid, perchloric acid and trifluoroacetic acid. The silver ions may originate from a water-soluble silver salt, such as silver nitrate, silver fluoride, silver trifluoroacetate or silver perchlorate, but preferably originate from silver nitrate.

In the reaction, the carboxylic acid Z--COOH is oxidatively decarboxylated, the silver(I) ions originating from the silver salt being oxidised in the presence of the peroxydisulphate salt to silver(II) ions. The reaction proceeds selectively, so that only stoichiometric amounts of carboxylic acid and peroxysulphate salt should be employed. The reaction temperature is in the range of from 40° to 80° C., preferably 70° to 80° C. The preferred peroxydisulphate salts are ammonium, sodium and potassium salts.

If, in this reaction, X represents hydrogen, then there are also formed during the radical alkylation 4- and 4,6-substituted pyridine-2,3-dicarboxylic acid esters in accordance with the following equation: ##STR10## Such ester mixtures can be separated into their components by chromatography or fractional distillation.

Suitable carboxylic acids of formula XVIII are, for example, pivalic acid (trimethylacetic acid), butyric acid, isobutyric acid, propionic acid, acetic acid, cyclobutanecarboxylic acid, cyclopropanecarboxylic acid, cyclopentenecarboxylic acid, phenoxyacetic acid and glycolic acid.

The reaction of the 6-substituted pyridine-2,3-dicarboxylic acid ester of formula IV with a 2-aminoalkanecarboxylic acid amide of formula H₂ N--C(R₂)R₃ --CONH₂ is effected in an inert organic solvent in the presence of a strong base in a temperature range of from room temperature to the reflux temperature of the reaction mixture.

Suitable inert solvents are, for example, liquid aromatic hydrocarbons and halogenated hydrocarbons, such as benzene, toluene, chlorobenzene and xylenes, C₁ -C₁₀ -alkanols, especially C₁ -C₄ -alkanols, such as methanol, ethanol, propanol, isopropanol, n-butanol, sec.-butanol, tert.-butanol and isobutanol, ethereal liquids, such as tetrahydrofuran and dioxan, and also strongly polar solvents, such as acetonitrile, N,N-dimethylformamide and dimethyl sulphoxide. Advantageously, water-immiscible solvents are used, such as benzene, toluene, chlorobenzene or xylenes.

Suitable strong bases in the presence of which the reaction of the pyridine-2,3-dicarboxylic acid ester of formula IV with a 2-aminoalkanecarboxylic acid amide of formula XV is carried out are alkali metal hydroxides and alkali metal alcoholates. Preferred bases are alkali metal alcoholates, especially those that are derived from C₁ -C₄ -alkanols, such as sodium methoxide, sodium ethoxide, sodium isopropoxide and potassium tert.-butoxide. Alkali metal hydroxides, such as sodium hydroxide and potassium hydroxide, are especially suitable when using alkanols as inert solvents. The reaction can furthermore be carried out in the presence of potash in ethanol. The strong base is normally used in at least an equimolar amount based on the pyridine-2,3-dicarboxylic acid ester of formula IV used. In carrying out the process of the invention, the use of from 1 to 3 mols of base per mol of pyridine-2,3-dicarboxylic acid ester of formula IV has proved suitable. Preferably, from 1.5 to 2.5 mol of base are used per mol of pyridine-2,3-dicarboxylic acid ester of formula IV.

Within the quoted temperature range of from room temperature to the reflux temperature of the reaction mixture, temperatures of from 50° to 90° C. are preferred for carrying out the process of the invention.

The condensation of the 2-(imidazolin-2-yl)-nicotinic acid of formula III to the tricyclic 2H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-3,5-dione of formula II is effected by means of a water-removing agent or reagent.

Such a process comprises, for example, boiling the reaction mixture on a water separator with a water-immiscible organic solvent, such as benzene or toluene, or boiling the reaction mixture in an acid anhydride or with concentrated sulphuric acid or with an organic solvent that contains either an anhydride, for example acetic anhydride, or concentrated sulphuric acid. Other suitable water-removing agents are acid halides, such as phosgene, thionyl chloride, and also other reagents, such as dicyclohexyldiimide or alternatively phosphorus pentoxide. They are preferably dissolved in organic solvents and the reaction is carried out, while stirring, at temperatures in a range of from room temperature to the boiling point of the reaction mixture.

The nomenclature of compound II, 2H-imidazo[1',2':1,2]pyrrolo[3,4-b]-pyridine-3,5-dione has been taken from Chemical Abstracts. The basic three-ring structure is designated and numbered as follows: ##STR11## In accordance with a second process, the 6-substituted 2-(imidazolin-2-yl)-nicotinic acid derivatives of formula I are prepared as follows: a 6-substituted pyridine-2,3-dicarboxylic acid diester of formula IV ##STR12## in which R₁, R₄, X, Y and Z are as defined for formula I, is hydrolysed with a strong base in aqueous medium, and the resulting 6-substituted pyridine-2,3-dicarboxylic acid of formula VI ##STR13## in which X, Y and Z are as defined for formula I, is reacted in a water-removing environment to form the 6-substituted pyridine-2,3-dicarboxylic acid anhydride of formula VII ##STR14## in which X, Y and Z are as defined for formula I, and this anhydride is then condensed with a glycylamide of formula XVIII ##STR15## in which R₂ and R₃ are as defined for formula I, and the 6-substituted 2-(N-carbamoylmethylcarbamoyl)-nicotinic acid of formula VIII ##STR16## resulting therefrom, in which R₂, R₃, X, Y and Z are as defined for formula I, is cyclised in an inert dry solvent, yielding the 6-substituted 2-(imidazolin-2-yl)-nicotinic acid of formula III ##STR17## in which R₂, R₃, X, Y and Z are as defined for formula I, which is isolated and then rearranged with a water-removing agent or reagent to form a tricyclic 2H-imidazo-[1,2:1',2']pyrrolo[3,4-b]pyridine-3,5-dione compound of formula II ##STR18## in which R₂, R₃, X, Y and Z are as defined for formula I, and this compound is then cleaved at elevated temperature with a hydroxide or alcohol of formula XVI

    HOR.sub.1                                                  (XVI),

in which R₁ is as defined for formula I, to yield the 2-(imidazolin-2-yl)-nicotinic acid derivative of formula I.

The hydrolysis of the pyridine-2,3-dicarboxylic acid diester of formula IV to the corresponding acid is a conventional hydrolysis, which is carried out with a strong base in aqueous medium at the boiling temperature of the reaction medium.

Alkali metal or alkaline earth metal hydroxides or carbonates are suitable bases, and water alone, or in admixture with an alcohol, a ketone or with dimethylformamide, is suitable as a solvent.

The reaction of the pyridine-2,3-dicarboxylic acid of formula VI to form the corresponding anhydride is carried out by boiling in a water-removing environment. Suitable water-removing media are, for example, acid anhydrides, such as, for example, acetic anhydride, and also concentrated sulphuric acid.

The addition of the glycylamide of formula XVIII to the acid anhydride of formula VII is carried out in an inert organic solvent at a temperature in the range of from room temperature to the boiling point of the solvent. The condensation of the 2-(N-carbamoylmethylcarbamoyl)nicotinic acid of formula VIII to the 2-(imidazolin-2-yl)-nicotinic acid of formula III is carried out by boiling in an inert organic solvent in the presence of a strong base under anhydrous conditions. For this preferably alkali metal alcoholates, for example potassium tert.-butoxide, are used in an alkanol as solvent.

The entire reaction, from the pyridinedicarboxylic acid diester of formula V to the 2-(imidazolin-2-yl)-nicotinic acid of formula III is preferably carried out in a one-pot process by boiling the ester, the glycylamide and the alcoholate in an inert organic solvent, such as, for example, benzene, toluene, xylene, cyclohexane, then evaporating the solvent and acidifying the residue. The nicotinic acids of formula III are obtained in pure form and free of isomers.

The process steps that lead from the 2-(imidazolin-2-yl)-nicotinic acid of formula III by way of the 2H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-3,5-dione of formula II to the 2-(imidazolin-2-yl)-nicotinic acid derivative of formula I are identical to the steps described in the first process.

According to a third process, the 6-substituted 2-(imidazolin-2-yl)-nicotinic acid derivatives of formula I are obtained as follows: a 6-substituted pyridine-2,3-dicarboxylic acid anhydride of formula VII ##STR19## in which X, Y and Z are as defined for formula I, is reacted in an inert organic solvent with a glycylnitrile of formula XIX ##STR20## in which R₂ and R₃ are as defined for formula I, the resulting 6-substituted 2-(cyanomethylcarbamoyl)-nicotinic acid of formula IX ##STR21## in which R₂, R₃, X, Y and Z are as defined for formula I, is then treated in a water-removing environment or a water-removing agent, so that an N-(cyanomethylcarbamoyl)-pyridine-2,3-dicarboxylic acid imide of formula X is obtained ##STR22## in which R₂, R₃, X, Y and Z are as defined for formula I, this imide is hydrolysed in aqueous-acidic medium, at elevated temperature, to the N-(carbamoylmethyl)-pyridine-2,3-dicarboxylic acid imide of formula XI ##STR23## in which R₂, R₃, X, Y and Z are as defined for formula I, which compound is then converted, by heating in a basic medium, into the tricyclic 3H-imidazo[1,2:1',2']pyrrolo[3,4-b]pyridine-2,5-dione compound of formula XII ##STR24## in which R₂, R₃, X, Y and Z are as defined for formula I, and this product is then cleaved at elevated temperature with a hydroxide or alcohol of formula XVI

    HOR.sub.1                                                  (XVI),

in which R₁ is as defined for formula I, to form the 2-(imidazolin-2-yl)-nicotinic acid derivative of formula I.

The condensation of the glycylnitrile of formula XIX with the pyridine-2,3-dicarboxylic acid anhydride of formula VII is carried out by stirring and heating in an inert organic solvent.

The subsequent condensation to the imide of formula X can be effected by boiling on a water separator or alternatively merely by concentrating the reaction medium by evaporation.

If the N-(glycylnitrile)-pyridine-2,3-dicarboxylic acid imide of formula X is then treated with concentrated sulphuric acid, the nitrile group is hydrolysed, yielding the N-(carbamoylmethyl)-pyridine-2,3-carboxylic acid imide of formula XI, which condenses under basic conditions to form the 3H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5-dione of formula XII. This can then be converted in the presence of a hydroxide or alcohol into the 2-(imidazolin-2-yl)-nicotinic acid derivative of formula I. These reaction steps are described, for example, in European Published Application EP-A No. 41 623.

The nomenclature of compound XII, 3H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5-dione has been taken from Chemical Abstracts. The basic three-ring structure is designated and numbered as follows: ##STR25## The 8-substituted 2H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-3,5-dione compounds of formula II and the 8-substituted 3H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5-dione compounds of formula XII are novel. They are distinguished by excellent herbicidal and plant growth-regulating activity. The invention relates also to these compounds and their preparation.

Good activity was exhibited by those compounds of formulae ##STR26## in which R₁ represents hydrogen or C₁ -C₆ -alkyl, R₂, R₃ and X are as defined for formula I, Y represents hydrogen, C₁ -C₆ -alkyl or halogen, Z is a heterocyclic radical or, if it represents --CQ₁ Q₂ Q₃, is a C₁ -C₆ -alkoxy-, C₁ -C₄ -alkyl-, phenoxy-C₁ -C₄ -alkyl or carbamoyl-C₁ -C₄ -alkoxyalkyl radical or, if it represents --CQ₁ Q₄ Q₅, is a C₃ -C₆ -cycloalkyl radical that may be substituted by C₁ -C₄ -alkyl.

Most especially active were those compounds of formulae ##STR27## in which R₁ represents hydrogen or C₁ -C₆ -alkyl, R₂ represents methyl, R₃ represents isopropyl, hydrogen or methyl, Y represents C₁ -C₆ -alkyl, chlorine or bromine and Z represents a C₁ -C₆ -alkoxyalkyl-, phenoxy-C₁ -C₄ -alkyl-carbamoyl-C₁ -C₄ -alkoxy-C₁ -C₄ -alkyl, an unsubstituted or C₁ -C₄ -alkyl-substituted C₃ -C₆ -cycloalkyl-, a thiophenyl-, pyridinyl-, methylpyrimidine-furanyl- or dioxanyl-radical.

The 6-substituted 2-(cyanomethylcarbamoyl)-nicotinic acids of formula IX, the N-(cyanomethylcarbamoyl)-pyridine-2,3-dicarboxylic acid imides of formula X and the N-(carbamoylmethyl)-pyridinedicarboxylic acid imides of formula XI are novel intermediates. The invention also relates to these compounds and to the preparation thereof.

According to another process, the 6-substituted 2-(imidazolin-2-yl)-nicotinic acid derivatives of formula I are prepared as follows: a methyl ketone of formula XXIV

    Z--COCH.sub.3                                              (XXIV),

in which Z is as defined for formula I, is reacted with a secondary amine of formula XX ##STR28## in which R₅ represents C₁ -C₄ -alkyl or phenyl-C₁ -C₄ -alkyl, or the two R₅ radicals, together with the nitrogen atom to which they are bonded, form a 5- or 6-membered, saturated or unsaturated ring that may be interrupted by oxygen, the resulting methyleneamine of formula XXI ##STR29## in which R₅ is as defined above, is then condensed with an alkoxymethyleneoxalacetic ester of formula XXII ##STR30## in which each of the R₆ radicals, independently of the others, represents a C₁ -C₆ -alkyl or phenyl-C₁ -C₆ -alkyl radical, resulting in a 6-amino-3-alkoxycarbonyl-hexane-3,5-dienecarboxylic acid ester of formula XXIII ##STR31## in which R₅ and R₆ have the meanings given above and Z is as defined for formula I, this ester is then cyclised with ammonia in organic solution to yield the 6-substituted pyridine-2,3-dicarboxylic acid diester of formula IVa ##STR32## in which Z is as defined for formula I and R₆ represents a C₁ -C₆ -alkyl or phenyl-C₁ -C₆ -alkyl radical, which diester is then, in accordance with the process of claim 2, reacted in the presence of a strong base with the 2-glycylamide of formula XVIII ##STR33## in which R₂ and R₃ are as defined for formula I, the resulting salt of the 2-(imidazolin-2-yl)-nicotinic acid of formula III is taken up in aqueous acidic solution, the free 2-(imidazolin-2-yl)-nicotinic acid of formula III ##STR34## in which R₂, R₃, X, Y and Z are as defined for formula I, is isolated and then rearranged with a water-removing agent or reagent to form a tricyclic 2H-imidazo-[1,2:1',2']pyrrolo[3,4-b]pyridine-3,5-dione compound of formula II ##STR35## in which R₂, R₃,, X, Y and Z are as defined for formula I, and this compound is then cleaved at elevated temperature with a hydroxide or alcohol of formula XVI

    HOR.sub.1                                                  (XVI),

in which R₁ is as defined for formula I, to yield the 2-(imidazolin-2-yl)-nicotinic acid derivative of formula I.

If the reactions do not already proceed at room temperature then they are carried out at temperatures of from 0° C. to 200° C., that is to say if necessary the reaction mixture is heated up to boiling point or, if necessary, cooled with ice/water or ice/brine bath.

Suitable bases for these condensation and hydrolysis reactions are especially inorganic bases, such as sodium hydroxide, sodium carbonate, calcium hydroxide, calcium carbonate, potassium hydroxide, potassium carbonate, ammonia and also tertiary organic bases, such as triethylamine.

Suitable solvents are, for example, polar aprotic solvents, which can be used on their own or in mixtures consisting of at least two solvents. Examples are as follows: ether, such as dibutyl ether, tetrahydrofuran, dioxan, methylene glycol, dimethyl ethylene glycol, diethyl diethylene glycol, dimethyl triethylene glycol, halogenated hydrocarbons, such as methylene chloride, chloroform, 1,2-dichloroethane, 1,1,1-trichloroethane, 1,1,2,2-tetrachloroethane, carboxylic acid esters and lactones, such as ethyl acetate, methyl propionate, ethyl benzoate, 2-methoxyethyl acetate, γ-butyrolactone, o-valerolactone and pivalolactone, carboxylic acid amides and lactams, such as formamide, acetamide, N-methylformamide, N,N-dimethylformamide, N,N-diethylformamide, N,N-dimethylacetamide, N,N-diethylacetamide, γ-butyrolactam, ε-caprolactam, N-methylpyrrolidone, N-acetylpyrrolidone, N-methylcaprolactam, tetramethylurea, hexamethylphosphoric acid triamide, sulphoxides, such as dimethyl sulphoxide, sulphones, such as dimethyl sulphone, diethyl sulphone, trimethylene sulphone, tetramethylene sulphone, trimethylamine, triethylamine, N-methylpyrrolidine, N-methylpiperidine, N-methylmorpholine, substituted benzenes, such as chlorobenzene, nitrobenzene, and nitriles, such as, for example, acetonitrile.

Preferred as herbicides or for regulating plant growth are those derivatives of 2-(imidazolin-2-yl)-nicotinic acids and derivatives of formulae III and I and also 2H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5-dione compounds of formulae II and XII, in which Z represents a C₃ -C₆ cycloalkyl, C₂ -C₈ -alkoxyalkyl, phenoxyalkyl, furanyl, dioxanyl or carbamoyloxymethoxymethyl radical.

The invention also relates to all diastereoisomeric and enantiomeric isomers of compounds of formula I.

The active ingredients of formula I are normally used successfully at application rates of from 0.05 to 4 kg/ha, especially from 0.1 to 1 kg/ha.

At lower rates of application the compounds of formula I are distinguished by good selective growth-inhibiting and selective herbicidal properties and are excellent for use in crops of useful plants, especially cereals, cotton, soybeans, maize and rice. There is also to some extent damage to weeds, hitherto to be approached only with total herbicides.

The nature of the action of these active ingredients is unusual. Many are translocatable, that is to say they are absorbed by the plant and transported to other parts of the plant where they are then active. For example, by surface-treating perennial weeds it is possible for damage to be caused right into the roots. In comparison with other herbicides and growth regulators the novel compounds of formula I are effective at very low rates of application.

The compounds of formula I in addition have pronounced plant growth-inhibiting properties. The growth of both monocotyledons and dicotyledons is impaired.

For example, leguminosae frequently planted in agriculture as cover crops in tropical areas can be selectively inhibited in their growth by the compounds of formula I, so that whilst soil erosion between the cultivated plants is prevented, the cover crops are not able to compete with the crop.

Inhibition of the vegetative growth enables denser planting of the crop in many cases, so that an increase in yield in relation to the soil area can be achieved.

Another mechanism of the yield increase using growth inhibitors is based on the fact that the nutrients are utilized to a greater extent in the flower and fruit formation whilst the vegetative growth is restricted.

At greater rates of application all plants tested are damaged in their development to such an extent that they die.

The invention relates also to herbicidal and plant growth-regulating compositions that contain a novel active ingredient of formula I, and to methods of controlling weeds pre- and post-emergence and of inhibiting the growth of monocotyledonous and dicotyledonous plants, especially grasses, tropical cover crops and tobacco suckers.

The compounds of formula I are used in unmodified form or, preferably, as compositions together with adjuvants customary in the art of formulation, and are therefore formulated in known manner, for example, into emulsifiable concentrates, directly sprayable or dilutable solutions, dilute emulsions, wettable powders, soluble powders, dusts, granulates, and encapsulations in, for example, polymeric substances. As with the nature of the compositions, the methods of application, such as spraying, atomising, dusting, scattering or pouring, are chosen in accordance with the intended objectives and the prevailing circumstances.

The formulations, that is to say the compositions, preparations or mixtures containing the active ingredient of formula I and, where appropriate, a solid or liquid adjuvant, are prepared in known manner, for example by homogeneous mixing and/or grinding of active ingredients with extenders, such as, for example, solvents, solid carriers and, where appropriate, surface-active substances (surfactants).

Suitable solvents are: aromatic hydrocarbons, preferably the fractions C₈ -C₁₂, such as, for example, xylene mixtures or substituted naphthalenes, phthalic acid esters, such as dibutyl or dioctyl phthalate, aliphatic hydrocarbons, such as cyclohexane or paraffins, alcohols and glycols and ethers and esters thereof, such as ethanol, ethylene glycol, ethylene glycol monomethyl or monoethyl ether, ketones, such as cyclohexanone, strongly polar solvents, such as N-methyl-2-pyrrolidone, dimethyl sulphoxide or dimethylformamide, and also vegetable oils or epoxidised vegetable oils, such as epoxidised coconut oil or soybean oil; or water.

The solid carriers used, for example for dusts and dispersible powders, are normally powdered natural minerals, such as calcite, talcum, kaolin, montmorillonite or attapulgite. In order to improve the physical properties it is also possible to add highly dispersed silicic acid or highly dispersed absorbent polymers. Suitable granulated adsorptive carriers are porous types, such as, for example, pumice, broken brick, sepiolite or bentonite, and suitable non-sorbent carrier materials are, for example, calcite or sand. Furthermore, a large number of pre-granulated materials of inorganic or organic nature can be used such as, especially, dolomite or pulverised plant residues.

Depending upon the nature of the active ingredient of formula I to be formulated, suitable surface-active substances are non-ionic, cationic and/or anionic surfactants having good emulsifying, dispersing and wetting properties. The term surfactants is also to include mixtures of surfactants.

Both so-called water-soluble soaps and also water-soluble synthetic surface-active compounds are suitable anionic surfactants.

As soaps there may be mentioned alkali metal, alkaline earth metal or substituted or unsubstituted ammonium salts of higher fatty acids (C₁₀ -C₂₂) such as, for example, the sodium or potassium salts of oleic or stearic acid, or of mixtures of natural fatty acids that can be obtained, for example, from coconut oil or tallow oil. Fatty acid methyltaurin salts should also be mentioned.

More frequently, however, so-called synthetic surfactants are used, especially fatty sulphonates, fatty sulphates, sulphonated benzimidazole derivatives or alkylarylsulphonates.

The fatty sulphonates or sulphates are generally in the form of alkali metal, alkaline earth metal or substituted or unsubstituted ammonium salts and contain an alkyl radical having from 8 to 22 carbon atoms, which also includes the alkyl moiety of acyl radicals, for example the sodium or calcium salt of lignosulphonic acid, of dodecylsulphuric acid ester or of a mixture of fatty alcohol sulphates produced from natural fatty acids. Also included are the salts of sulphated and sulphonated fatty alcohol/ethylene oxide adducts. The sulphonated benzimidazole derivatives preferably contain 2 sulphonic acid groups and a fatty acid radical having from 8 to 22 carbon atoms. Examples of alkylarylsulphonates are the sodium, calcium or triethanolamine salts of dodecylbenzenesulphonic acid, of dibutylnaphthalenesulphonic acid or of a naphthalenesulphonic acid/formaldehyde condensation product.

There also come into consideration corresponding phosphates such as, for example, salts of the phosphoric acid ester of an adduct of p-nonylphenol with from 4 to 14 mols of ethylene oxide, or phospholipids.

Non-ionic surfactants are especially polyglycol ether derivatives of aliphatic or cycloaliphatic alcohols, of saturated or unsaturated fatty acids and alkylphenols, which derivatives may contain from 3 to 10 glycol ether groups and from 8 to 20 carbon atoms in the (aliphatic) hydrocarbon moiety and from 6 to 18 carbon atoms in the alkyl moiety of the alkylphenols.

Further suitable non-ionic surfactants are the water-soluble adducts of polyethylene oxide with polypropylene glycol, ethylenediaminopolypropylene glycol and alkylpolypropylene glycol containing from 1 to 10 carbon atoms in the alkyl chain, which adducts contain from 20 to 250 ethylene glycol ether groups and from 10 to 100 propylene glycol ether groups. The compounds mentioned usually contain from 1 to 5 ethylene glycol units per propylene glycol unit.

There may be mentioned as examples of non-ionic surfactants nonylphenolpolyethoxyethanols, castor oil polyglycol ethers, polypropylene/polyethylene oxide adducts, tributylphenoxypolyethanol, polyethylene glycol and octylphenoxypolyethoxyethanol.

Fatty acid esters of polyoxyethylene sorbitan, such as polyoxyethylene sorbitan trioleate, also come into consideration.

The cationic surfactants are especially quaternary ammonium salts that contain, as N-substituent, at least one alkyl radical having from 8 to 22 carbon atoms and, as further substituents, lower, optionally halogenated alkyl, benzyl or lower hydroxyalkyl radicals. The salts are preferably in the form of halides, methyl sulphates or ethyl sulphates, for example stearyltrimethylammonium chloride or benzyldi-(2-chloroethyl)-ethylammonium bromide.

The surfactants customary in the art of formulation are described, inter alia, in the following publications:

"McCutcheon's Detergents and Emulsifiers Annual" MC Publishing Corp., Ridgewood, N.J., 1979.

Dr. Helmut Stache "Tensid Taschenbuch"

Carl Hanser Verlag, Munich/Vienna 1981.

The herbicidal and plant growth-regulating preparations usually contain from 0.1 to 95%, especially from 0.1 to 80%, of active ingredient of formula I, from 1 to 99.9% of a solid or liquid adjuvant and from 0 to 25%, especially from 0.1 to 25%, of a surfactant.

Preferred formulations are especially of the following composition: (%=percent by weight)

    ______________________________________                                         Emulsifiable concentrates:                                                     active ingredient                                                                             1 to 20%,  preferably 5 to 10%                                  of formula I:                                                                  surface-active agent:                                                                         5 to 30%,  preferably 10 to 20%                                 liquid carrier:                                                                               50 to 94%, preferably 70 to 85%.                                Dusts:                                                                         active ingredient                                                                             0.1 to 10%,                                                                               preferably 0.1 to 1%                                 of formula I                                                                   solid carrier: 99.9 to 90%,                                                                              preferably 99.9 to 99%                               Suspension concentrates:                                                       active ingredient                                                                             5 to 75%,  preferably 10 to 50%                                 of formula I:                                                                  water          94 to 25%, preferably 90 to 30%                                 surface-active 1 to 40%,  preferably 2 to 30%.                                 agent                                                                          Wettable powders:                                                              active ingredient                                                                             0.5 to 90%,                                                                               preferably 1 to 80%                                  of formula I:                                                                  surface active 0.5 to 20%,                                                                               preferably 1 to 15%                                  agent:                                                                         solid carrier: 5 to 95%,  preferably 15 to 90%.                                Granulates:                                                                    active ingredient                                                                             0.5 to 30%,                                                                               preferably 3 to 15%                                  of formula I:                                                                  solid carrier: 99.5 to 70%,                                                                              preferably 97 to 85%.                                ______________________________________                                    

Whilst concentrated formulations are preferred as commercial products, the end user will normally use dilute formulations. The forms of application can be diluted down to 0.001% active ingredient. The rates of application are normally from 0.005 to 5 kg of active ingredient/hectare.

The compositions may also contain other adjuvants, such as stabilisers, antifoams, viscosity regulators, binders, tackifiers and also fertilizers or other active substances for achieving special effects.

EXAMPLE 1 Preparation of 6-cyclopropyl-pyridine-2,3-dicarboxylic acid diethyl ester ##STR36##

40 g of pyridine-2,3-dicarboxylic acid diethyl ester are dissolved in a mixture of 400 g of water and 36 g of concentrated sulphuric acid and 6.1 g of silver nitrate (AgNO₃). Subsequently, 32 g of cyclopropanecarboxylic acid are added and the reaction mixture is heated to 70°. A solution of 82.1 g of ammonium peroxydisulphate (NH₄)₂ S₂ O₈ in 300 ml of water is added dropwise thereto while stirring vigorously. When the evolution of CO₂ has ceased, the reaction mixture is stirred for a further 20 minutes. It is then cooled to 15° and extracted twice with 200 ml of methylene chloride each time. The organic phase is collected, dried over magnesium sulphate, filtered and concentrated by evaporation. The residue is distilled at 13 millibars and the distillate is chromatographed over a column of silica gel with hexane/methylene chloride/ether. After the solvent has been evaporated 11.2 g of the above diester remain behind in the form of a colourless oil.

EXAMPLE 2 Preparation of 6-methoxymethylpyridine-2,3dicarboxylic acid diethyl ester ##STR37##

First of all 40 g of pyridine-2,3-dicarboxylic acid diethyl ester and then 33.3 g of methoxyacetic acid are added to a solution of 400 g of water, 36 g of concentrated sulphuric acid and 6.1 g of silver nitrate. The reaction mixture is then heated to 70° and a solution of 60.7 g of ammonium peroxydisulphate (NH₄)₂ S₂ O₈ in 225 ml of water is added dropwise thereto while stirring vigorously. When the evolution of CO₂ has ceased, the reaction mixture is stirred for a further 20 minutes. It is then cooled to 15° and extracted twice with 200 ml of methylene chloride each time. The organic phases are collected, dried over magnesium sulphate, filtered and concentrated by evaporation. The oil that remains is chromatographed over a column of silica gel with ether/hexane 1:1, there being eluted from different fractions 9.1 g of 6-methoxymethylpyridine-2,3-dicarboxylic acid in the form of crystals having a melting point of 52°-54°, 12.9 g of 4,6-bis-methoxymethylpyridine-2,3-dicarboxylic acid diethyl ester in the form of an oil and 10.2 g of 4-methoxymethylpyridine-2,3-dicarboxylic acid diethyl ester also in the form of an oil.

EXAMPLE 3 Preparation of 5-ethyl-6-methoxymethyl-pyridine-2,3-dicarboxylic acid diethyl ester ##STR38##

First of all 25.1 g of 5-ethylpyridine-2,3-dicarboxylic acid diethyl ester and then 13.5 g of methoxyacetic acid are added to a solution of 20 g of concentrated sulphuric acid and 3.4 g of silver nitrate (AgNO₃) in 200 ml of water. The reaction mixture is then heated to 70° and a solution of 34.2 g of ammonium peroxydisulphate (NH₄)₂ S₂ O₈ is added dropwise thereto while stirring vigorously. When the evolution of CO₂ has ceased, the reaction mixture is stirred for a further 20 minutes, then cooled to 15° and extracted twice with 200 ml of methylene chloride each time. The methylene chloride extracts are dried over magnesium sulphate, filtered and concentrated by evaporation. The oil that remains is purified by chromatography over a column of silica gel using ether/hexane 1:1. There are obtained from the eluate, in different fractions, 7.2 g of 5-ethyl-6-methoxymethylpyridine-2,3-dicarboxylic acid diethyl ester in the form of a light-yellow oil, 5.3 g of 4,6-bis-methoxymethyl-5-ethylpyridine-2,3-dicarboxylic acid diethyl ester in the form of a light-coloured oil and also 1 g of 5-ethyl-4-methoxymethylpyridine-2,3-dicarboxylic acid diethyl ester, also in the form of an oil.

EXAMPLE 4 Preparation of 5-ethyl-6-cyclopropyl-pyridine-2,3-dicarboxylic acid diethyl ester ##STR39##

There is added to a solution of 32 ml of concentrated sulphuric acid and 6.8 g of silver nitrate (AgNO₃) in 400 ml of water first of all 50 g of 5-ethylpyridine-2,3-dicarboxylic acid diethyl ester and, when a homogeneous solution has been obtained, 25.8 g of cyclopropanecarboxylic acid. The solution is then heated to 70° and a solution of 68.2 g of ammonium peroxydisulphate (NH₄)₂ S₂ O₈ is added dropwise thereto while stirring vigorously. When the evolution of CO₂ has ceased, the reaction mixture is stirred for a further 20 minutes, then cooled to 15° and extracted twice with 200 ml of methylene chloride each time. The methylene chloride extract is dried over magnesium sulphate, filtered and concentrated. The oily residue is purified by chromatography over a column of silica gel using ether/hexane 1:1. Evaporation of the solvent yields 20 g of 5-ethyl-6-cyclopropyl-pyridine-2,3-dicarboxylic acid in the form of a yellow oil.

The following diesters of formula IV are prepared in a manner analogous to that described in Examples 1 to 4: ##STR40##

                                      TABLE 1.00                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                             R.sub.4                                                                             Z      phys. data                                    __________________________________________________________________________     1.0001                                                                             H H         C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                                                               m.p.155-163/0.13 mbar                         1.0002                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                                                               oil                                           1.0003                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                                                               oil                                           1.0004                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0005                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0006                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0007                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0008                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0009                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0010                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0011                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0012                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0013                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0014                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0015                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0016                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0017                                                                             H Br        C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                                                               oil                                           1.0018                                                                             H Cl        C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0019                                                                             H F         C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0020                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0021                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0022                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0023                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0024                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0025                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0026                                                                             H CN        C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0027                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0028                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0029                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0030                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0031                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0032                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0033                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              1.0034                                                                             H H         C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.7 -iso                                                                C.sub.3 H.sub.5 (cyclo)                              1.0035                                                                             H H         C.sub.3 H.sub.7                                                                     CH.sub.2 C.sub.6 H.sub.5                                                            C.sub.3 H.sub.5 (cyclo)                              1.0036                                                                             H H         CH.sub.3                                                                            CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                              1.0037                                                                             H H         CH.sub.2 C.sub.6 H.sub.5                                                            CH.sub.2 C.sub.6 H.sub.5                                                            C.sub.2 H.sub.5 (cyclo)                              __________________________________________________________________________

                                      TABLE 1.01                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z       phys. data                                       __________________________________________________________________________     1.0101                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0102                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0103                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0104                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0105                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0106                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0107                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0108                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0109                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0110                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0111                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0112                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0113                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0114                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0115                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0116                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0117                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0118                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0119                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0120                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0121                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                  C.sub.4 H.sub.7 (cyclo)                                  1.0122                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0123                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0124                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0125                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0126                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0127                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0128                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0129                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0130                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0131                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0132                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  1.0133                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.4 H.sub.7 (cyclo)                                  __________________________________________________________________________

                                      TABLE 1.02                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z       phys. data                                       __________________________________________________________________________     1.0201                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0202                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0203                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0204                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0205                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0206                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0207                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0208                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0209                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0210                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0211                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0212                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0213                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0214                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0215                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0216                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0217                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0218                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0219                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0220                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0221                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                  C.sub.5 H.sub.9 (cyclo)                                  1.0222                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0223                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0224                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0225                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0226                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0227                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0228                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0229                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0230                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0231                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0232                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  1.0233                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.5 H.sub.9 (cyclo)                                  __________________________________________________________________________

                                      TABLE 1.03                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z       phys. data                                       __________________________________________________________________________     1.0301                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                                               oil                                              1.0302                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0303                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0304                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0305                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0306                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0307                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0308                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0309                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0310                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0311                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0312                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0313                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0314                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0315                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0316                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0317                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0318                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0319                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0320                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0321                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                  C.sub.6 H.sub.11 (cyclo)                                 1.0322                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0323                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0324                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0325                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0326                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0327                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0328                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0329                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0330                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0331                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0332                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 1.0333                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C.sub.6 H.sub.11 (cyclo)                                 __________________________________________________________________________

                                      TABLE 1.04                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z     phys. data                                         __________________________________________________________________________     1.0401                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                                                   m.p. 52-54° C.                              1.0402                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                                                   oil                                                1.0403                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                                                   oil                                                1.0404                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0405                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0406                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0407                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0408                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0409                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0410                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub. 2 H.sub.5                                                                  C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0411                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0412                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0413                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0414                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0415                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0416                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0417                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0418                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0419                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0420                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0421                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0422                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0423                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0424                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0425                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0426                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0427                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0428                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0429                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0430                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0431                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0432                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       1.0433                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub. 2 H.sub.5                                                                  C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.3                                       __________________________________________________________________________

                                      TABLE 1.05                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z       phys. data                                       __________________________________________________________________________     1.0501                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0502                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0503                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0504                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0505                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0506                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0507                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0508                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0509                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0510                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                  CH(CH.sub.3)OCH.sub.3                                    1.0511                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0512                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0513                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0514                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0515                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0516                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0517                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0518                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0519                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0520                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0521                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0522                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0523                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0524                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0525                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0526                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0527                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0528                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0529                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0530                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0531                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0532                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OCH.sub.3                                    1.0533                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                  CH(CH.sub.3)OCH.sub.3                                    __________________________________________________________________________

                                      TABLE 1.06                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z     phys. data                                         __________________________________________________________________________     1.0601                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                                            b.p.140-145°/0.13 mbar                      1.0602                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                                            oil                                                1.0603                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                                            oil                                                1.0604                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0605                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0606                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0607                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0608                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0609                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0610                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0611                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0612                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0613                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0614                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0615                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0616                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0617                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0618                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0619                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0620                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0621                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0622                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0623                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0624                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0625                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0626                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0627                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0628                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0629                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0630                                                                             H C.sub.6 H.sub.5                                                                          C.sub. 2 H.sub.5                                                                  C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0631                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0632                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                1.0633                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.5                                __________________________________________________________________________

                                      TABLE 1.07                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z        phys. data                                      __________________________________________________________________________     1.0701                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0702                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0703                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0704                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0705                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0706                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0707                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0708                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0709                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub. 3)OC.sub.2 H.sub.5                            1.0710                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0711                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0712                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0713                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0714                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0715                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0716                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0717                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0718                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0719                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0720                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                  CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0721                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0722                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0723                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0724                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0725                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0726                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0727                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0728                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0729                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0730                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0731                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0732                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             1.0733                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH(CH.sub.3)OC.sub.2 H.sub.5                             __________________________________________________________________________

                                      TABLE 1.08                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z       phys. data                                       __________________________________________________________________________     1.0801                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                                                            oil                                              1.0802                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0803                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0804                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0805                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0806                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0807                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0808                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0809                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub. 3).sub.2 OCH.sub.3                             1.0810                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0811                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0812                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0813                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0814                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0815                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0816                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0817                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0818                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0819                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0820                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                  C(CH.sub.3).sub.2 OCH.sub.3                              1.0821                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0822                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0823                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0824                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0825                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0826                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0827                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0828                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0829                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0830                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0831                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0832                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              1.0833                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3).sub.2 OCH.sub.3                              __________________________________________________________________________

                                      TABLE 1.09                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                            Z      phys. data                                       __________________________________________________________________________     1.0901                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0902                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0903                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0904                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0905                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0906                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0907                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0908                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0909                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub. 2 OC.sub.3 H.sub.7                              1.0910                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0911                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0912                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0913                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0914                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0915                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0916                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0917                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0918                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0919                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0920                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                   CH.sub.2 OC.sub.3 H.sub.7                               1.0921                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0922                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0923                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0924                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0925                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0926                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0927                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0928                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0929                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0930                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0931                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0932                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               1.0933                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    CH.sub.2 OC.sub.3 H.sub.7                               __________________________________________________________________________

                                      TABLE 1.10                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z         phys. data                                     __________________________________________________________________________     1.1001                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                                                       oil                                            1.1002                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1003                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1004                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1005                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1006                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1007                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1008                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1009                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub. 2 H.sub.5                                                                  C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1010                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1011                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1012                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1013                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1014                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1015                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1016                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1017                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1018                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1019                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                  C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1020                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1021                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1022                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1023                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1024                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1025                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1026                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1027                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1028                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1029                                                                             H CH.sub.2 CH.sub.2 CH.sub. 2 OH                                                           C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1030                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1031                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1032                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       1.1033                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                       __________________________________________________________________________

                                      TABLE 1.11                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z     phys. data                                         __________________________________________________________________________     1.1101                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                                            m.p. 78-79° C.                              1.1102                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1103                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1104                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1105                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1106                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1107                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1108                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1109                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub. 2 H.sub.5                                                                  CH.sub.2 OC.sub.6 H.sub.5                                1.1110                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1111                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1112                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1113                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1114                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1115                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1116                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1117                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1118                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1119                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1120                                                                             H SCH.sub.3 C.sub.2 H.sub. 5                                                                  C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1121                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1122                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1123                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1124                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1125                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1126                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1127                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1128                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1129                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1130                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1131                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1132                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                1.1133                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.6 H.sub.5                                __________________________________________________________________________

                                      TABLE 1.12                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                            Z      phys. data                                       __________________________________________________________________________     1.1201                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                                                            oil                                              1.1202                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1203                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1204                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1205                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1206                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1207                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1208                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1209                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1210                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1211                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1212                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1213                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1214                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1215                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1216                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1217                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1218                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1219                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1220                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1221                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1222                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1223                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1224                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1225                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1226                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1227                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1228                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1229                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1230                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1231                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1232                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              1.1233                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    furan-2-yl                                              __________________________________________________________________________

                                      TABLE 1.13                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                            Z      phys. data                                       __________________________________________________________________________     1.1301                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                                                           oil                                              1.1302                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1303                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1304                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1305                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1306                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1307                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1308                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1309                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1310                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1311                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1312                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1313                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1314                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1315                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1316                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1317                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1318                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1319                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1320                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1321                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1322                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1323                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1324                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1325                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1326                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1327                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1328                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1329                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1330                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1331                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1332                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             1.1333                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                    dioxan-2-yl                                             __________________________________________________________________________

                                      TABLE 1.14                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z        phys. data                                      __________________________________________________________________________     1.1401                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                                                     oil                                             1.1402                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1403                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1404                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1405                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1406                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1407                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1408                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1409                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1410                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1411                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1412                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1413                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1414                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1415                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1416                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1417                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1418                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub. 5                                                                  CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1419                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1420                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1421                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1422                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1423                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1424                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1425                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1426                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1427                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1428                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1429                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1430                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1431                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1432                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      1.1433                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                      __________________________________________________________________________

                                      TABLE 1.15                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z           phys. data                                   __________________________________________________________________________     1.1501                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3                           2           oil                                          1.1502                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3                           1                                                        1.1503                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3                           1                                                        1.1504                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3                           .                                                        1.1505                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1506                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1507                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub. 2 H.sub.4                                    OCH.sub.3                                                1.1508                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1509                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1510                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1511                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1512                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1513                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1514                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1515                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub. 2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                    OCH.sub.3                                                1.1516                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1517                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1518                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1519                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1520                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1521                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1522                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1523                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub. 4 OC.sub.2 H.sub.4                                    OCH.sub.3                                                1.1524                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1525                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1526                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1527                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1528                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1529                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1530                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1531                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1532                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     1.1533                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3     __________________________________________________________________________

                                      TABLE 1.16                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           R.sub.4                                                                           Z         phys. data                                     __________________________________________________________________________     1.1601                                                                             H H         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                                                            oil                                            1.1602                                                                             H CH.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1603                                                                             H C.sub.2 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1604                                                                             H C.sub.3 H.sub.7                                                                          C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1605                                                                             H OCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1606                                                                             H OC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1607                                                                             H OCH.sub.2 CH═CH.sub.2                                                                C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1608                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1609                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub. 2 OCH.sub.2 CONH.sub.2                           1.1610                                                                             H OCH.sub.2 CH═CHCl                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1611                                                                             H OCH.sub.2 C.tbd.CH                                                                       C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1612                                                                             H OCHF.sub.2                                                                               C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1613                                                                             H OCF.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1614                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1615                                                                             H OC.sub.6 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1616                                                                             H CF.sub.3  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1617                                                                             H Br        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1618                                                                             H Cl        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1619                                                                             H F         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1620                                                                             H SCH.sub.3 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1621                                                                             H SC.sub.2 H.sub.5                                                                         C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1622                                                                             H SC.sub.3 H.sub.7 -n                                                                      C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1623                                                                             H SO.sub.2 CH.sub.3                                                                        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1624                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1625                                                                             H NO.sub.2  C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1626                                                                             H CN        C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1627                                                                             H CH.sub.2 OH                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1628                                                                             H CH.sub.2 CH.sub.2 OH                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1629                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1630                                                                             H C.sub.6 H.sub.5                                                                          C.sub.2 H.sub.5                                                                   C.sub. 2 H.sub.5                                                                  CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1631                                                                             H CH.sub.2 Cl                                                                              C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1632                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            1.1633                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                            __________________________________________________________________________

EXAMPLE 5 Preparation of 6-cyclopropyl-2-(5-isopropyl-5-methyl-4-oxoimidazolin-2-yl)-pyridine-3-carboxylic acid ##STR41##

10 g of 30% sodium methoxide in methanol are added to a solution of 6 g of 6-cyclopropylpyridine-2,3-dicarboxylic acid diethyl ester and 3 g of 2-amino-2,3-dimethylbutyramide in 100 ml of ethanol and the reaction mixture is boiled under reflux for 3 hours. It is then concentrated, the residue is dissolved in a small amount of water, and the solution is saturated with sodium chloride. The pH is then adjusted to 4 with concentrated hydrochloric acid and the solution is extracted three times with 150 ml of ethyl acetate each time. The organic phase is dried over magnesium sulphate, filtered and concentrated. The residue crystallises from ether/hexane 1:2. In this manner 4 g of 6-cyclopropyl-2-(5-isopropyl-5-methyl-4-oxoimidazolin-2-yl)-pyridinecarboxylic acid having a melting point of 118°-121° are obtained.

EXAMPLE 6 Preparation of 6-methoxy-5-methyl-2-(5-isopropyl-5-methyl-4-oxoimidazolin-2-yl)-pyridine-3-carboxylic acid ##STR42##

5 g of potassium tert.-butoxide are added in portions at a temperature of 80° C. to a solution of 5.7 g of 6-methoxymethyl-5-methylpyridine-2,3-dicarboxylic acid diethyl ester and 2.6 g of 2-amino-2,3-dimethylbutyramide in 200 ml of dry toluene while stirring. Once the addition of the potassium tert.-butoxide is complete, the resulting red solution is stirred for 2 hours at 80° C., the potassium salt of 2-(5-isopropyl-5-methyl-4-oxoimidazolin-2-yl)-5-ethylpyridine-3-carboxylic acid being deposited in the form of a thick crystalline slurry. The mixture is cooled to room temperature and filtered with suction, and the crystals are dried and then dissolved in 50 ml of saturated sodium chloride solution. The solution is adjusted to pH 4 with concentrated hydrochloric acid and then extracted three times with 100 ml of ethyl acetate each time. The organic phase is dried over magnesium sulphate, filtered off with suction and concentrated by evaporation. The residue crystallises from ether/hexane 1:2 yielding 2.8 g of the above acid, which has a melting point of 151°-153° C.

EXAMPLE 7 Preparation of 5-ethyl-6-methoxymethyl-2-(5-isopropyl-5-methyl-4-oxo-imidazol-2H-1-yl)-pyridine-3-carboxylic acid ##STR43##

17.4 g of potassium tert.-butoxide are added to a solution of 18.3 g of 5-ethyl-6-methoxymethylpyridine-2,3-dicarboxylic acid in 300 ml of dry toluene at a temperature of 80° C. The resulting solution is then stirred for 3 hours at 80° C. and finally cooled to 15° C. The resulting crystallisate is filtered off with suction, dried and taken up in a small amount of saturated sodium chloride solution. The sodium chloride solution is adjusted to pH 4 with concentrated hydrochloric acid and then extracted three times with 150 ml of ethyl acetate each time. The organic phase is dried over magnesium sulphate, filtered off with suction and concentrated by evaporation. The residue crystallises from ether/hexane 1:2. In this manner 11.9 g of the above acid having a melting point of 134°-137° C. are obtained.

EXAMPLE 8 Preparation of 6-(thiophen-3-yl)-2-(5-isopropyl-5-methyl-4-oxo-imidazol-2-yl)-pyridine-3-carboxylic acid ##STR44##

12 g of potassium tert.-butoxide are added to a solution of 14 g of 6-(thiophen-3-yl)-pyridine-2,3-dicarboxylic acid diethyl ester and 6 g of 2-amino-2,3-dimethyl- butyramide in 100 ml of dry toluene while stirring and the solution is heated at 80° C. for 5 hours. The reaction solution is then poured onto ice, the phases are separated and the aqueous phase is acidified with 10 ml of glacial acetic acid. After some time the above acid crystallises out and is filtered off with suction and dried. In this manner 13.5 g of 6-(thiophen-3-yl)-2-(5-isopropyl-5-methyl-4-oxo-imidazol-2-yl)-pyridine-3-carboxylic acid having a melting point of 253°-257° C. are obtained.

The 6-(thiophen-3-yl)-pyridine-2,3-dicarboxylic acid diethyl ester required as starting material is prepared as follows:

(a) 1-morpholino-1-(thiophen-3-yl)-ethylene

A solution of 57 g of titanium tetrachloride (TiCl₄) in 100 ml of cyclohexane is added dropwise to a stirred solution of 75 g of 3-acetylthiophene and 160 g of morpholine in a liter of cyclohexane. When the addition is complete, the reaction mixture is further stirred at room temperature for 12 hours, then the precipitate is filtered off and the filtrate is concentrated by evaporation. The residue is distilled and has a boiling point of 98°/0.04 millibar. In this manner 36.5 g of 1-morpholino-1-(thiophen-3-yl)-ethylene are obtained in the form of a colourless oil.

(b) A solution of 25 g of this ethylene in 50 ml of ethanol is stirred with 31 g of ethoxymethyleneoxalacetic acid ester (C₂ H₅ OCH═C(COOC₂ H₅)COCOOC₂ H₅).

After 2 hours 27.5 g of a 9.3% solution of ammonia in absolute alcohol are added thereto and the reaction mixture is stirred for a further hour at room temperature. Crystals separate out from the solution on standing overnight. They are filtered off and recrystallised from toluene/hexane. In this manner 22.5 g of 6-(thiophen-3-yl)-pyridine-2,3dicarboxylic acid diethyl ester having a melting point of 100°-101.5° C. are obtained.

The 2-(5-isopropyl-5-methyl-4-oxo-imidazol-2-yl)-pyridine-3-carboxylic acids (nicotinic acids) of formula III listed in Tables 2.00 to 2.26 are prepared analogously to Examples 5 to 8. ##STR45##

                  TABLE 2.00                                                       ______________________________________                                         No.   X     Y             Z        phys. data                                  ______________________________________                                         2.0001                                                                               H     H             C.sub.3 H.sub.5 (cyclo)                                                                 m.p.                                                                           118-121° C.                          2.0002                                                                               H     CH.sub.3      C.sub.3 H.sub.5 (cyclo)                                                                 m.p.                                                                           206-208° C.                          2.0003                                                                               H     C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.5 (cyclo)                                                                 m.p.                                                                           169-172° C.                          2.0004                                                                               H     C.sub.3 H.sub.7                                                                              C.sub.3 H.sub.5 (cyclo)                              2.0005                                                                               H     OCH.sub.3     C.sub.3 H.sub.5 (cyclo)                              2.0006                                                                               H     OC.sub.2 H.sub.5                                                                             C.sub.3 H.sub.5 (cyclo)                              2.0007                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    C.sub.3 H.sub.5 (cyclo)                              2.0008                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  C.sub.3 H.sub.5 (cyclo)                              2.0009                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 C.sub.3 H.sub.5 (cyclo)                              2.0010                                                                               H     OCH.sub.2 CH═CHCl                                                                        C.sub.3 H.sub.5 (cyclo)                              2.0011                                                                               H     OCH.sub.2 C.tbd.CH                                                                           C.sub.3 H.sub.5 (cyclo)                              2.0012                                                                               H     OCHF.sub.2    C.sub.3 H.sub.5 (cyclo)                              2.0013                                                                               H     OCF.sub.3     C.sub.3 H.sub.5 (cyclo)                              2.0014                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        C.sub.3 H.sub.5 (cyclo)                              2.0015                                                                               H     OC.sub.6 H.sub.5                                                                             C.sub. 3 H.sub.5 (cyclo)                             2.0016                                                                               H     CF.sub.3      C.sub.3 H.sub.5 (cyclo)                              2.0017                                                                               H     Br            C.sub.3 H.sub.5 (cyclo)                                                                 foam                                        2.0018                                                                               H     Cl            C.sub.3 H.sub.5 (cyclo)                              2.0019                                                                               H     F             C.sub.3 H.sub.5 (cyclo)                              2.0020                                                                               H     SCH.sub.3     C.sub.3 H.sub.5 (cyclo)                              2.0021                                                                               H     SC.sub.2 H.sub.5                                                                             C.sub.3 H.sub.5 (cyclo)                              2.0022                                                                               H     SC.sub.3 H.sub.7 -n                                                                          C.sub.3 H.sub.5 (cyclo)                              2.0023                                                                               H     SO.sub.2 CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                              2.0024                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              2.0025                                                                               H     NO.sub.2      C.sub.3 H.sub.5 (cyclo)                              2.0026                                                                               H     CN            C.sub.3 H.sub.5 (cyclo)                              2.0027                                                                               H     CH.sub.2 OH   C.sub.3 H.sub.5 (cyclo)                              2.0028                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         C.sub.3 H.sub.5 (cyclo)                              2.0029                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                C.sub.3 H.sub.5 (cyclo)                              2.0030                                                                               H     C.sub.6 H.sub.5                                                                              C.sub.3 H.sub.5 (cyclo)                              2.0031                                                                               H     CH.sub.2 Cl   C.sub.3 H.sub.5 (cyclo)                              2.0032                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         C.sub.3 H.sub.5 (cyclo)                              2.0033                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                C.sub.3 H.sub.5 (cyclo)                              ______________________________________                                    

                  TABLE 2.01                                                       ______________________________________                                         No.   X     Y             Z        phys. data                                  ______________________________________                                         2.0101                                                                               H     H             C.sub.4 H.sub.7 (cyclo)                              2.0102                                                                               H     CH.sub.3      C.sub.4 H.sub.7 (cyclo)                              2.0103                                                                               H     C.sub.2 H.sub.5                                                                              C.sub.4 H.sub.7 (cyclo)                              2.0104                                                                               H     C.sub.3 H.sub.7                                                                              C.sub.4 H.sub.7 (cyclo)                              2.0105                                                                               H     OCH.sub.3     C.sub.4 H.sub.7 (cyclo)                              2.0106                                                                               H     OC.sub.2 H.sub.5                                                                             C.sub.4 H.sub.7 (cyclo)                              2.0107                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    C.sub.4 H.sub.7 (cyclo)                              2.0108                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  C.sub.4 H.sub.7 (cyclo)                              2.0109                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 C.sub.4 H.sub.7 (cyclo)                              2.0110                                                                               H     OCH.sub.2 CH═CHCl                                                                        C.sub.4 H.sub.7 (cyclo)                              2.0111                                                                               H     OCH.sub.2 C.tbd.CH                                                                           C.sub.4 H.sub.7 (cyclo)                              2.0112                                                                               H     OCHF.sub.2    C.sub.4 H.sub.7 (cyclo)                              2.0113                                                                               H     OCF.sub.3     C.sub.4 H.sub.7 (cyclo)                              2.0114                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        C.sub.4 H.sub.7 (cyclo)                              2.0115                                                                               H     OC.sub.6 H.sub.5                                                                             C.sub.4 H.sub.7 (cyclo)                              2.0116                                                                               H     CF.sub.3      C.sub.4 H.sub.7 (cyclo)                              2.0117                                                                               H     Br            C.sub.4 H.sub.7 (cyclo)                              2.0118                                                                               H     Cl            C.sub.4 H.sub.7 (cyclo)                              2.0119                                                                               H     F             C.sub.4 H.sub.7 (cyclo)                              2.0120                                                                               H     SCH.sub.3     C.sub.4 H.sub.7 (cyclo)                              2.0121                                                                               H     SC.sub.2 H.sub.5                                                                             C.sub.4 H.sub.7 (cyclo)                              2.0122                                                                               H     SC.sub.3 H.sub.7 -n                                                                          C.sub.4 H.sub.7 (cyclo)                              2.0123                                                                               H     SO.sub.2 CH.sub.3                                                                            C.sub.4 H.sub.7 (cyclo)                              2.0124                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                              2.0125                                                                               H     NO.sub.2      C.sub.4 H.sub.7 (cyclo)                              2.0126                                                                               H     CN            C.sub.4 H.sub.7 (cyclo)                              2.0127                                                                               H     CH.sub.2 OH   C.sub.4 H.sub.7 (cyclo)                              2.0128                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         C.sub.4 H.sub.7 (cyclo)                              2.0129                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                C.sub.4 H.sub.7 (cyclo)                              2.0130                                                                               H     C.sub.6 H.sub.5                                                                              C.sub.4 H.sub.7 (cyclo)                              2.0131                                                                               H     CH.sub.2 Cl   C.sub.4 H.sub.7 (cyclo)                              2.0132                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         C.sub.4 H.sub.7 (cyclo)                              2.0133                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                C.sub.4 H.sub.7 (cyclo)                              ______________________________________                                    

                  TABLE 2.02                                                       ______________________________________                                         No.   X     Y             Z        phys. data                                  ______________________________________                                         2.0201                                                                               H     H             C.sub.5 H.sub.9 (cyclo)                              2.0202                                                                               H     CH.sub.3      C.sub.5 H.sub.9 (cyclo)                              2.0203                                                                               H     C.sub.2 H.sub.5                                                                              C.sub.5 H.sub.9 (cyclo)                              2.0204                                                                               H     C.sub.3 H.sub.7                                                                              C.sub.5 H.sub.9 (cyclo)                              2.0205                                                                               H     OCH.sub.3     C.sub.5 H.sub.9 (cyclo)                              2.0206                                                                               H     OC.sub.2 H.sub.5                                                                             C.sub.5 H.sub.9 (cyclo)                              2.0207                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    C.sub.5 H.sub.9 (cyclo)                              2.0208                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  C.sub.5 H.sub.9 (cyclo)                              2.0209                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 C.sub.5 H.sub.9 (cyclo)                              2.0210                                                                               H     OCH.sub.2 CH═CHCl                                                                        C.sub.5 H.sub.9 (cyclo)                              2.0211                                                                               H     OCH.sub.2 C.tbd.CH                                                                           C.sub.5 H.sub.9 (cyclo)                              2.0212                                                                               H     OCHF.sub.2    C.sub.5 H.sub.9 (cyclo)                              2.0213                                                                               H     OCF.sub.3     C.sub.5 H.sub.9 (cyclo)                              2.0214                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        C.sub.5 H.sub.9 (cyclo)                              2.0215                                                                               H     OC.sub.6 H.sub.5                                                                             C.sub.5 H.sub.9 (cyclo)                              2.0216                                                                               H     CF.sub.3      C.sub.5 H.sub.9 (cyclo)                              2.0217                                                                               H     Br            C.sub.5 H.sub.9 (cyclo)                              2.0218                                                                               H     Cl            C.sub.5 H.sub.9 (cyclo)                              2.0219                                                                               H     F             C.sub.5 H.sub.9 (cyclo)                              2.0220                                                                               H     SCH.sub.3     C.sub.5 H.sub.9 (cyclo)                              2.0221                                                                               H     SC.sub.2 H.sub.5                                                                             C.sub.5 H.sub.9 (cyclo)                              2.0222                                                                               H     SC.sub.3 H.sub.7 -n                                                                          C.sub.5 H.sub.9 (cyclo)                              2.0223                                                                               H     SO.sub.2 CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                              2.0224                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     C.sub.5 H.sub.9 (cyclo)                              2.0225                                                                               H     NO.sub.2      C.sub.5 H.sub.9 (cyclo)                              2.0226                                                                               H     CN            C.sub.5 H.sub.9 (cyclo)                              2.0227                                                                               H     CH.sub.2 OH   C.sub.5 H.sub.9 (cyclo)                              2.0228                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         C.sub.5 H.sub.9 (cyclo)                              2.0229                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                C.sub.5 H.sub.9 (cyclo)                              2.0230                                                                               H     C.sub.6 H.sub.5                                                                              C.sub.5 H.sub.9 (cyclo)                              2.0231                                                                               H     CH.sub.2 Cl   C.sub.5 H.sub.9 (cyclo)                              2.0232                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         C.sub.5 H.sub.9 (cyclo)                              2.0233                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                C.sub.5 H.sub.9 (cyclo)                              ______________________________________                                    

                  TABLE 2.03                                                       ______________________________________                                         No.   X     Y             Z        phys. data                                  ______________________________________                                         2.0301                                                                               H     H             C.sub.6 H.sub.11 (cyclo)                                                                m.p.                                                                           188-190° C.                          2.0302                                                                               H     CH.sub.3      C.sub.6 H.sub.11 (cyclo)                             2.0303                                                                               H     C.sub.2 H.sub.5                                                                              C.sub.6 H.sub.11 (cyclo)                             2.0304                                                                               H     C.sub.3 H.sub.7                                                                              C.sub.6 H.sub.11 (cyclo)                             2.0305                                                                               H     OCH.sub.3     C.sub.6 H.sub.11 (cyclo)                             2.0306                                                                               H     OC.sub.2 H.sub.5                                                                             C.sub.6 H.sub.11 (cyclo)                             2.0307                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    C.sub.6 H.sub.11 (cyclo)                             2.0308                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  C.sub.6 H.sub.11 (cyclo)                             2.0309                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 C.sub.6 H.sub.11 (cyclo)                             2.0310                                                                               H     OCH.sub.2 CH═CHCl                                                                        C.sub.6 H.sub.11 (cyclo)                             2.0311                                                                               H     OCH.sub.2 C.tbd.CH                                                                           C.sub.6 H.sub.11 (cyclo)                             2.0312                                                                               H     OCHF.sub.2    C.sub.6 H.sub.11 (cyclo)                             2.0313                                                                               H     OCF.sub.3     C.sub.6 H.sub.11 (cyclo)                             2.0314                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        C.sub.6 H.sub.11 (cyclo)                             2.0315                                                                               H     OC.sub.6 H.sub.5                                                                             C.sub.6 H.sub.11 (cyclo)                             2.0316                                                                               H     CF.sub.3      C.sub.6 H.sub.11 (cyclo)                             2.0317                                                                               H     Br            C.sub.6 H.sub.11 (cyclo)                             2.0318                                                                               H     Cl            C.sub.6 H.sub.11 (cyclo)                             2.0319                                                                               H     F             C.sub.6 H.sub.11 (cyclo)                             2.0320                                                                               H     SCH.sub.3     C.sub.6 H.sub.11 (cyclo)                             2.0321                                                                               H     SC.sub.2 H.sub.5                                                                             C.sub.6 H.sub.11 (cyclo)                             2.0322                                                                               H     SC.sub.3 H.sub.7 -n                                                                          C.sub.6 H.sub.11 (cyclo)                             2.0323                                                                               H     SO.sub.2 CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                             2.0324                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     C.sub.6 H.sub.11 (cyclo)                             2.0325                                                                               H     NO.sub.2      C.sub.6 H.sub.11 (cyclo)                             2.0326                                                                               H     CN            C.sub.6 H.sub.11 (cyclo)                             2.0327                                                                               H     CH.sub.2 OH   C.sub.6 H.sub.11 (cyclo)                             2.0328                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         C.sub.6 H.sub.11 (cyclo)                             2.0329                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                C.sub.6 H.sub.11 (cyclo)                             2.0330                                                                               H     C.sub.6 H.sub.5                                                                              C.sub.6 H.sub.11 (cyclo)                             2.0331                                                                               H     CH.sub.2 Cl   C.sub.6 H.sub.11 (cyclo)                             2.0332                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         C.sub.6 H.sub.11 (cyclo)                             2.0333                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                C.sub.6 H.sub.11 (cyclo)                             ______________________________________                                    

                  TABLE 2.04                                                       ______________________________________                                         No.   X      Y             Z       phys. data                                  ______________________________________                                         2.0401                                                                               H      H             CH.sub.2 OCH.sub.3                                                                     m.p.                                                                           168-169° C.                          2.0402                                                                               H      CH.sub.3      CH.sub.2 OCH.sub.3                                                                     m.p.                                                                           151-153° C.                          2.0403                                                                               H      C.sub.2 H.sub.5                                                                              CH.sub.2 OCH.sub.3                                                                     m.p.                                                                           134-137° C.                          2.0404                                                                               H      C.sub.3 H.sub.7                                                                              CH.sub.2 OCH.sub.3                                  2.0405                                                                               H      OCH.sub.3     CH.sub.2 OCH.sub.3                                  2.0406                                                                               H      OC.sub.2 H.sub.5                                                                             CH.sub.2 OCH.sub.3                                  2.0407                                                                               H      OCH.sub.2 CH═CH.sub.2                                                                    CH.sub.2 OCH.sub.3                                  2.0408                                                                               H      OCH.sub.2 CH═CHCH.sub.3                                                                  CH.sub.2 OCH.sub.3                                  2.0409                                                                               H      OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH.sub.2 OCH.sub.3                                  2.0410                                                                               H      OCH.sub.2 CH═CHCl                                                                        CH.sub.2 OCH.sub.3                                  2.0411                                                                               H      OCH.sub.2 C.tbd.CH                                                                           CH.sub.2 OCH.sub.3                                  2.0412                                                                               H      OCHF.sub.2    CH.sub.2 OCH.sub.3                                  2.0413                                                                               H      OCF.sub.3     CH.sub.2 OCH.sub.3                                  2.0414                                                                               H      OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.2 OCH.sub.3                                  2.0415                                                                               H      OC.sub.6 H.sub.5                                                                             CH.sub.2 OCH.sub.3                                  2.0416                                                                               H      CF.sub.3      CH.sub.2 OCH.sub.3                                  2.0417                                                                               H      Br            CH.sub.2 OCH.sub.3                                  2.0418                                                                               H      Cl            CH.sub.2 OCH.sub.3                                  2.0419                                                                               H      F             CH.sub.2 OCH.sub.3                                  2.0420                                                                               H      SCH.sub.3     CH.sub.2 OCH.sub.3                                  2.0421                                                                               H      SC.sub.2 H.sub.5                                                                             CH.sub.2 OCH.sub.3                                  2.0422                                                                               H      SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OCH.sub.3                                  2.0423                                                                               H      SO.sub.2 CH.sub.3                                                                            CH.sub.2 OCH.sub.3                                  2.0424                                                                               H      SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OCH.sub.3                                  2.0425                                                                               H      NO.sub.2      CH.sub.2 OCH.sub.3                                  2.0426                                                                               H      CN            CH.sub.2 OCH.sub.3                                  2.0427                                                                               H      CH.sub.2 OH   CH.sub.2 OCH.sub.3                                  2.0428                                                                               H      CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OCH.sub.3                                  2.0429                                                                               H      CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.2 OCH.sub.3                                  2.0430                                                                               H      C.sub.6 H.sub.5                                                                              CH.sub.2 OCH.sub.3                                  2.0431                                                                               H      CH.sub.2 Cl   CH.sub.2 OCH.sub.3                                  2.0432                                                                               H      CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OCH.sub.3                                  2.0433                                                                               H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OCH.sub.3                                  2.0434                                                                               CH.sub.3                                                                              CH.sub.3      CH.sub.2 OCH.sub.3                                                                     oil                                         ______________________________________                                    

                  TABLE 2.05                                                       ______________________________________                                         No.   X     Y             Z         phys. data                                 ______________________________________                                         2.0501                                                                               H     H             CH(CH.sub.3)OCH.sub.3                                2.0502                                                                               H     CH.sub.3      CH(CH.sub.3)OCH.sub.3                                2.0503                                                                               H     C.sub.2 H.sub.5                                                                              CH(CH.sub.3)OCH.sub.3                                2.0504                                                                               H     C.sub.3 H.sub.7                                                                              CH(CH.sub.3)OCH.sub.3                                2.0505                                                                               H     OCH.sub.3     CH(CH.sub.3)OCH.sub.3                                2.0506                                                                               H     OC.sub.2 H.sub.5                                                                             CH(CH.sub.3)OCH.sub.3                                2.0507                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH(CH.sub.3)OCH.sub.3                                2.0508                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH(CH.sub.3)OCH.sub.3                                2.0509                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH(CH.sub.3)OCH.sub.3                                2.0510                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH(CH.sub.3)OCH.sub.3                                2.0511                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH(CH.sub.3)OCH.sub.3                                2.0512                                                                               H     OCHF.sub.2    CH(CH.sub.3)OCH.sub.3                                2.0513                                                                               H     OCF.sub.3     CH(CH.sub.3)OCH.sub.3                                2.0514                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH(CH.sub.3)OCH.sub.3                                2.0515                                                                               H     OC.sub.6 H.sub.5                                                                             CH(CH.sub.3)OCH.sub.3                                2.0516                                                                               H     CF.sub.3      CH(CH.sub.3)OCH.sub.3                                2.0517                                                                               H     Br            CH(CH.sub.3)OCH.sub.3                                2.0518                                                                               H     Cl            CH(CH.sub.3)OCH.sub.3                                2.0519                                                                               H     F             CH(CH.sub.3)OCH.sub.3                                2.0520                                                                               H     SCH.sub.3     CH(CH.sub.3)OCH.sub.3                                2.0521                                                                               H     SC.sub.2 H.sub.5                                                                             CH(CH.sub.3)OCH.sub.3                                2.0522                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH(CH.sub.3)OCH.sub.3                                2.0523                                                                               H     SO.sub.2 CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                                2.0524                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH(CH.sub.3)OCH.sub.3                                2.0525                                                                               H     NO.sub.2      CH(CH.sub.3)OCH.sub.3                                2.0526                                                                               H     CN            CH(CH.sub.3)OCH.sub.3                                2.0527                                                                               H     CH.sub.2 OH   CH(CH.sub.3)OCH.sub.3                                2.0528                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH(CH.sub.3)OCH.sub.3                                2.0529                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH(CH.sub.3)OCH.sub.3                                2.0530                                                                               H     C.sub.6 H.sub.5                                                                              CH(CH.sub.3)OCH.sub.3                                2.0531                                                                               H     CH.sub.2 Cl   CH(CH.sub.3)OCH.sub.3                                2.0532                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH(CH.sub.3)OCH.sub.3                                2.0533                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH(CH.sub.3)OCH.sub.3                                ______________________________________                                    

                  TABLE 2.06                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.0601                                                                               H     H             CH.sub.2 OC.sub.2 H.sub.5                                                              m.p. 144-151° C.                      2.0602                                                                               H     CH.sub.3      CH.sub.2 OC.sub.2 H.sub.5                                                              m.p. 159-162° C.                      2.0603                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.5                                                              m.p. 143-145° C.                      2.0604                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.2 OC.sub.2 H.sub.5                            2.0605                                                                               H     OCH.sub.3     CH.sub.2 OC.sub.2 H.sub.5                            2.0606                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.5                            2.0607                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH.sub.2 OC.sub.2 H.sub.5                            2.0608                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH.sub.2 OC.sub.2 H.sub.5                            2.0609                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH.sub.2 OC.sub.2 H.sub.5                            2.0610                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH.sub.2 OC.sub.2 H.sub.5                            2.0611                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH.sub.2 OC.sub.2 H.sub.5                            2.0612                                                                               H     OCHF.sub.2    CH.sub.2 OC.sub.2 H.sub.5                            2.0613                                                                               H     OCF.sub.3     CH.sub.2 OC.sub.2 H.sub.5                            2.0614                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.2 OC.sub.2 H.sub.5                            2.0615                                                                               H     OC.sub.6 H.sub. 5                                                                            CH.sub.2 OC.sub.2 H.sub.5                            2.0616                                                                               H     CF.sub.3      CH.sub.2 OC.sub.2 H.sub.5                            2.0617                                                                               H     Br            CH.sub.2 OC.sub.2 H.sub.5                            2.0618                                                                               H     Cl            CH.sub.2 OC.sub.2 H.sub.5                            2.0619                                                                               H     F             CH.sub.2 OC.sub.2 H.sub.5                            2.0620                                                                               H     SCH.sub.3     CH.sub.2 OC.sub.2 H.sub.5                            2.0621                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.5                            2.0622                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OC.sub.2 H.sub.5                            2.0623                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                            2.0624                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OC.sub.2 H.sub.5                            2.0625                                                                               H     NO.sub.2      CH.sub.2 OC.sub.2 H.sub.5                            2.0626                                                                               H     CN            CH.sub.2 OC.sub.2 H.sub.5                            2.0627                                                                               H     CH.sub.2 OH   CH.sub.2 OC.sub.2 H.sub.5                            2.0628                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OC.sub.2 H.sub.5                            2.0629                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.2 OC.sub.2 H.sub.5                            2.0630                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.5                            2.0631                                                                               H     CH.sub.2 Cl   CH.sub.2 OC.sub.2 H.sub.5                            2.0632                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OC.sub.2 H.sub.5                            2.0633                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.2 H.sub.5                            ______________________________________                                    

                  TABLE 2.07                                                       ______________________________________                                         No.   X     Y             Z          phys. data                                ______________________________________                                         2.0701                                                                               H     H             CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0702                                                                               H     CH.sub.3      CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0703                                                                               H     C.sub.2 H.sub.5                                                                              CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0704                                                                               H     C.sub.3 H.sub.7                                                                              CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0705                                                                               H     OCH.sub.3     CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0706                                                                               H     OC.sub.2 H.sub.5                                                                             CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0707                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0708                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0709                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0710                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0711                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0712                                                                               H     OCHF.sub.2    CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0713                                                                               H     OCF.sub.3     CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0714                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0715                                                                               H     OC.sub.6 H.sub.5                                                                             CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0716                                                                               H     CF.sub.3      CH(CH.sub.3)OC.sub.2 H.sub. 5                        2.0717                                                                               H     Br            CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0718                                                                               H     Cl            CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0719                                                                               H     F             CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0720                                                                               H     SCH.sub.3     CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0721                                                                               H     SC.sub.2 H.sub.5                                                                             CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0722                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0723                                                                               H     SO.sub.2 CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0724                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0725                                                                               H     NO.sub.2      CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0726                                                                               H     CN            CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0727                                                                               H     CH.sub.2 OH   CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0728                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0729                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0730                                                                               H     C.sub.6 H.sub.5                                                                              CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0731                                                                               H     CH.sub.2 Cl   CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0732                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH(CH.sub.3)OC.sub.2 H.sub.5                         2.0733                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH(CH.sub.3)OC.sub.2 H.sub.5                         ______________________________________                                    

                  TABLE 2.08                                                       ______________________________________                                         No.   X     Y             Z         phys. data                                 ______________________________________                                         2.0801                                                                               H     H             C(CH.sub.3).sub.2 OCH.sub.3                          2.0802                                                                               H     CH.sub.3      C(CH.sub.3).sub.2 OCH.sub.3                          2.0803                                                                               H     C.sub.2 H.sub.5                                                                              C(CH.sub.3).sub.2 OCH.sub.3                          2.0804                                                                               H     C.sub.3 H.sub.7                                                                              C(CH.sub.3).sub.2 OCH.sub.3                          2.0805                                                                               H     OCH.sub.3     C(CH.sub.3).sub.2 OCH.sub.3                          2.0806                                                                               H     OC.sub.2 H.sub.5                                                                             C(CH.sub.3).sub.2 OCH.sub.3                          2.0807                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    C(CH.sub.3).sub.2 OCH.sub.3                          2.0808                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  C(CH.sub.3).sub.2 OCH.sub.3                          2.0809                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 C(CH.sub.3).sub.2 OCH.sub.3                          2.0810                                                                               H     OCH.sub.2 CH═CHCl                                                                        C(CH.sub.3).sub.2 OCH.sub.3                          2.0811                                                                               H     OCH.sub.2 C.tbd.CH                                                                           C(CH.sub.3).sub.2 OCH.sub.3                          2.0812                                                                               H     OCHF.sub.2    C(CH.sub.3).sub.2 OCH.sub.3                          2.0813                                                                               H     OCF.sub.3     C(CH.sub.3).sub.2 OCH.sub.3                          2.0814                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        C(CH.sub.3).sub.2 OCH.sub.3                          2.0815                                                                               H     OC.sub.6 H.sub.5                                                                             C(CH.sub.3).sub.2 OCH.sub.3                          2.0816                                                                               H     CF.sub.3      C(CH.sub.3).sub.2 OCH.sub. 3                         2.0817                                                                               H     Br            C(CH.sub.3).sub.2 OCH.sub.3                          2.0818                                                                               H     Cl            C(CH.sub.3).sub.2 OCH.sub.3                          2.0819                                                                               H     F             C(CH.sub.3).sub.2 OCH.sub.3                          2.0820                                                                               H     SCH.sub.3     C(CH.sub.3).sub.2 OCH.sub.3                          2.0821                                                                               H     SC.sub.2 H.sub.5                                                                             C(CH.sub.3).sub.2 OCH.sub.3                          2.0822                                                                               H     SC.sub.3 H.sub.7 -n                                                                          C(CH.sub.3).sub.2 OCH.sub.3                          2.0823                                                                               H     SO.sub.2 CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                          2.0824                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     C(CH.sub.3).sub.2 OCH.sub.3                          2.0825                                                                               H     NO.sub.2      C(CH.sub.3).sub.2 OCH.sub.3                          2.0826                                                                               H     CN            C(CH.sub.3).sub.2 OCH.sub.3                          2.0827                                                                               H     CH.sub.2 OH   C(CH.sub.3).sub.2 OCH.sub.3                          2.0828                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         C(CH.sub.3).sub.2 OCH.sub.3                          2.0829                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                C(CH.sub.3).sub.2 OCH.sub.3                          2.0830                                                                               H     C.sub.6 H.sub.5                                                                              C(CH.sub.3).sub.2 OCH.sub.3                          2.0831                                                                               H     CH.sub.2 Cl   C(CH.sub.3).sub.2 OCH.sub.3                          2.0832                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         C(CH.sub.3).sub.2 OCH.sub.3                          2.0833                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                C(CH.sub.3).sub.2 OCH.sub.3                          ______________________________________                                    

                  TABLE 2.09                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.0901                                                                               H     H             CH.sub.2 OC.sub.3 H.sub.7                            2.0902                                                                               H     CH.sub.3      CH.sub.2 OC.sub.3 H.sub.7                            2.0903                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.3 H.sub.7                            2.0904                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.2 OC.sub.3 H.sub.7                            2.0905                                                                               H     OCH.sub.3     CH.sub.2 OC.sub.3 H.sub.7                            2.0906                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.3 H.sub.7                            2.0907                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH.sub.2 OC.sub.3 H.sub.7                            2.0908                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH.sub.2 OC.sub.3 H.sub.7                            2.0909                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH.sub.2 OC.sub.3 H.sub.7                            2.0910                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH.sub.2 OC.sub.3 H.sub.7                            2.0911                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH.sub.2 OC.sub.3 H.sub.7                            2.0912                                                                               H     OCHF.sub.2    CH.sub.2 OC.sub.3 H.sub.7                            2.0913                                                                               H     OCF.sub.3     CH.sub.2 OC.sub.3 H.sub.7                            2.0914                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.2 OC.sub.3 H.sub.7                            2.0915                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.2 OC.sub.3 H.sub.7                            2.0916                                                                               H     CF.sub.3      CH.sub.2 OC.sub.3 H.sub. 7                           2.0917                                                                               H     Br            CH.sub.2 OC.sub.3 H.sub.7                            2.0918                                                                               H     Cl            CH.sub.2 OC.sub.3 H.sub.7                            2.0919                                                                               H     F             CH.sub.2 OC.sub.3 H.sub.7                            2.0920                                                                               H     SCH.sub.3     CH.sub.2 OC.sub.3 H.sub.7                            2.0921                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.3 H.sub.7                            2.0922                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OC.sub.3 H.sub.7                            2.0923                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.2 OC.sub.3 H.sub.7                            2.0924                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OC.sub.3 H.sub.7                            2.0925                                                                               H     NO.sub.2      CH.sub.2 OC.sub.3 H.sub.7                            2.0926                                                                               H     CN            CH.sub.2 OC.sub.3 H.sub.7                            2.0927                                                                               H     CH.sub.2 OH   CH.sub.2 OC.sub.3 H.sub.7                            2.0928                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OC.sub.3 H.sub.7                            2.0929                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.2 OC.sub.3 H.sub.7                            2.0930                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.3 H.sub.7                            2.0931                                                                               H     CH.sub.2 Cl   CH.sub.2 OC.sub.3 H.sub.7                            2.0932                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OC.sub.3 H.sub.7                            2.0933                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.3 H.sub.7                            ______________________________________                                    

                  TABLE 2.10                                                       ______________________________________                                                                               phys.                                    No.   X     Y             Z           data                                     ______________________________________                                         2.1001                                                                               H     H             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                                                         m.p.                                                                           149-                                                                           154° C.                           2.1002                                                                               H     CH.sub.3      C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1003                                                                               H     C.sub.2 H.sub.5                                                                              C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1004                                                                               H     C.sub.3 H.sub.7                                                                              C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1005                                                                               H     OCH.sub.3     C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1006                                                                               H     OC.sub.2 H.sub.5                                                                             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1007                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1008                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1009                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1010                                                                               H     OCH.sub.2 CH═CHCl                                                                        C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1011                                                                               H     OCH.sub.2 C.tbd.CH                                                                           C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1012                                                                               H     OCHF.sub.2    C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1013                                                                               H     OCF.sub.3     C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1014                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1015                                                                               H     OC.sub.6 H.sub.5                                                                             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1016                                                                               H     CF.sub.3      C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1017                                                                               H     Br            C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1018                                                                               H     Cl            C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1019                                                                               H     F             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1020                                                                               H     SCH.sub.3     C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1021                                                                               H     SC.sub.2 H.sub.5                                                                             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1022                                                                               H     SC.sub.3 H.sub.7 -n                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1023                                                                               H     SO.sub.2 CH.sub.3                                                                            C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1024                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1025                                                                               H     NO.sub.2      C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1026                                                                               H     CN            C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1027                                                                               H     CH.sub.2 OH   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1028                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1029                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1030                                                                               H     C.sub.6 H.sub. 5                                                                             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1031                                                                               H     CH.sub.2 Cl   C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1032                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   2.1033                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                   ______________________________________                                    

                  TABLE 2.11                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.1101                                                                               H     H             CH.sub.2 OC.sub.6 H.sub.5                                                              m.p. 157-162° C.                      2.1102                                                                               H     CH.sub.3      CH.sub.2 OC.sub.6 H.sub.5                            2.1103                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.6 H.sub.5                            2.1104                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.2 OC.sub.6 H.sub.5                            2.1105                                                                               H     OCH.sub.3     CH.sub.2 OC.sub.6 H.sub.5                            2.1106                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.6 H.sub.5                            2.1107                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH.sub.2 OC.sub.6 H.sub.5                            2.1108                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH.sub.2 OC.sub.6 H.sub.5                            2.1109                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH.sub.2 OC.sub.6 H.sub.5                            2.1110                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH.sub.2 OC.sub.6 H.sub.5                            2.1111                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH.sub.2 OC.sub.6 H.sub.5                            2.1112                                                                               H     OCHF.sub.2    CH.sub.2 OC.sub.6 H.sub.5                            2.1113                                                                               H     OCF.sub.3     CH.sub.2 OC.sub.6 H.sub.5                            2.1114                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.2 OC.sub.6 H.sub.5                            2.1115                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.2 OC.sub.6 H.sub.5                            2.1116                                                                               H     CF.sub. 3     CH.sub.2 OC.sub.6 H.sub.5                            2.1117                                                                               H     Br            CH.sub.2 OC.sub.6 H.sub.5                            2.1118                                                                               H     Cl            CH.sub.2 OC.sub.6 H.sub.5                            2.1119                                                                               H     F             CH.sub.2 OC.sub.6 H.sub.5                            2.1120                                                                               H     SCH.sub.3     CH.sub.2 OC.sub.6 H.sub.5                            2.1121                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.6 H.sub.5                            2.1122                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OC.sub.6 H.sub.5                            2.1123                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.2 OC.sub.6 H.sub.5                            2.1124                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OC.sub.6 H.sub.5                            2.1125                                                                               H     NO.sub.2      CH.sub.2 OC.sub.6 H.sub.5                            2.1126                                                                               H     CN            CH.sub.2 OC.sub.6 H.sub.5                            2.1127                                                                               H     CH.sub.2 OH   CH.sub.2 OC.sub.6 H.sub.5                            2.1128                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OC.sub.6 H.sub.5                            2.1129                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.2 OC.sub.6 H.sub.5                            2.1130                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.6 H.sub.5                            2.1131                                                                               H     CH.sub.2 Cl   CH.sub.2 OC.sub.6 H.sub.5                            2.1132                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OC.sub.6 H.sub.5                            2.1133                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.6 H.sub.5                            ______________________________________                                    

                  TABLE 2.12                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.1201                                                                               H     H             furan-2-yl                                                                             m.p. 197-199° C.                      2.1202                                                                               H     CH.sub.3      furan-2-yl                                           2.1203                                                                               H     C.sub.2 H.sub.5                                                                              furan-2-yl                                           2.1204                                                                               H     C.sub.3 H.sub.7                                                                              furan-2-yl                                           2.1205                                                                               H     OCH.sub.3     furan-2-yl                                           2.1206                                                                               H     OC.sub.2 H.sub.5                                                                             furan-2-yl                                           2.1207                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    furan-2-yl                                           2.1208                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  furan-2-yl                                           2.1209                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 furan-2-yl                                           2.1210                                                                               H     OCH.sub.2 CH═CHCl                                                                        furan-2-yl                                           2.1211                                                                               H     OCH.sub.2 C.tbd.CH                                                                           furan-2-yl                                           2.1212                                                                               H     OCHF.sub.2    furan-2-yl                                           2.1213                                                                               H     OCF.sub.3     furan-2-yl                                           2.1214                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        furan-2-yl                                           2.1215                                                                               H     OC.sub.6 H.sub.5                                                                             furan-2-yl                                           2.1216                                                                               H     CF.sub.3      furan-2-yl                                           2.1217                                                                               H     Br            furan-2-yl                                           2.1218                                                                               H     Cl            furan-2-yl                                           2.1219                                                                               H     F             furan-2-yl                                           2.1220                                                                               H     SCH.sub.3     furan-2-yl                                           2.1221                                                                               H     SC.sub.2 H.sub.5                                                                             furan-2-yl                                           2.1222                                                                               H     SC.sub.3 H.sub.7 -n                                                                          furan-2-yl                                           2.1223                                                                               H     SO.sub.2 CH.sub.3                                                                            furan-2-yl                                           2.1224                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     furan-2-yl                                           2.1225                                                                               H     NO.sub.2      furan-2-yl                                           2.1226                                                                               H     CN            furan-2-yl                                           2.1227                                                                               H     CH.sub.2 OH   furan-2-yl                                           2.1228                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         furan-2-yl                                           2.1229                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                furan-2-yl                                           2.1230                                                                               H     C.sub.6 H.sub.5                                                                              furan-2-yl                                           2.1231                                                                               H     CH.sub.2 Cl   furan-2-yl                                           2.1232                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         furan-2-yl                                           2.1233                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                furan-2-yl                                           ______________________________________                                    

                  TABLE 2.13                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.1301                                                                               H     H             dioxan-2-yl                                                                            m.p. 203-206° C.                      2.1302                                                                               H     CH.sub.3      dioxan-2-yl                                          2.1303                                                                               H     C.sub.2 H.sub.5                                                                              dioxan-2-yl                                          2.1304                                                                               H     C.sub.3 H.sub.7                                                                              dioxan-2-yl                                          2.1305                                                                               H     OCH.sub.3     dioxan-2-yl                                          2.1306                                                                               H     OC.sub.2 H.sub.5                                                                             dioxan-2-yl                                          2.1307                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    dioxan-2-yl                                          2.1308                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  dioxan-2-yl                                          2.1309                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 dioxan-2-yl                                          2.1310                                                                               H     OCH.sub.2 CH═CHCl                                                                        dioxan-2-yl                                          2.1311                                                                               H     OCH.sub.2 C.tbd.CH                                                                           dioxan-2-yl                                          2.1312                                                                               H     OCHF.sub.2    dioxan-2-yl                                          2.1313                                                                               H     OCF.sub.3     dioxan-2-yl                                          2.1314                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        dioxan-2-yl                                          2.1315                                                                               H     OC.sub.6 H.sub.5                                                                             dioxan-2-yl                                          2.1316                                                                               H     CF.sub.3      dioxan-2-yl                                          2.1317                                                                               H     Br            dioxan-2-yl                                          2.1318                                                                               H     Cl            dioxan-2-yl                                          2.1319                                                                               H     F             dioxan-2-yl                                          2.1320                                                                               H     SCH.sub.3     dioxan-2-yl                                          2.1321                                                                               H     SC.sub.2 H.sub.5                                                                             dioxan-2-yl                                          2.1322                                                                               H     SC.sub.3 H.sub.7 -n                                                                          dioxan-2-yl                                          2.1323                                                                               H     SO.sub.2 CH.sub.3                                                                            dioxan-2-yl                                          2.1324                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     dioxan-2-yl                                          2.1325                                                                               H     NO.sub.2      dioxan-2-yl                                          2.1326                                                                               H     CN            dioxan-2-yl                                          2.1327                                                                               H     CH.sub.2 OH   dioxan-2-yl                                          2.1328                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         dioxan-2-yl                                          2.1329                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                dioxan-2-yl                                          2.1330                                                                               H     C.sub.6 H.sub.5                                                                              dioxan-2-yl                                          2.1331                                                                               H     CH.sub.2 Cl   dioxan-2-yl                                          2.1332                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         dioxan-2-yl                                          2.1333                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                dioxan-2-yl                                          ______________________________________                                    

                  TABLE 2.14                                                       ______________________________________                                         No.   X     Y             Z          phys. data                                ______________________________________                                         2.1401                                                                               H     H             CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                                                       resin                                     2.1402                                                                               H     CH.sub.3      CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1403                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1404                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1405                                                                               H     OCH.sub.3     CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1406                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1407                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1408                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1409                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1410                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1411                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1412                                                                               H     OCHF.sub.2    CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1413                                                                               H     OCF.sub.3x    CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1414                                                                               H     OCF.sub.2 CHFCF.sub. 3                                                                       CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1415                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1416                                                                               H     CF.sub.3      CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1417                                                                               H     Br            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1418                                                                               H     Cl            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1419                                                                               H     F             CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1420                                                                               H     SCH.sub.3     CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1421                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1422                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1423                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1424                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1425                                                                               H     NO.sub.2      CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1426                                                                               H     CN            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1427                                                                               H     CH.sub.2 OH   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1428                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1429                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub. 2 OC.sub.2 H.sub.4 OCH.sub.3                 2.1430                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1431                                                                               H     CH.sub.2 Cl   CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1432                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  2.1433                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                  ______________________________________                                    

                  TABLE 2.15                                                       ______________________________________                                                                                 phys.                                  No.   X     Y             Z             data                                   ______________________________________                                         2.1501                                                                               H     H             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1502                                                                               H     CH.sub.3      CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1503                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1504                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1505                                                                               H     OCH.sub.3     CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1506                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1507                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1508                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1509                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1510                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1511                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1512                                                                               H     OCHF.sub.2    CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1513                                                                               H     OCF.sub.3     CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1514                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1515                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1516                                                                               H     CF.sub.3      CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1517                                                                               H     Br            CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1518                                                                               H     Cl            CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1519                                                                               H     F             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1520                                                                               H     SCH.sub.3     CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1521                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1522                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1523                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1524                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1525                                                                               H     NO.sub.2      CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1526                                                                               H     CN            CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1527                                                                               H     CH.sub.2 OH   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1528                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1529                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1530                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1531                                                                               H     CH.sub.2 Cl   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.1532                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            2.11533                                                                              H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            ______________________________________                                    

                  TABLE 2.16                                                       ______________________________________                                                                               phys.                                    No.   X     Y             Z           data                                     ______________________________________                                         2.1601                                                                               H     H             CH.sub.2 OCH.sub.2 CONH.sub.2                                                              wax                                      2.1602                                                                               H     CH.sub.3      CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1603                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1604                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1605                                                                               H     OCH.sub.3     CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1606                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1607                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1608                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1609                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1610                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1611                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1612                                                                               H     OCHF.sub.2    CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1613                                                                               H     OCF.sub.3     CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1614                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1615                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1616                                                                               H     CF.sub. 3     CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1617                                                                               H     Br            CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1618                                                                               H     Cl            CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1619                                                                               H     F             CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1620                                                                               H     SCH.sub.3     CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1621                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1622                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1623                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1624                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1625                                                                               H     NO.sub.2      CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1626                                                                               H     CN            CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1627                                                                               H     CH.sub.2 OH   CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1628                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1629                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1630                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1631                                                                               H     CH.sub.2 Cl   CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1632                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OCH.sub.2 CONH.sub.2                        2.1633                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OCH.sub.2 CONH.sub.2                        ______________________________________                                    

                  TABLE 2.17                                                       ______________________________________                                         No.   X     Y             Z        phys. data                                  ______________________________________                                         2.1701                                                                               H     H             thiophen-2-yl                                                                           m.p.                                                                           247-248° C.                          2.1702                                                                               H     CH.sub.3      thiophen-2-yl                                        2.1703                                                                               H     C.sub.2 H.sub.5                                                                              thiophen-2-yl                                        2.1704                                                                               H     C.sub.3 H.sub.7                                                                              thiophen-2-yl                                        2.1705                                                                               H     OCH.sub.3     thiophen-2-yl                                        2.1706                                                                               H     OC.sub.2 H.sub.5                                                                             thiophen-2-yl                                        2.1707                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    thiophen-2-yl                                        2.1708                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  thiophen-2-yl                                        2.1700                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 thiophen-2-yl                                        2.1710                                                                               H     OCH.sub.2 CH═CHCl                                                                        thiophen-2-yl                                        2.1711                                                                               H     OCH.sub.2 C.tbd.CH                                                                           thiophen-2-yl                                        2.1712                                                                               H     OCHF.sub.2    thiophen-2-yl                                        2.1713                                                                               H     OCF.sub.3     thiophen-2-yl                                        2.1714                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        thiophen-2-yl                                        2.1715                                                                               H     OC.sub.6 H.sub.5                                                                             thiophen-2-yl                                        2.1716                                                                               H     CF.sub.3      thiophen-2-yl                                        2.1717                                                                               H     Br            thiophen-2-yl                                        2.1718                                                                               H     Cl            thiophen-2-yl                                        2.1719                                                                               H     F             thiophen-2-yl                                        2.1720                                                                               H     SCH.sub.3     thiophen-2-yl                                        2.1721                                                                               H     SC.sub.2 H.sub.5                                                                             thiophen-2-yl                                        2.1722                                                                               H     SC.sub.3 H.sub.7 -n                                                                          thiophen-2-yl                                        2.1723                                                                               H     SO.sub.2 CH.sub.3                                                                            thiophen-2-yl                                        2.1724                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     thiophen-2-yl                                        2.1725                                                                               H     NO.sub.2      thiophen-2-yl                                        2.1726                                                                               H     CN            thiophen-2-yl                                        2.1727                                                                               H     CH.sub.2 OH   thiophen-2-yl                                        2.1728                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         thiophen-2-yl                                        2.1729                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                thiophen-2-yl                                        2.1730                                                                               H     C.sub.6 H.sub.5                                                                              thiophen-2-yl                                        2.1731                                                                               H     CH.sub.2 Cl   thiophen-2-yl                                        2.1732                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         thiophen-2-yl                                        2.1733                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                thiophen-2-yl                                        ______________________________________                                    

                  TABLE 2.18                                                       ______________________________________                                         No.   X     Y             Z        phys. data                                  ______________________________________                                         2.1801                                                                               H     H             thiophen-3-yl                                                                           m.p.                                                                           247-248° C.                          2.1802                                                                               H     CH.sub.3      thiophen-3-yl                                        2.1803                                                                               H     C.sub.2 H.sub.5                                                                              thiophen-3-yl                                        2.1804                                                                               H     C.sub.3 H.sub.7                                                                              thiophen-3-yl                                        2.1805                                                                               H     OCH.sub.3     thiophen-3-yl                                        2.1806                                                                               H     OC.sub.2 H.sub.5                                                                             thiophen-3-yl                                        2.1807                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    thiophen-3-yl                                        2.1808                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  thiophen-3-yl                                        2.1809                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 thiophen-3-yl                                        2.1810                                                                               H     OCH.sub.2 CH═CHCl                                                                        thiophen-3-yl                                        2.1811                                                                               H     OCH.sub.2 C.tbd.CH                                                                           thiophen-3-yl                                        2.1812                                                                               H     OCHF.sub.2    thiophen-3-yl                                        2.1813                                                                               H     OCF.sub.3     thiophen-3-yl                                        2.1814                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        thiophen-3-yl                                        2.1815                                                                               H     OC.sub.6 H.sub.5                                                                             thiophen-3-yl                                        2.1816                                                                               H     CF.sub.3      thiophen-3-yl                                        2.1817                                                                               H     Br            thiophen-3-yl                                        2.1818                                                                               H     Cl            thiophen-3-yl                                        2.1819                                                                               H     F             thiophen-3-yl                                        2.1820                                                                               H     SCH.sub.3     thiophen-3-yl                                        2.1821                                                                               H     SC.sub.2 H.sub.5                                                                             thiophen-3-yl                                        2.1822                                                                               H     SC.sub.3 H.sub.7 -n                                                                          thiophen-3-yl                                        2.1823                                                                               H     SO.sub.2 CH.sub.3                                                                            thiophen-3-yl                                        2.1824                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     thiophen-3-yl                                        2.1825                                                                               H     NO.sub.2      thiophen-3-yl                                        2.1826                                                                               H     CN            thiophen-3-yl                                        2.1827                                                                               H     CH.sub.2 OH   thiophen-3-yl                                        2.1828                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         thiophen-3-yl                                        2.1829                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                thiophen-3-yl                                        2.1830                                                                               H     C.sub.6 H.sub.5                                                                              thiophen-3-yl                                        2.1831                                                                               H     CH.sub.2 Cl   thiophen-3-yl                                        2.1832                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         thiophen-3-yl                                        2.1833                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                thiophen-3-yl                                        ______________________________________                                    

                  TABLE 2.19                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.1901                                                                               H     H             pyridin-3-yl                                                                           m.p. 240-242° C.                      2.1902                                                                               H     CH.sub.3      pyridin-3-yl                                         2.1903                                                                               H     C.sub.2 H.sub.5                                                                              pyridin-3-yl                                         2.1904                                                                               H     C.sub.3 H.sub.7                                                                              pyridin-3-yl                                         2.1905                                                                               H     OCH.sub.3     pyridin-3-yl                                         2.1906                                                                               H     OC.sub.2 H.sub.5                                                                             pyridin-3-yl                                         2.1907                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    pyridin-3-yl                                         2.1908                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  pyridin-3-yl                                         2.1909                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 pyridin-3-yl                                         2.1910                                                                               H     OCH.sub.2 CH═CHCl                                                                        pyridin-3-yl                                         2.1911                                                                               H     OCH.sub.2 C.tbd.CH                                                                           pyridin-3-yl                                         2.1912                                                                               H     OCHF.sub.2    pyridin-3-yl                                         2.1913                                                                               H     OCF.sub.3     pyridin-3-yl                                         2.1914                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        pyridin-3-yl                                         2.1915                                                                               H     OC.sub.6 H.sub.5                                                                             pyridin-3-yl                                         2.1916                                                                               H     CF.sub.3      pyridin-3-yl                                         2.1917                                                                               H     Br            pyridin-3-yl                                         2.1918                                                                               H     Cl            pyridin-3-yl                                         2.1919                                                                               H     F             pyridin-3-yl                                         2.1920                                                                               H     SCH.sub.3     pyridin-3-yl                                         2.1921                                                                               H     SC.sub.2 H.sub.5                                                                             pyridin-3-yl                                         2.1922                                                                               H     SC.sub.3 H.sub.7 -n                                                                          pyridin-3-yl                                         2.1923                                                                               H     SO.sub.2 CH.sub.3                                                                            pyridin-3-yl                                         2.1924                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     pyridin-3-yl                                         2.1925                                                                               H     NO.sub.2      pyridin-3-yl                                         2.1926                                                                               H     CN            pyridin-3-yl                                         2.1927                                                                               H     CH.sub.2 OH   pyridin-3-yl                                         2.1928                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         pyridin-3-yl                                         2.1929                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                pyridin-3-yl                                         2.1930                                                                               H     C.sub.6 H.sub.5                                                                              pyridin-3-yl                                         2.1931                                                                               H     CH.sub.2 Cl   pyridin-3-yl                                         2.1932                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         pyridin-3-yl                                         2.1933                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                pyridin-3-yl                                         ______________________________________                                    

                  TABLE 2.20                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.2001                                                                               H     H             pyridin-4-yl                                         2.2002                                                                               H     CH.sub.3      pyridin-4-yl                                         2.2003                                                                               H     C.sub.2 H.sub.5                                                                              pyridin-4-yl                                         2.2004                                                                               H     C.sub.3 H.sub.7                                                                              pyridin-4-yl                                         2.2005                                                                               H     OCH.sub.3     pyridin-4-yl                                         2.2006                                                                               H     OC.sub.2 H.sub.5                                                                             pyridin-4-yl                                         2.2007                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    pyridin-4-yl                                         2.2008                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  pyridin-4-yl                                         2.2009                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 pyridin-4-yl                                         2.2010                                                                               H     OCH.sub.2 CH═CHCl                                                                        pyridin-4-yl                                         2.2011                                                                               H     OCH.sub.2 C.tbd.CH                                                                           pyridin-4-yl                                         2.2012                                                                               H     OCHF.sub.2    pyridin-4-yl                                         2.2013                                                                               H     OCF.sub.3     pyridin-4-yl                                         2.2014                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        pyridin-4-yl                                         2.2015                                                                               H     OC.sub.6 H.sub.5                                                                             pyridin-4-yl                                         2.2016                                                                               H     CF.sub.3      pyridin-4-yl                                         2.2017                                                                               H     Br            pyridin-4-yl                                         2.2018                                                                               H     Cl            pyridin-4-yl                                         2.2019                                                                               H     F             pyridin-4-yl                                         2.2020                                                                               H     SCH.sub.3     pyridin-4-yl                                         2.2021                                                                               H     SC.sub.2 H.sub.5                                                                             pyridin-4-yl                                         2.2022                                                                               H     SC.sub.3 H.sub.7 -n                                                                          pyridin-4-yl                                         2.2023                                                                               H     SO.sub.2 CH.sub.3                                                                            pyridin-4-yl                                         2.2024                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     pyridin-4-yl                                         2.2025                                                                               H     NO.sub.2      pyridin-4-yl                                         2.2026                                                                               H     CN            pyridin-4-yl                                         2.2027                                                                               H     CH.sub.2 OH   pyridin-4-yl                                         2.2028                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         pyridin-4-yl                                         2.2029                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                pyridin-4-yl                                         2.2030                                                                               H     C.sub.6 H.sub.5                                                                              pyridin-4-yl                                         2.2031                                                                               H     CH.sub.2 Cl   pyridin-4-yl                                         2.2032                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         pyridin-4-yl                                         2.2033                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                pyridin-4-yl                                         ______________________________________                                    

                  TABLE 2.21                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.2101                                                                               H     H             pyridin-2-yl                                         2.2102                                                                               H     CH.sub.3      pyridin-2-yl                                         2.2103                                                                               H     C.sub.2 H.sub.5                                                                              pyridin-2-yl                                         2.2104                                                                               H     C.sub.3 H.sub.7                                                                              pyridin-2-yl                                         2.2105                                                                               H     OCH.sub.3     pyridin-2-yl                                         2.2106                                                                               H     OC.sub.2 H.sub.5                                                                             pyridin-2-yl                                         2.2107                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    pyridin-2-yl                                         2.2108                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  pyridin-2-yl                                         2.2109                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 pyridin-2-yl                                         2.2110                                                                               H     OCH.sub.2 CH═CHCl                                                                        pyridin-2-yl                                         2.2111                                                                               H     OCH.sub.2 C.tbd.CH                                                                           pyridin-2-yl                                         2.2112                                                                               H     OCHF.sub.2    pyridin-2-yl                                         2.2113                                                                               H     OCF.sub.3     pyridin-2-yl                                         2.2114                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        pyridin-2-yl                                         2.2115                                                                               H     OC.sub.6 H.sub.5                                                                             pyridin-2-yl                                         2.2116                                                                               H     CF.sub.3      pyridin-2-yl                                         2.2117                                                                               H     Br            pyridin-2-yl                                         2.2118                                                                               H     Cl            pyridin-2-yl                                         2.2119                                                                               H     F             pyridin-2-yl                                         2.2120                                                                               H     SCH.sub.3     pyridin-2-yl                                         2.2121                                                                               H     SC.sub.2 H.sub.5                                                                             pyridin-2-yl                                         2.2122                                                                               H     SC.sub.3 H.sub.7 -n                                                                          pyridin-2-yl                                         2.2123                                                                               H     SO.sub.2 CH.sub.3                                                                            pyridin-2-yl                                         2.2124                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     pyridin-2-yl                                         2.2125                                                                               H     NO.sub.2      pyridin-2-yl                                         2.2126                                                                               H     CN            pyridin-2-yl                                         2.2127                                                                               H     CH.sub.2 OH   pyridin-2-yl                                         2.2128                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         pyridin-2-yl                                         2.2129                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                pyridin-2-yl                                         2.2130                                                                               H     C.sub.6 H.sub.5                                                                              pyridin-2-yl                                         2.2131                                                                               H     CH.sub.2 Cl   pyridin-2-yl                                         2.2132                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         pyridin-2-yl                                         2.2133                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                pyridin-2-yl                                         ______________________________________                                    

                  TABLE 2.22                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.2201                                                                               H     H             furan-3-yl                                           2.2202                                                                               H     CH.sub.3      furan-3-yl                                           2.2203                                                                               H     C.sub.2 H.sub.5                                                                              furan-3-yl                                           2.2204                                                                               H     C.sub.3 H.sub.7                                                                              furan-3-yl                                           2.2205                                                                               H     OCH.sub.3     furan-3-yl                                           2.2206                                                                               H     OC.sub.2 H.sub.5                                                                             furan-3-yl                                           2.2207                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    furan-3-yl                                           2.2208                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  furan-3-yl                                           2.2209                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 furan-3-yl                                           2.2210                                                                               H     OCH.sub.2 CH═CHCl                                                                        furan-3-yl                                           2.2211                                                                               H     OCH.sub.2 C.tbd.CH                                                                           furan-3-yl                                           2.2212                                                                               H     OCHF.sub.2    furan-3-yl                                           2.2213                                                                               H     OCF.sub.3     furan-3-yl                                           2.2214                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        furan-3-yl                                           2.2215                                                                               H     OC.sub.6 H.sub.5                                                                             furan-3-yl                                           2.2216                                                                               H     CF.sub.3      furan-3-yl                                           2.2217                                                                               H     Br            furan-3-yl                                           2.2218                                                                               H     Cl            furan-3-yl                                           2.2219                                                                               H     F             furan-3-yl                                           2.2220                                                                               H     SCH.sub.3     furan-3-yl                                           2.2221                                                                               H     SC.sub.2 H.sub.5                                                                             furan-3-yl                                           2.2222                                                                               H     SC.sub.3 H.sub.7 -n                                                                          furan-3-yl                                           2.2223                                                                               H     SO.sub.2 CH.sub.3                                                                            furan-3-yl                                           2.2224                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     furan-3-yl                                           2.2225                                                                               H     NO.sub.2      furan-3-yl                                           2.2226                                                                               H     CN            furan-3-yl                                           2.2227                                                                               H     CH.sub.2 OH   furan-3-yl                                           2.2228                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         furan-3-yl                                           2.2229                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                furan-3-yl                                           2.2230                                                                               H     C.sub.6 H.sub.5                                                                              furan-3-yl                                           2.2231                                                                               H     CH.sub.2 Cl   furan-3-yl                                           2.2232                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         furan-3-yl                                           2.2233                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                furan-3-yl                                           ______________________________________                                    

                  TABLE 2.23                                                       ______________________________________                                                                                phys.                                   No.   X     Y             Z            data                                    ______________________________________                                         2.2301                                                                               H     H             4-methylpyrimidin-6-yl                               2.2302                                                                               H     CH.sub.3      4-methylpyrimidin-6-yl                               2.2303                                                                               H     C.sub.2 H.sub.5                                                                              4-methylpyrimidin-6-yl                               2.2304                                                                               H     C.sub.3 H.sub.7                                                                              4-methylpyrimidin-6-yl                               2.2305                                                                               H     OCH.sub.3     4-methylpyrimidin-6-yl                               2.2306                                                                               H     OC.sub.2 H.sub.5                                                                             4-methylpyrimidin-6-yl                               2.2307                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    4-methylpyrimidin-6-yl                               2.2308                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  4-methylpyrimidin-6-yl                               2.2309                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 4-methylpyrimidin-6-yl                               2.2310                                                                               H     OCH.sub.2 CH═CHCl                                                                        4-methylpyrimidin-6-yl                               2.2311                                                                               H     OCH.sub.2 C.tbd.CH                                                                           4-methylpyrimidin-6-yl                               2.2312                                                                               H     OCHF.sub.2    4-methylpyrimidin-6-yl                               2.2313                                                                               H     OCF.sub.3     4-methylpyrimidin-6-yl                               2.2314                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        4-methylpyrimidin-6-yl                               2.2315                                                                               H     OC.sub.6 H.sub.5                                                                             4-methylpyrimidin-6-yl                               2.2316                                                                               H     CF.sub.3      4-methylpyrimidin-6-yl                               2.2317                                                                               H     Br            4-methylpyrimidin-6-yl                               2.2318                                                                               H     Cl            4-methylpyrimidin-6-yl                               2.2319                                                                               H     F             4-methylpyrimidin-6-yl                               2.2320                                                                               H     SCH.sub.3     4-methylpyrimidin-6-yl                               2.2321                                                                               H     SC.sub.2 H.sub.5                                                                             4-methylpyrimidin-6-yl                               2.2322                                                                               H     SC.sub.3 H.sub.7 -n                                                                          4-methylpyrimidin-6-yl                               2.2323                                                                               H     SO.sub.2 CH.sub.3                                                                            4-methylpyrimidin-6-yl                               2.2324                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     4-methylpyrimidin-6-yl                               2.2325                                                                               H     NO.sub.2      4-methylpyrimidin-6-yl                               2.2326                                                                               H     CN            4-methylpyrimidin-6-yl                               2.2327                                                                               H     CH.sub.2 OH   4-methylpyrimidin-6-yl                               2.2328                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         4-methylpyrimidin-6-yl                               2.2329                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                4-methylpyrimidin-6-yl                               2.2330                                                                               H     C.sub.6 H.sub.5                                                                              4-methylpyrimidin-6-yl                               2.2331                                                                               H     CH.sub.2 Cl   4-methylpyrimidin-6-yl                               2.2332                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         4-methylpyrimidin-6-yl                               2.2333                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                4-methylpyrimidin-6-yl                               ______________________________________                                    

                  TABLE 2.24                                                       ______________________________________                                         No.   X     Y             Z         phys. data                                 ______________________________________                                         2.2401                                                                               H     H             1,3,5-triazin-2-yl                                   2.2402                                                                               H     CH.sub.3      1,3,5-triazin-2-yl                                   2.2403                                                                               H     C.sub.2 H.sub.5                                                                              1,3,5-triazin-2-yl                                   2.2404                                                                               H     C.sub.3 H.sub.7                                                                              1,3,5-triazin-2-yl                                   2.2405                                                                               H     OCH.sub.3     1,3,5-triazin-2-yl                                   2.2406                                                                               H     OC.sub.2 H.sub.5                                                                             1,3,5-triazin-2-yl                                   2.2407                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    1,3,5-triazin-2-yl                                   2.2408                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  1,3,5-triazin-2-yl                                   2.2409                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 1,3,5-triazin-2-yl                                   2.2410                                                                               H     OCH.sub.2 CH═CHCl                                                                        1,3,5-triazin-2-yl                                   2.2411                                                                               H     OCH.sub.2 C.tbd.CH                                                                           1,3,5-triazin-2-yl                                   2.2412                                                                               H     OCHF.sub.2    1,3,5-triazin-2-yl                                   2.2413                                                                               H     OCF.sub.3     1,3,5-triazin-2-yl                                   2.2414                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        1,3,5-triazin-2-yl                                   2.2415                                                                               H     OC.sub.6 H.sub.5                                                                             1,3,5-triazin-2-yl                                   2.2416                                                                               H     CF.sub.3      1,3,5-triazin-2-yl                                   2.2417                                                                               H     Br            1,3,5-triazin-2-yl                                   2.2418                                                                               H     Cl            1,3,5-triazin-2-yl                                   2.2419                                                                               H     F             1,3,5-triazin-2-yl                                   2.2420                                                                               H     SCH.sub.3     1,3,5-triazin-2-yl                                   2.2421                                                                               H     SC.sub.2 H.sub.5                                                                             1,3,5-triazin-2-yl                                   2.2422                                                                               H     SC.sub.3 H.sub.7 -n                                                                          1,3,5-triazin-2-yl                                   2.2423                                                                               H     SO.sub.2 CH.sub.3                                                                            1,3,5-triazin-2-yl                                   2.2424                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     1,3,5-triazin-2-yl                                   2.2426                                                                               H     NO.sub.2      1,3,5-triazin-2-yl                                   2.2426                                                                               H     CN            1,3,5-triazin-2-yl                                   2.2427                                                                               H     CH.sub.2 OH   1,3,5-triazin-2-yl                                   2.2428                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         1,3,5-triazin-2-yl                                   2.2429                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                1,3,5-triazin-2-yl                                   2.2430                                                                               H     C.sub.6 H.sub.5                                                                              1,3,5-triazin-2-yl                                   2.2431                                                                               H     CH.sub.2 Cl   1,3,5-triazin-2-yl                                   2.2432                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         1,3,5-triazin-2-yl                                   2.2433                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                1,3,5-triazin-2-yl                                   ______________________________________                                    

                  TABLE 2.25                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.2501                                                                               H     H             oxazol-2-yl                                          2.2502                                                                               H     CH.sub.3      oxazol-2-yl                                          2.2503                                                                               H     C.sub.2 H.sub.5                                                                              oxazol-2-yl                                          2.2504                                                                               H     C.sub.3 H.sub.7                                                                              oxazol-2-yl                                          2.2505                                                                               H     OCH.sub.3     oxazol-2-yl                                          2.2506                                                                               H     OC.sub.2 H.sub.5                                                                             oxazol-2-yl                                          2.2507                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    oxazol-2-yl                                          2.2508                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  oxazol-2-yl                                          2.2509                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 oxazol-2-yl                                          2.2510                                                                               H     OCH.sub.2 CH═CHCl                                                                        oxazol-2-yl                                          2.2511                                                                               H     OCH.sub.2 C.tbd.CH                                                                           oxazol-2-yl                                          2.2512                                                                               H     OCHF.sub.2    oxazol-2-yl                                          2.2513                                                                               H     OCF.sub.3     oxazol-2-yl                                          2.2514                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        oxazol-2-yl                                          2.2515                                                                               H     OC.sub.6 H.sub.5                                                                             oxazol-2-yl                                          2.2516                                                                               H     CF.sub.3      oxazol-2-yl                                          2.2517                                                                               H     Br            oxazol-2-yl                                          2.2518                                                                               H     Cl            oxazol-2-yl                                          2.2519                                                                               H     F             oxazol-2-yl                                          2.2520                                                                               H     SCH.sub.3     oxazol-2-yl                                          2.2521                                                                               H     SC.sub.2 H.sub.5                                                                             oxazol-2-yl                                          2.2522                                                                               H     SC.sub.3 H.sub.7 -n                                                                          oxazol-2-yl                                          2.2523                                                                               H     SO.sub.2 CH.sub.3                                                                            oxazol-2-yl                                          2.2524                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     oxazol-2-yl                                          2.2525                                                                               H     NO.sub.2      oxazol-2-yl                                          2.2526                                                                               H     CN            oxazol-2-yl                                          2.2527                                                                               H     CH.sub.2 OH   oxazol-2-yl                                          2.2528                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         oxazol-2-yl                                          2.2529                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                oxazol-2-yl                                          2.2530                                                                               H     C.sub.6 H.sub.5                                                                              oxazol-2-yl                                          2.2531                                                                               H     CH.sub.2 Cl   oxazol-2-yl                                          2.2532                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         oxazol-2-yl                                          2.2533                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                oxazol-2-yl                                          ______________________________________                                    

                  TABLE 2.26                                                       ______________________________________                                         No.   X     Y             Z       phys. data                                   ______________________________________                                         2.2601                                                                               H     H             triazol-2-yl                                         2.2602                                                                               H     CH.sub.3      triazol-2-yl                                         2.2603                                                                               H     C.sub.2 H.sub.5                                                                              triazol-2-yl                                         2.2604                                                                               H     C.sub.3 H.sub.7                                                                              triazol-2-yl                                         2.2605                                                                               H     OCH.sub.3     triazol-2-yl                                         2.2606                                                                               H     OC.sub.2 H.sub.5                                                                             triazol-2-yl                                         2.2607                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    triazol-2-yl                                         2.2608                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  triazol-2-yl                                         2.2609                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 triazol-2-yl                                         2.2610                                                                               H     OCH.sub.2 CH═CHCl                                                                        triazol-2-yl                                         2.2611                                                                               H     OCH.sub.2 C.tbd.CH                                                                           triazol-2-yl                                         2.2612                                                                               H     OCHF.sub.2    triazol-2-yl                                         2.2613                                                                               H     OCF.sub.3     triazol-2-yl                                         2.2614                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        triazol-2-yl                                         2.2615                                                                               H     OC.sub.6 H.sub.5                                                                             triazol-2-yl                                         2.2616                                                                               H     CF.sub.3      triazol-2-yl                                         2.2617                                                                               H     Br            triazol-2-yl                                         2.2618                                                                               H     Cl            triazol-2-yl                                         2.2619                                                                               H     F             triazol-2-yl                                         2.2620                                                                               H     SCH.sub.3     triazol-2-yl                                         2.2621                                                                               H     SC.sub.2 H.sub.5                                                                             triazol-2-yl                                         2.2622                                                                               H     SC.sub.3 H.sub.7 -n                                                                          triazol-2-yl                                         2.2623                                                                               H     SO.sub.2 CH.sub.3                                                                            triazol-2-yl                                         2.2624                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     triazol-2-yl                                         2.2625                                                                               H     NO.sub.2      triazol-2-yl                                         2.2626                                                                               H     CN            triazol-2-yl                                         2.2627                                                                               H     CH.sub.2 OH   triazol-2-yl                                         2.2628                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         triazol-2-yl                                         2.2629                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                triazol-2-yl                                         2.2630                                                                               H     C.sub.6 H.sub.5                                                                              triazol-2-yl                                         2.2631                                                                               H     CH.sub.2 Cl   triazol-2-yl                                         2.2632                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         triazol-2-yl                                         2.2633                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                triazol-2-yl                                         ______________________________________                                    

EXAMPLE 9 Preparation of 8-cyclopropyl-2,7-dimethyl-3,5-dioxo-2-isopropyl-imidazo[2',1':1,2]5H-pyrrolo[3,4-6]pyridine ##STR46##

A solution of 13 g of 6-cyclopropyl-5-methyl-2-(5-isopropyl-5-methyl-4-oxo-imidazolin-2-yl)-pyridine-3-carboxylic acid and 9.3 g of dicyclohexylcarbodiimide in 200 ml of methylene chloride is stirred for one hour at room temperature. The reaction mixture is then filtered and the filtrate is concentrated. The residue is stirred with ether and crystallises. In this manner 7.2 g of the title compound having a melting point of 184°-187° C. are obtained.

EXAMPLE 10 Preparation of 7-ethyl-3,5-dioxo-2-isopropyl-8-methoxymethyl-2-methyl-imidazo[2,1:5,1]5H-pyrrolo[3,4-e]pyridine ##STR47##

4.9 g of dicyclohexylcarbodiimide are added to a solution of 7.9 g of 5-ethyl-6-methoxymethyl-2-(5-isopropyl-5-methyl-4-oxo-imidazolin-2-yl)-pyridine-3-carboxylic acid in 150 ml of methylene chloride and the reaction mixture is stirred for one hour at room temperature. It is then filtered, the filtrate is concentrated and the residue is stirred with ether. In this manner 3.4 g of crystalline title product having a melting point of 121°-123° C. are obtained.

The tricyclic compounds of Tables 3.01 to 3.16 are prepared in a manner analogous to that described in Examples 9 and 10. ##STR48##

                  TABLE 3.00                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         3.0001                                                                               H     H              C.sub.3 H.sub.5 (cyclo)                             3.0002                                                                               H     CH.sub.3       C.sub.3 H.sub.5 (cyclo)                                                                 m.p.                                                                           187-192° C.                         3.0003                                                                               H     C.sub.2 H.sub.5                                                                               C.sub.3 H.sub.5 (cyclo)                                                                 m.p.                                                                           170-180° C.                         3.0004                                                                               H     C.sub.3 H.sub.7                                                                               C.sub.3 H.sub.5 (cyclo)                             3.0005                                                                               H     OCH.sub.3      C.sub.3 H.sub.5 (cyclo)                             3.0006                                                                               H     OC.sub.2 H.sub.5                                                                              C.sub.3 H.sub.5 (cyclo)                             3.0007                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    C.sub.3 H.sub.5 (cyclo)                             3.0008                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  C.sub.3 H.sub.5 (cyclo)                             3.0009                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 C.sub.3 H.sub.5 (cyclo)                             3.0010                                                                               H     OCH.sub.2 CH═ CHCl                                                                        C.sub.3 H.sub.5 (cyclo)                             3.0011                                                                               H     OCH.sub.2 C.tbd. CH                                                                           C.sub.3 H.sub.5 (cyclo)                             3.0012                                                                               H     OCHF.sub.2     C.sub.3 H.sub.5 (cyclo)                             3.0013                                                                               H     OCF.sub.3      C.sub.3 H.sub.5 (cyclo)                             3.0014                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         C.sub.3 H.sub.5 (cyclo)                             3.0015                                                                               H     OC.sub.6 H.sub. 5                                                                             C.sub.3 H.sub.5 (cyclo)                             3.0016                                                                               H     CF.sub.3       C.sub.3 H.sub.5 (cyclo)                             3.0017                                                                               H     Br             C.sub.3 H.sub.5 (cyclo)                             3.0018                                                                               H     Cl             C.sub.3 H.sub.5 (cyclo)                             3.0019                                                                               H     F              C.sub.3 H.sub.5 (cyclo)                             3.0020                                                                               H     SCH.sub.3      C.sub.3 H.sub.5 (cyclo)                             3.0021                                                                               H     SC.sub.2 H.sub.5                                                                              C.sub.3 H.sub.5 (cyclo)                             3.0022                                                                               H     SC.sub.3 H.sub.7 -n                                                                           C.sub.3 H.sub.5 (cyclo)                             3.0023                                                                               H     SO.sub.2 CH.sub.3                                                                             C.sub.3 H.sub.5 (cyclo)                             3.0024                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      C.sub.3 H.sub.5 (cyclo)                             3.0025                                                                               H     NO.sub.2       C.sub.3 H.sub.5 (cyclo)                             3.0026                                                                               H     CN             C.sub.3 H.sub.5 (cyclo)                             3.0027                                                                               H     CH.sub.2 OH    C.sub.3 H.sub.5 (cyclo)                             3.0028                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          C.sub.3 H.sub.5 (cyclo)                             3.0029                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 C.sub.3 H.sub.5 (cyclo)                             3.0030                                                                               H     C.sub.6 H.sub.5                                                                               C.sub.3 H.sub.5 (cyclo)                             3.0031                                                                               H     CH.sub.2 Cl    C.sub.3 H.sub.5 (cyclo)                             3.0032                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          C.sub.3 H.sub.5 (cyclo)                             3.0033                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 C.sub.3 H.sub.5 (cyclo)                             ______________________________________                                    

                  TABLE 3.01                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         3.0101                                                                               H     H              C.sub.4 H.sub.7 (cyclo)                             3.0102                                                                               H     CH.sub.3       C.sub.4 H.sub.7 (cyclo)                             3.0103                                                                               H     C.sub.2 H.sub.5                                                                               C.sub.4 H.sub.7 (cyclo)                             3.0104                                                                               H     C.sub.3 H.sub.7                                                                               C.sub.4 H.sub.7 (cyclo)                             3.0105                                                                               H     OCH.sub.3      C.sub.4 H.sub.7 (cyclo)                             3.0106                                                                               H     OC.sub.2 H.sub.5                                                                              C.sub.4 H.sub.7 (cyclo)                             3.0107                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    C.sub.4 H.sub.7 (cyclo)                             3.0108                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  C.sub.4 H.sub.7 (cyclo)                             3.0109                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 C.sub.4 H.sub.7 (cyclo)                             3.0110                                                                               H     OCH.sub.2 CH═ CHCl                                                                        C.sub.4 H.sub.7 (cyclo)                             3.0111                                                                               H     OCH.sub.2 C.tbd. CH                                                                           C.sub.4 H.sub.7 (cyclo)                             3.0112                                                                               H     OCHF.sub.2     C.sub.4 H.sub.7 (cyclo)                             3.0113                                                                               H     OCF.sub.3      C.sub.4 H.sub.7 (cyclo)                             3.0114                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         C.sub.4 H.sub.7 (cyclo)                             3.0115                                                                               H     OC.sub.6 H.sub.5                                                                              C.sub.4 H.sub.7 (cyclo)                             3.0116                                                                               H     CF.sub.3       C.sub.4 H.sub.7 (cyclo)                             3.0117                                                                               H     Br             C.sub.4 H.sub.7 (cyclo)                             3.0118                                                                               H     Cl             C.sub.4 H.sub.7 (cyclo)                             3.0119                                                                               H     F              C.sub.4 H.sub.7 (cyclo)                             3.0120                                                                               H     SCH.sub.3      C.sub.4 H.sub.7 (cyclo)                             3.0121                                                                               H     SC.sub.2 H.sub.5                                                                              C.sub.4 H.sub.7 (cyclo)                             3.0122                                                                               H     SC.sub.3 H.sub.7 -n                                                                           C.sub.4 H.sub.7 (cyclo)                             3.0123                                                                               H     SO.sub.2 CH.sub.3                                                                             C.sub.4 H.sub.7 (cyclo)                             3.0124                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      C.sub.4 H.sub.7 (cyclo)                             3.0125                                                                               H     NO.sub.2       C.sub.4 H.sub.7 (cyclo)                             3.0126                                                                               H     CN             C.sub.4 H.sub.7 (cyclo)                             3.0127                                                                               H     CH.sub.2 OH    C.sub.4 H.sub.7 (cyclo)                             3.0128                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          C.sub.4 H.sub.7 (cyclo)                             3.0129                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 C.sub.4 H.sub.7 (cyclo)                             3.0130                                                                               H     C.sub.6 H.sub.5                                                                               C.sub.4 H.sub.7 (cyclo)                             3.0131                                                                               H     CH.sub.2 Cl    C.sub.4 H.sub.7 (cyclo)                             3.0132                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          C.sub.4 H.sub.7 (cyclo)                             3.0133                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 C.sub.4 H.sub.7 (cyclo)                             ______________________________________                                    

                  TABLE 3.02                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         3.0201                                                                               H     H              C.sub.5 H.sub.9 (cyclo)                             3.0202                                                                               H     CH.sub.3       C.sub.5 H.sub.9 (cyclo)                             3.0203                                                                               H     C.sub.2 H.sub.5                                                                               C.sub.5 H.sub.9 (cyclo)                             3.0204                                                                               H     C.sub.3 H.sub.7                                                                               C.sub.5 H.sub.9 (cyclo)                             3.0205                                                                               H     OCH.sub.3      C.sub.5 H.sub.9 (cyclo)                             3.0206                                                                               H     OC.sub.2 H.sub.5                                                                              C.sub.5 H.sub.9 (cyclo)                             3.0207                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    C.sub.5 H.sub.9 (cyclo)                             3.0208                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  C.sub.5 H.sub.9 (cyclo)                             3.0209                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 C.sub.5 H.sub.9 (cyclo)                             3.0210                                                                               H     OCH.sub.2 CH═ CHCl                                                                        C.sub.5 H.sub.9 (cyclo)                             3.0211                                                                               H     OCH.sub.2 C.tbd. CH                                                                           C.sub.5 H.sub.9 (cyclo)                             3.0212                                                                               H     OCHF.sub.2     C.sub.5 H.sub.9 (cyclo)                             3.0213                                                                               H     OCF.sub.3      C.sub.5 H.sub.9 (cyclo)                             3.0214                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         C.sub.5 H.sub.9 (cyclo)                             3.0215                                                                               H     OC.sub.6 H.sub.5                                                                              C.sub.5 H.sub.9 (cyclo)                             3.0216                                                                               H     CF.sub.3       C.sub.5 H.sub.9 (cyclo)                             3.0217                                                                               H     Br             C.sub.5 H.sub.9 (cyclo)                             3.0218                                                                               H     Cl             C.sub.5 H.sub.9 (cyclo)                             3.0219                                                                               H     F              C.sub.5 H.sub.9 (cyclo)                             3.0220                                                                               H     SCH.sub.3      C.sub.5 H.sub.9 (cyclo)                             3.0221                                                                               H     SC.sub.2 H.sub.5                                                                              C.sub.5 H.sub.9 (cyclo)                             3.0222                                                                               H     SC.sub.3 H.sub.7 -n                                                                           C.sub.5 H.sub.9 (cyclo)                             3.0223                                                                               H     SO.sub.2 CH.sub.3                                                                             C.sub.5 H.sub.9 (cyclo)                             3.0224                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      C.sub.5 H.sub.9 (cyclo)                             3.0225                                                                               H     NO.sub.2       C.sub.5 H.sub.9 (cyclo)                             3.0226                                                                               H     CN             C.sub.5 H.sub.9 (cyclo)                             3.0227                                                                               H     CH.sub.2 OH    C.sub.5 H.sub.9 (cyclo)                             3.0228                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          C.sub.5 H.sub.9 (cyclo)                             3.0229                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 C.sub.5 H.sub.9 (cyclo)                             3.0230                                                                               H     C.sub.6 H.sub.5                                                                               C.sub.5 H.sub.9 (cyclo)                             3.0231                                                                               H     CH.sub.2 Cl    C.sub.5 H.sub.9 (cyclo)                             3.0232                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          C.sub.5 H.sub.9 (cyclo)                             3.0233                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 C.sub.5 H.sub.9 (cyclo)                             ______________________________________                                    

                  TABLE 3.03                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         3.0301                                                                               H     H              C.sub.6 H.sub.11 (cyclo)                            3.0302                                                                               H     CH.sub.3       C.sub.6 H.sub.11 (cyclo)                            3.0303                                                                               H     C.sub.2 H.sub.5                                                                               C.sub.6 H.sub.11 (cyclo)                            3.0304                                                                               H     C.sub.3 H.sub.7                                                                               C.sub.6 H.sub.11 (cyclo)                            3.0305                                                                               H     OCH.sub.3      C.sub.6 H.sub.11 (cyclo)                            3.0306                                                                               H     OC.sub.2 H.sub.5                                                                              C.sub.6 H.sub.11 (cyclo)                            3.0307                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    C.sub.6 H.sub.11 (cyclo)                            3.0308                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  C.sub.6 H.sub.11 (cyclo)                            3.0309                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 C.sub.6 H.sub.11 (cyclo)                            3.0310                                                                               H     OCH.sub.2 CH═ CHCl                                                                        C.sub.6 H.sub.11 (cyclo)                            3.0311                                                                               H     OCH.sub.2 C.tbd. CH                                                                           C.sub.6 H.sub.11 (cyclo)                            3.0312                                                                               H     OCHF.sub.2     C.sub.6 H.sub.11 (cyclo)                            3.0313                                                                               H     OCF.sub.3      C.sub.6 H.sub.11 (cyclo)                            3.0314                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         C.sub.6 H.sub.11 (cyclo)                            3.0315                                                                               H     OC.sub.6 H.sub.5                                                                              C.sub.6 H.sub.11 (cyclo)                            3.0316                                                                               H     CF.sub.3       C.sub.6 H.sub.11 (cyclo)                            3.0317                                                                               H     Br             C.sub.6 H.sub.11 (cyclo)                            3.0318                                                                               H     Cl             C.sub.6 H.sub.11 (cyclo)                            3.0319                                                                               H     F              C.sub.6 H.sub.11 (cyclo)                            3.0320                                                                               H     SCH.sub.3      C.sub.6 H.sub.11 (cyclo)                            3.0321                                                                               H     SC.sub.2 H.sub.5                                                                              C.sub.6 H.sub.11 (cyclo)                            3.0322                                                                               H     SC.sub.3 H.sub.7 -n                                                                           C.sub.6 H.sub.11 (cyclo)                            3.0323                                                                               H     SO.sub.2 CH.sub.3                                                                             C.sub.6 H.sub.11 (cyclo)                            3.0324                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      C.sub.6 H.sub.11 (cyclo)                            3.0325                                                                               H     NO.sub.2       C.sub.6 H.sub.11 (cyclo)                            3.0326                                                                               H     CN             C.sub.6 H.sub.11 (cyclo)                            3.0327                                                                               H     CH.sub.2 OH    C.sub.6 H.sub.11 (cyclo)                            3.0328                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          C.sub.6 H.sub.11 (cyclo)                            3.0329                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 C.sub.6 H.sub.11 (cyclo)                            3.0330                                                                               H     C.sub.6 H.sub.5                                                                               C.sub.6 H.sub.11 (cyclo)                            3.0331                                                                               H     CH.sub.2 Cl    C.sub.6 H.sub.11 (cyclo)                            3.0332                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          C.sub.6 H.sub.11 (cyclo)                            3.0333                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 C.sub.6 H.sub.11 (cyclo)                            ______________________________________                                    

                  TABLE 3.04                                                       ______________________________________                                         No.    X      Y              Z       phys. data                                ______________________________________                                         3.0401 H      H              CH.sub.2 OCH.sub.3                                3.0402 H      CH.sub.3       CH.sub.2 OCH.sub.3                                3.0403 H      C.sub.2 H.sub.5                                                                               CH.sub.2 OCH.sub.3                                                                     121-123° C.                        3.0404 H      C.sub.3 H.sub.7                                                                               CH.sub.2 OCH.sub.3                                3.0405 H      OCH.sub.3      CH.sub.2 OCH.sub.3                                3.0406 H      OC.sub.2 H.sub.5                                                                              CH.sub.2 OCH.sub.3                                3.0407 H      OCH.sub.2 CH═ CH.sub.2                                                                    CH.sub.2 OCH.sub.3                                3.0408 H      OCH.sub.2 CH═ CHCH.sub.3                                                                  CH.sub.2 OCH.sub.3                                3.0409 H      OCH.sub.2 C(Cl)═ CH.sub.2                                                                 CH.sub.2 OCH.sub.3                                3.0410 H      OCH.sub.2 CH═ CHCl                                                                        CH.sub.2 OCH.sub.3                                3.0411 H      OCH.sub.2 C.tbd. CH                                                                           CH.sub.2 OCH.sub.3                                3.0412 H      OCHF.sub.2     CH.sub.2 OCH.sub.3                                3.0413 H      OCF.sub.3      CH.sub.2 OCH.sub.3                                3.0414 H      OCF.sub.2 CHFCF.sub.3                                                                         CH.sub.2 OCH.sub.3                                3.0415 H      OC.sub.6 H.sub.5                                                                              CH.sub.2 OCH.sub.3                                3.0416 H      CF.sub.3       CH.sub.2 OCH.sub.3                                3.0417 H      Br             CH.sub.2 OCH.sub.3                                3.0418 H      Cl             CH.sub.2 OCH.sub.3                                3.0419 H      F              CH.sub.2 OCH.sub.3                                3.0420 H      SCH.sub.3      CH.sub.2 OCH.sub.3                                3.0421 H      SC.sub.2 H.sub.5                                                                              CH.sub.2 OCH.sub.3                                3.0422 H      SC.sub.3 H.sub.7 -n                                                                           CH.sub.2 OCH.sub.3                                3.0423 H      SO.sub.2 CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                3.0424 H      SO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.2 OCH.sub.3                                3.0425 H      NO.sub.2       CH.sub.2 OCH.sub.3                                3.0426 H      CN             CH.sub.2 OCH.sub.3                                3.0427 H      CH.sub.2 OH    CH.sub.2 OCH.sub.3                                3.0428 H      CH.sub.2 CH.sub.2 OH                                                                          CH.sub.2 OCH.sub.3                                3.0429 H      CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 CH.sub.2 OCH.sub.3                                3.0430 H      C.sub.6 H.sub.5                                                                               CH.sub.2 OCH.sub.3                                3.0431 H      CH.sub.2 Cl    CH.sub.2 OCH.sub.3                                3.0432 H      CH.sub.2 CH.sub.2 Cl                                                                          CH.sub.2 OCH.sub.3                                3.0433 H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 CH.sub.2 OCH.sub.3                                ______________________________________                                    

                  TABLE 3.05                                                       ______________________________________                                         No.   X     Y              Z         phys. data                                ______________________________________                                         3.0501                                                                               H     H              CH(CH.sub.3)OCH.sub.3                               3.0502                                                                               H     CH.sub.3       CH(CH.sub.3)OCH.sub.3                               3.0503                                                                               H     C.sub.2 H.sub.5                                                                               CH(CH.sub.3)OCH.sub.3                               3.0504                                                                               H     C.sub.3 H.sub.7                                                                               CH(CH.sub.3)OCH.sub.3                               3.0505                                                                               H     OCH.sub.3      CH(CH.sub.3)OCH.sub.3                               3.0506                                                                               H     OC.sub.2 H.sub.5                                                                              CH(CH.sub.3)OCH.sub.3                               3.0507                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    CH(CH.sub.3)OCH.sub.3                               3.0508                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  CH(CH.sub.3)OCH.sub.3                               3.0509                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 CH(CH.sub.3)OCH.sub.3                               3.0510                                                                               H     OCH.sub.2 CH═ CHCl                                                                        CH(CH.sub.3)OCH.sub.3                               3.0511                                                                               H     OCH.sub.2 C.tbd. CH                                                                           CH(CH.sub.3)OCH.sub.3                               3.0512                                                                               H     OCHF.sub.2     CH(CH.sub.3)OCH.sub.3                               3.0513                                                                               H     OCF.sub.3      CH(CH.sub.3)OCH.sub.3                               3.0514                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         CH(CH.sub.3)OCH.sub.3                               3.0515                                                                               H     OC.sub.6 H.sub.5                                                                              CH(CH.sub.3)OCH.sub.3                               3.0516                                                                               H     CF.sub.3       CH(CH.sub.3)OCH.sub.3                               3.0517                                                                               H     Br             CH(CH.sub.3)OCH.sub.3                               3.0518                                                                               H     Cl             CH(CH.sub.3)OCH.sub.3                               3.0519                                                                               H     F              CH(CH.sub.3 )OCH.sub.3                              3.0520                                                                               H     SCH.sub.3      CH(CH.sub.3)OCH.sub.3                               3.0521                                                                               H     SC.sub.2 H.sub.5                                                                              CH(CH.sub.3)OCH.sub.3                               3.0522                                                                               H     SC.sub.3 H.sub.7 -n                                                                           CH(CH.sub.3)OCH.sub.3                               3.0523                                                                               H     SO.sub.2 CH.sub.3                                                                             CH(CH.sub.3)OCH.sub.3                               3.0524                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      CH(CH.sub.3)OCH.sub.3                               3.0525                                                                               H     NO.sub.2       CH(CH.sub.3)OCH.sub.3                               3.0526                                                                               H     CN             CH(CH.sub.3)OCH.sub.3                               3.0527                                                                               H     CH.sub.2 OH    CH(CH.sub.3)OCH.sub.3                               3.0528                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          CH(CH.sub.3)OCH.sub.3                               3.0529                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 CH(CH.sub.3)OCH.sub.3                               3.0530                                                                               H     C.sub.6 H.sub.5                                                                               CH(CH.sub.3)OCH.sub.3                               3.0531                                                                               H     CH.sub.2 Cl    CH(CH.sub.3)OCH.sub.3                               3.0532                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          CH(CH.sub.3)OCH.sub.3                               3.0533                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 CH(CH.sub.3)OCH.sub.3                               ______________________________________                                    

                  TABLE 3.06                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         3.0601                                                                               H     H              CH.sub.2 OC.sub.2 H.sub.5                                                               resin                                      3.0602                                                                               H     CH.sub.3       CH.sub.2 OC.sub.2 H.sub.5                           3.0603                                                                               H     C.sub.2 H.sub.5                                                                               CH.sub.2 OC.sub.2 H.sub.5                           3.0604                                                                               H     C.sub.3 H.sub.7                                                                               CH.sub.2 OC.sub.2 H.sub.5                           3.0605                                                                               H     OCH.sub.3      CH.sub.2 OC.sub.2 H.sub.5                           3.0606                                                                               H     OC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.5                           3.0607                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    CH.sub.2 OC.sub.2 H.sub.5                           3.0608                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  CH.sub.2 OC.sub.2 H.sub.5                           3.0609                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 CH.sub.2 OC.sub.2 H.sub.5                           3.0610                                                                               H     OCH.sub.2 CH═ CHCl                                                                        CH.sub.2 OC.sub.2 H.sub.5                           3.0611                                                                               H     OCH.sub.2 C.tbd. CH                                                                           CH.sub.2 OC.sub.2 H.sub.5                           3.0612                                                                               H     OCHF.sub.2     CH.sub.2 OC.sub.2 H.sub.5                           3.0613                                                                               H     OCF.sub.3      CH.sub.2 OC.sub.2 H.sub.5                           3.0614                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         CH.sub.2 OC.sub.2 H.sub.5                           3.0615                                                                               H     OC.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub. 2 H.sub.5                          3.0616                                                                               H     CF.sub.3       CH.sub.2 OC.sub.2 H.sub.5                           3.0617                                                                               H     Br             CH.sub.2 OC.sub.2 H.sub.5                           3.0618                                                                               H     Cl             CH.sub.2 OC.sub.2 H.sub.5                           3.0619                                                                               H     F              CH.sub.2 OC.sub.2 H.sub.5                           3.0620                                                                               H     SCH.sub.3      CH.sub.2 OC.sub.2 H.sub.5                           3.0621                                                                               H     SC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.5                           3.0622                                                                               H     SC.sub.3 H.sub.7 -n                                                                           CH.sub.2 OC.sub.2 H.sub.5                           3.0623                                                                               H     SO.sub.2 CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                           3.0624                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.2 OC.sub.2 H.sub.5                           3.0625                                                                               H     NO.sub.2       CH.sub.2 OC.sub.2 H.sub.5                           3.0626                                                                               H     CN             CH.sub.2 OC.sub.2 H.sub.5                           3.0627                                                                               H     CH.sub.2 OH    CH.sub.2 OC.sub.2 H.sub.5                           3.0628                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          CH.sub.2 OC.sub.2 H.sub.5                           3.0629                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 CH.sub.2 OC.sub.2 H.sub.5                           3.0630                                                                               H     C.sub.6 H.sub.5                                                                               CH.sub.2 OC.sub.2 H.sub.5                           3.0631                                                                               H     CH.sub.2 Cl    CH.sub.2 OC.sub.2 H.sub.5                           3.0632                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          CH.sub.2 OC.sub.2 H.sub.5                           3.0633                                                                               H     CH.sub.2 CH.sub. 2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.2 H.sub.5                           ______________________________________                                    

                  TABLE 3.07                                                       ______________________________________                                                                                phys.                                   No.   X      Y              Z          data                                    ______________________________________                                         3.0701                                                                               H      H              CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0702                                                                               H      CH.sub.3       CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0703                                                                               H      C.sub.2 H.sub.5                                                                               CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0704                                                                               H      C.sub.3 H.sub.7                                                                               CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0705                                                                               H      OCH.sub.3      CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0706                                                                               H      OC.sub.2 H.sub.5                                                                              CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0707                                                                               H      OCH.sub.2 CH═ CH.sub.2                                                                    CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0708                                                                               H      OCH.sub.2 CH═ CHCH.sub.3                                                                  CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0709                                                                               H      OCH.sub.2 C(Cl)═ CH.sub.2                                                                 CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0710                                                                               H      OCH.sub.2 CH═ CHCl                                                                        CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0711                                                                               H      OCH.sub.2 C.tbd. CH                                                                           CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0712                                                                               H      OCHF.sub.2     CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0713                                                                               H      OCF.sub.3      CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0714                                                                               H      OCF.sub.2 CHFCF.sub.3                                                                         CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0715                                                                               H      OC.sub.6 H.sub. 5                                                                             CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0716                                                                               H      CF.sub.3       CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0717                                                                               H      Br             CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0718                                                                               H      Cl             CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0719                                                                               H      F              CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0720                                                                               H      SCH.sub.3      CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0721                                                                               H      SC.sub.2 H.sub.5                                                                              CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0722                                                                               H      SC.sub.3 H.sub.7 -n                                                                           CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0723                                                                               H      SO.sub.2 CH.sub.3                                                                             CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0724                                                                               H      SO.sub.2 C.sub.2 H.sub.5                                                                      CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0725                                                                               H      NO.sub.2       CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0726                                                                               H      CN             CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0727                                                                               H      CH.sub.2 OH    CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0728                                                                               H      CH.sub.2 CH.sub.2 OH                                                                          CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0729                                                                               H      CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0730                                                                               H      C.sub.6 H.sub.5                                                                               CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0731                                                                               H      CH.sub.2 Cl    CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0732                                                                               H      CH.sub.2 CH.sub.2 Cl                                                                          CH(CH.sub.3)OC.sub.2 H.sub.5                       3.0733                                                                               H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 CH(CH.sub.3)OC.sub.2 H.sub.5                       ______________________________________                                    

                  TABLE 3.08                                                       ______________________________________                                         No.   X     Y              Z         phys. data                                ______________________________________                                         3.0801                                                                               H     H              C(CH.sub.3).sub.2 OCH.sub.3                         3.0802                                                                               H     CH.sub.3       C(CH.sub.3).sub.2 OCH.sub.3                         3.0803                                                                               H     C.sub.2 H.sub.5                                                                               C(CH.sub.3).sub.2 OCH.sub.3                         3.0804                                                                               H     C.sub.3 H.sub.7                                                                               C(CH.sub.3).sub.2 OCH.sub.3                         3.0805                                                                               H     OCH.sub.3      C(CH.sub.3).sub.2 OCH.sub.3                         3.0806                                                                               H     OC.sub.2 H.sub.5                                                                              C(CH.sub.3).sub.2 OCH.sub.3                         3.0807                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    C(CH.sub.3).sub.2 OCH.sub.3                         3.0808                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  C(CH.sub.3).sub.2 OCH.sub.3                         3.0809                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 C(CH.sub.3).sub.2 OCH.sub.3                         3.0810                                                                               H     OCH.sub.2 CH═ CHCl                                                                        C(CH.sub.3).sub.2 OCH.sub.3                         3.0811                                                                               H     OCH.sub.2 C.tbd. CH                                                                           C(CH.sub.3).sub.2 OCH.sub.3                         3.0812                                                                               H     OCHF.sub.2     C(CH.sub.3).sub.2 OCH.sub.3                         3.0813                                                                               H     OCF.sub.3      C(CH.sub.3).sub.2 OCH.sub.3                         3.0814                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         C(CH.sub.3).sub.2 OCH.sub.3                         3.0815                                                                               H     OC.sub.6 H.sub.5                                                                              C(CH.sub.3).sub. 2 OCH.sub.3                        3.0816                                                                               H     CF.sub.3       C(CH.sub.3).sub.2 OCH.sub.3                         3.0817                                                                               H     Br             C(CH.sub.3).sub.2 OCH.sub.3                         3.0818                                                                               H     Cl             C(CH.sub.3).sub.2 OCH.sub.3                         3.0819                                                                               H     F              C(CH.sub.3).sub.2 OCH.sub.3                         3.0820                                                                               H     SCH.sub.3      C(CH.sub.3).sub.2 OCH.sub.3                         3.0821                                                                               H     SC.sub.2 H.sub.5                                                                              C(CH.sub.3).sub.2 OCH.sub.3                         3.0822                                                                               H     SC.sub.3 H.sub.7 -n                                                                           C(CH.sub.3).sub.2 OCH.sub.3                         3.0823                                                                               H     SO.sub.2 CH.sub.3                                                                             C(CH.sub.3).sub.2 OCH.sub.3                         3.0824                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      C(CH.sub.3).sub.2 OCH.sub.3                         3.0825                                                                               H     NO.sub.2       C(CH.sub.3).sub.2 OCH.sub.3                         3.0826                                                                               H     CN             C(CH.sub.3).sub.2 OCH.sub.3                         3.0827                                                                               H     CH.sub.2 OH    C(CH.sub.3).sub.2 OCH.sub.3                         3.0828                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          C(CH.sub.3).sub.2 OCH.sub.3                         3.0829                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 C(CH.sub.3).sub.2 OCH.sub.3                         3.0830                                                                               H     C.sub.6 H.sub.5                                                                               C(CH.sub.3).sub.2 OCH.sub.3                         3.0831                                                                               H     CH.sub.2 Cl    C(CH.sub.3).sub.2 OCH.sub.3                         3.0832                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          C(CH.sub.3).sub.2 OCH.sub.3                         3.0833                                                                               H     CH.sub.2 CH.sub. 2 CH.sub.2 Cl                                                                C(CH.sub.3).sub.2 OCH.sub.3                         ______________________________________                                    

                  TABLE 3.09                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         3.0901                                                                               H     H              CH.sub.2 OC.sub.3 H.sub.7                           3.0902                                                                               H     CH.sub.3       CH.sub.2 OC.sub.3 H.sub.7                           3.0903                                                                               H     C.sub.2 H.sub.5                                                                               CH.sub.2 OC.sub.3 H.sub.7                           3.0904                                                                               H     C.sub.3 H.sub.7                                                                               CH.sub.2 OC.sub.3 H.sub.7                           3.0905                                                                               H     OCH.sub.3      CH.sub.2 OC.sub.3 H.sub.7                           3.0906                                                                               H     OC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.3 H.sub.7                           3.0907                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    CH.sub.2 OC.sub.3 H.sub.7                           3.0908                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  CH.sub.2 OC.sub.3 H.sub.7                           3.0909                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 CH.sub.2 OC.sub.3 H.sub.7                           3.0910                                                                               H     OCH.sub.2 CH═ CHCl                                                                        CH.sub.2 OC.sub.3 H.sub.7                           3.0911                                                                               H     OCH.sub.2 C.tbd. CH                                                                           CH.sub.2 OC.sub.3 H.sub.7                           3.0912                                                                               H     OCHF.sub.2     CH.sub.2 OC.sub.3 H.sub.7                           3.0913                                                                               H     OCF.sub.3      CH.sub.2 OC.sub.3 H.sub.7                           3.0914                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         CH.sub.2 OC.sub.3 H.sub.7                           3.0915                                                                               H     OC.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub. 3 H.sub.7                          3.0916                                                                               H     CF.sub.3       CH.sub.2 OC.sub.3 H.sub.7                           3.0917                                                                               H     Br             CH.sub.2 OC.sub.3 H.sub.7                           3.0918                                                                               H     Cl             CH.sub.2 OC.sub.3 H.sub.7                           3.0919                                                                               H     F              CH.sub.2 OC.sub.3 H.sub.7                           3.0920                                                                               H     SCH.sub.3      CH.sub.2 OC.sub.3 H.sub.7                           3.0921                                                                               H     SC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.3 H.sub.7                           3.0922                                                                               H     SC.sub.3 H.sub.7 -n                                                                           CH.sub.2 OC.sub.3 H.sub.7                           3.0923                                                                               H     SO.sub.2 CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                           3.0924                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.2 OC.sub.3 H.sub.7                           3.0925                                                                               H     NO.sub.2       CH.sub.2 OC.sub.3 H.sub.7                           3.0926                                                                               H     CN             CH.sub.2 OC.sub.3 H.sub.7                           3.0927                                                                               H     CH.sub.2 OH    CH.sub.2 OC.sub.3 H.sub.7                           3.0928                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          CH.sub.2 OC.sub.3 H.sub.7                           3.0929                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 CH.sub.2 OC.sub.3 H.sub.7                           3.0930                                                                               H     C.sub.6 H.sub.5                                                                               CH.sub.2 OC.sub.3 H.sub.7                           3.0931                                                                               H     CH.sub.2 Cl    CH.sub.2 OC.sub.3 H.sub.7                           3.0932                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          CH.sub.2 OC.sub.3 H.sub.7                           3.0933                                                                               H     CH.sub.2 CH.sub. 2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.3 H.sub.7                           ______________________________________                                    

                  TABLE 3.10                                                       ______________________________________                                                                                phys.                                   No.   X     Y              Z           data                                    ______________________________________                                         3.1001                                                                               H     H              C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1002                                                                               H     CH.sub.3       C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1003                                                                               H     C.sub.2 H.sub.5                                                                               C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1004                                                                               H     C.sub.3 H.sub.7                                                                               C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1005                                                                               H     OCH.sub.3      C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1006                                                                               H     OC.sub.2 H.sub.5                                                                              C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1007                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1008                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1009                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1010                                                                               H     OCH.sub.2 CH═ CHCl                                                                        C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1011                                                                               H     OCH.sub.2 C.tbd. CH                                                                           C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1012                                                                               H     OCHF.sub.2     C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1013                                                                               H     OCF.sub.3      C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1014                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1015                                                                               H     OC.sub.6 H.sub.5                                                                              C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1016                                                                               H     CF.sub.3       C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1017                                                                               H     Br             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1018                                                                               H     Cl             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1019                                                                               H     F              C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1020                                                                               H     SCH.sub.3      C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1021                                                                               H     SC.sub.2 H.sub.5                                                                              C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1022                                                                               H     SC.sub.3 H.sub.7 -n                                                                           C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1023                                                                               H     SO.sub.2 CH.sub.3                                                                             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1024                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1025                                                                               H     NO.sub.2       C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1026                                                                               H     CN             C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1027                                                                               H     CH.sub.2 OH    C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1028                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1029                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1030                                                                               H     C.sub.6 H.sub.5                                                                               C(CH.sub.3 )C.sub.2 H.sub.4 (cyclo)                 3.1031                                                                               H     CH.sub.2 Cl    C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1032                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  3.1033                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                  ______________________________________                                    

                  TABLE 3.11                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         3.1101                                                                               H     H              CH.sub.2 OC.sub.6 H.sub.5                           3.1102                                                                               H     CH.sub.3       CH.sub.2 OC.sub.6 H.sub.5                           3.1103                                                                               H     C.sub.2 H.sub.5                                                                               CH.sub.2 OC.sub.6 H.sub.5                           3.1104                                                                               H     C.sub.3 H.sub.7                                                                               CH.sub.2 OC.sub.6 H.sub.5                           3.1105                                                                               H     OCH.sub.3      CH.sub.2 OC.sub.6 H.sub.5                           3.1106                                                                               H     OC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.6 H.sub.5                           3.1107                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    CH.sub.2 OC.sub.6 H.sub.5                           3.1108                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  CH.sub.2 OC.sub.6 H.sub.5                           3.1109                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 CH.sub.2 OC.sub.6 H.sub.5                           3.1110                                                                               H     OCH.sub.2 CH═ CHCl                                                                        CH.sub.2 OC.sub.6 H.sub.5                           3.1111                                                                               H     OCH.sub.2 C.tbd. CH                                                                           CH.sub.2 OC.sub.6 H.sub.5                           3.1112                                                                               H     OCHF.sub.2     CH.sub.2 OC.sub.6 H.sub.5                           3.1113                                                                               H     OCF.sub.3      CH.sub.2 OC.sub.6 H.sub.5                           3.1114                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         CH.sub.2 OC.sub.6 H.sub.5                           3.1115                                                                               H     OC.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub. 6 H.sub.5                          3.1116                                                                               H     CF.sub.3       CH.sub.2 OC.sub.6 H.sub.5                           3.1117                                                                               H     Br             CH.sub.2 OC.sub.6 H.sub.5                           3.1118                                                                               H     Cl             CH.sub.2 OC.sub.6 H.sub.5                           3.1119                                                                               H     F              CH.sub.2 OC.sub.6 H.sub.5                           3.1120                                                                               H     SCH.sub.3      CH.sub.2 OC.sub.6 H.sub.5                           3.1121                                                                               H     SC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.6 H.sub.5                           3.1122                                                                               H     SC.sub.3 H.sub.7 -n                                                                           CH.sub.2 OC.sub.6 H.sub.5                           3.1123                                                                               H     SO.sub.2 CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                           3.1124                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.2 OC.sub.6 H.sub.5                           3.1125                                                                               H     NO.sub.2       CH.sub.2 OC.sub.6 H.sub.5                           3.1126                                                                               H     CN             CH.sub.2 OC.sub.6 H.sub.5                           3.1127                                                                               H     CH.sub.2 OH    CH.sub.2 OC.sub.6 H.sub.5                           3.1128                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          CH.sub.2 OC.sub.6 H.sub.5                           3.1129                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 CH.sub.2 OC.sub.6 H.sub.5                           3.1130                                                                               H     C.sub.6 H.sub.5                                                                               CH.sub.2 OC.sub.6 H.sub.5                           3.1131                                                                               H     CH.sub.2 Cl    CH.sub.2 OC.sub.6 H.sub.5                           3.1132                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          CH.sub.2 OC.sub.6 H.sub.5                           3.1133                                                                               H     CH.sub.2 CH.sub. 2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.6 H.sub.5                           ______________________________________                                    

                  TABLE 3.12                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         3.1201                                                                               H     H              furan-2-yl                                          3.1202                                                                               H     CH.sub.3       furan-2-yl                                          3.1203                                                                               H     C.sub.2 H.sub.5                                                                               furan-2-yl                                          3.1204                                                                               H     C.sub.3 H.sub.7                                                                               furan-2-yl                                          3.1205                                                                               H     OCH.sub.3      furan-2-yl                                          3.1206                                                                               H     OC.sub.2 H.sub.5                                                                              furan-2-yl                                          3.1207                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    furan-2-yl                                          3.1208                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  furan-2-yl                                          3.1209                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 furan-2-yl                                          3.1210                                                                               H     OCH.sub.2 CH═ CHCl                                                                        furan-2-yl                                          3.1211                                                                               H     OCH.sub.2 C.tbd. CH                                                                           furan-2-yl                                          3.1212                                                                               H     OCHF.sub.2     furan-2-yl                                          3.1213                                                                               H     OCF.sub.3      furan-2-yl                                          3.1214                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         furan-2-yl                                          3.1215                                                                               H     OC.sub.6 H.sub.5                                                                              furan-2-yl                                          3.1216                                                                               H     CF.sub.3       furan-2-yl                                          3.1217                                                                               H     Br             furan-2-yl                                          3.1218                                                                               H     Cl             furan-2-yl                                          3.1219                                                                               H     F              furan-2-yl                                          3.1220                                                                               H     SCH.sub.3      furan-2-yl                                          3.1221                                                                               H     SC.sub.2 H.sub.5                                                                              furan-2-yl                                          3.1222                                                                               H     SC.sub.3 H.sub.7 -n                                                                           furan-2-yl                                          3.1223                                                                               H     SO.sub.2 CH.sub.3                                                                             furan-2-yl                                          3.1224                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      furan-2-yl                                          3.1225                                                                               H     NO.sub.2       furan-2-yl                                          3.1226                                                                               H     CN             furan-2-yl                                          3.1227                                                                               H     CH.sub.2 OH    furan-2-yl                                          3.1228                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          furan-2-yl                                          3.1229                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 furan-2-yl                                          3.1230                                                                               H     C.sub.6 H.sub.5                                                                               furan-2-yl                                          3.1231                                                                               H     CH.sub.2 Cl    furan-2-yl                                          3.1232                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          furan-2-yl                                          3.1233                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 furan-2-yl                                          ______________________________________                                    

                  TABLE 3.13                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         3.1301                                                                               H     H              dioxan-2-yl                                         3.1302                                                                               H     CH.sub.3       dioxan-2-yl                                         3.1303                                                                               H     C.sub.2 H.sub.5                                                                               dioxan-2-yl                                         3.1304                                                                               H     C.sub.3 H.sub.7                                                                               dioxan-2-yl                                         3.1305                                                                               H     OCH.sub.3      dioxan-2-yl                                         3.1306                                                                               H     OC.sub.2 H.sub.5                                                                              dioxan-2-yl                                         3.1307                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                    dioxan-2-yl                                         3.1308                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                  dioxan-2-yl                                         3.1309                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                 dioxan-2-yl                                         3.1310                                                                               H     OCH.sub.2 CH═ CHCl                                                                        dioxan-2-yl                                         3.1311                                                                               H     OCH.sub.2 C.tbd. CH                                                                           dioxan-2-yl                                         3.1312                                                                               H     OCHF.sub.2     dioxan-2-yl                                         3.1313                                                                               H     OCF.sub.3      dioxan-2-yl                                         3.1314                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         dioxan-2-yl                                         3.1315                                                                               H     OC.sub.6 H.sub.5                                                                              dioxan-2-yl                                         3.1316                                                                               H     CF.sub.3       dioxan-2-yl                                         3.1317                                                                               H     Br             dioxan-2-yl                                         3.1318                                                                               H     Cl             dioxan-2-yl                                         3.1319                                                                               H     F              dioxan-2-yl                                         3.1320                                                                               H     SCH.sub.3      dioxan-2-yl                                         3.1321                                                                               H     SC.sub.2 H.sub.5                                                                              dioxan-2-yl                                         3.1322                                                                               H     SC.sub.3 H.sub.7 -n                                                                           dioxan-2-yl                                         3.1323                                                                               H     SO.sub.2 CH.sub.3                                                                             dioxan-2-yl                                         3.1324                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      dioxan-2-yl                                         3.1325                                                                               H     NO.sub.2       dioxan-2-yl                                         3.1326                                                                               H     CN             dioxan-2-yl                                         3.1327                                                                               H     CH.sub.2 OH    dioxan-2-yl                                         3.1328                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          dioxan-2-yl                                         3.1329                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 dioxan-2-yl                                         3.1330                                                                               H     C.sub.6 H.sub.5                                                                               dioxan-2-yl                                         3.1331                                                                               H     CH.sub.2 Cl    dioxan-2-yl                                         3.1332                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          dioxan-2-yl                                         3.1333                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 dioxan-2-yl                                         ______________________________________                                    

                  TABLE 3.14                                                       ______________________________________                                                                                phys.                                   No.   X      Y              Z          data                                    ______________________________________                                         3.1401                                                                               H      H              CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1402                                                                               H      CH.sub.3       CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1403                                                                               H      C.sub.2 H.sub.5                                                                               CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1404                                                                               H      C.sub.3 H.sub.7                                                                               CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1405                                                                               H      OCH.sub.3      CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1406                                                                               H      OC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1407                                                                               H      OCH.sub.2 CH═ CH.sub.2                                                                    CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1408                                                                               H      OCH.sub.2 CH═ CHCH.sub.3                                                                  CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1409                                                                               H      OCH.sub.2 C(Cl)═ CH.sub.2                                                                 CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1410                                                                               H      OCH.sub.2 CH═ CHCl                                                                        CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1411                                                                               H      OCH.sub.2 C.tbd. CH                                                                           CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1412                                                                               H      OCHF.sub.2     CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1413                                                                               H      OCF.sub. 3     CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1414                                                                               H      OCF.sub.2 CHFCF.sub.3                                                                         CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1415                                                                               H      OC.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1416                                                                               H      CF.sub.3       CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1417                                                                               H      Br             CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1418                                                                               H      Cl             CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1419                                                                               H      F              CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1420                                                                               H      SCH.sub.3      CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1421                                                                               H      SC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1422                                                                               H      SC.sub.3 H.sub.7 -n                                                                           CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1423                                                                               H      SO.sub.2 CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1424                                                                               H      SO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1425                                                                               H      NO.sub.2       CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1426                                                                               H      CN             CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1427                                                                               H      CH.sub.2 OH    CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1428                                                                               H      CH.sub.2 CH.sub.2 OH                                                                          CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1429                                                                               H      CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1430                                                                               H      C.sub.6 H.sub.5                                                                               CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1431                                                                               H      CH.sub.2 Cl    CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1432                                                                               H      CH.sub.2 CH.sub.2 Cl                                                                          CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                3.1433                                                                               H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3                ______________________________________                                    

                  TABLE 3.15                                                       ______________________________________                                                                                 phys.                                  No.   X     Y             Z             data                                   ______________________________________                                         3.1501                                                                               H     H             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1502                                                                               H     CH.sub.3      CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1503                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1504                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1505                                                                               H     OCH.sub.3     CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1506                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1507                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1508                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1509                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1510                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.2 OC.sub.2 H.sub.4 OC.sub. 2 H.sub.4                                    OCH.sub.3                                            3.1511                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1512                                                                               H     OCHF.sub.2    CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1513                                                                               H     OCF.sub.3     CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1514                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1515                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1516                                                                               H     CF.sub.3      CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1517                                                                               H     Br            CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1518                                                                               H     Cl            CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1519                                                                               H     F             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1520                                                                               H     SCH.sub.3     CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1521                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1522                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OC.sub.2 H.sub. 4 OC.sub.2 H.sub.4                                    OCH.sub.3                                            3.1523                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1524                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1525                                                                               H     NO.sub.2      CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1526                                                                               H     CN            CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1527                                                                               H     CH.sub.2 OH   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1528                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1529                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1530                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1531                                                                               H     CH.sub.2 Cl   CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1532                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            3.1533                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4                                     OCH.sub.3                                            ______________________________________                                    

                  TABLE 3.16                                                       ______________________________________                                                                                phys.                                   No.   X     Y             Z            data                                    ______________________________________                                         3.1601                                                                               H     H             CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1602                                                                               H     CH.sub.3      CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1603                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1604                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1605                                                                               H     OCH.sub.3     CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1606                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1607                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1608                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1609                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1610                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1611                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1612                                                                               H     OCHF.sub.2    CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1613                                                                               H     OCF.sub.3     CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1614                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1615                                                                               H     OC.sub.6 H.sub. 5                                                                            CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1616                                                                               H     CF.sub.3      CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1617                                                                               H     Br            CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1618                                                                               H     Cl            CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1619                                                                               H     F             CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1620                                                                               H     SCH.sub.3     CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1621                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1622                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1623                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1624                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1625                                                                               H     NO.sub.2      CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1626                                                                               H     CN            CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1627                                                                               H     CH.sub.2 OH   CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1628                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1629                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1630                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1631                                                                               H     CH.sub.2 Cl   CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1632                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OCH.sub.2 CONH.sub.2                        3.1633                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OCH.sub.2 CONH.sub.2                        ______________________________________                                    

EXAMPLE 11 Preparation of 5-ethyl-2-(5-isopropyl-5-methyl-4-oxo-imidazolin-2-yl)-6-methoxymethylpyridine-3-carboxylic acid methyl ester ##STR49##

3.4 g of 7-ethyl-8-methoxymethyl-2-isopropyl-2-methyl-2H-imidazo[1,2:1',2']pyrrolo[3,4-b]pyridine-3,5-dione are added at room temperature to a mixture of 0.37 g of methanol and 60 g of triethylamine in 30 ml of methylene chloride while stirring. When a homogeneous solution has been obtained this solution is left to stand for 2 days at room temperature. It is then concentrated by evaporation and the residue is chromatographed over a column of silica gel using ether. After evaporation of the ether 2.8 g of crystalline title substance having a melting point of 87°-90° C. remain.

The esters of Tables 4.00 to 4.016 of formula I are prepared analogously to Example 11 ##STR50##

                  TABLE 4.00                                                       ______________________________________                                                                                 phys.                                  No.   X     Y             R.sub.1                                                                             Z        data                                   ______________________________________                                         4.0001                                                                               H     H             CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0002                                                                               H     CH.sub.3      CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                                                                 m.p. 184-                                                                      187° C.                         4.0003                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                                                                 m.p. 167-                                                                      168° C.                         4.0004                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0005                                                                               H     OCH.sub.3     CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0006                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0007                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0008                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0009                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0010                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0011                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0012                                                                               H     OCHF.sub.2    CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0013                                                                               H     OCF.sub.3     CH.sub. 3                                                                           C.sub.3 H.sub.5 (cyclo)                         4.0014                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0015                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0016                                                                               H     CF.sub.3      CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0017                                                                               H     Br            CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0018                                                                               H     Cl            CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0019                                                                               H     F             CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0020                                                                               H     SCH.sub.3     CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0021                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0022                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0023                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0024                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0025                                                                               H     NO.sub.2      CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0026                                                                               H     CN            CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0027                                                                               H     CH.sub.2 OH   CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0028                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0029                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                            C.sub.3 H.sub. 5 (cyclo)                        4.0030                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0031                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0032                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         4.0033                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                         ______________________________________                                    

                  TABLE 4.01                                                       ______________________________________                                                                                  phys.                                 No.   X     Y             R.sub.1                                                                             Z         data                                  ______________________________________                                         4.0101                                                                               H     H             C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0102                                                                               H     CH.sub.3      C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0103                                                                               H     C.sub.2 H.sub.5                                                                              C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0140                                                                               H     C.sub.3 H.sub.7                                                                              C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0105                                                                               H     OCH.sub.3     C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0106                                                                               H     OC.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0107                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0108                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0109                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0110                                                                               H     OCH.sub.2 CH═ CHCl                                                                       C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0111                                                                               H     OCH.sub.2 C.tbd. CH                                                                          C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0112                                                                               H     OCHF.sub.2    C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0113                                                                               H     OCF.sub.3     C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0114                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0115                                                                               H     OC.sub.6 H.sub.5                                                                             C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0116                                                                               H     CF.sub.3      C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0117                                                                               H     Br            C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0118                                                                               H     Cl            C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0119                                                                               H     F             C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0120                                                                               H     SCH.sub.3     C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0121                                                                               H     SC.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0122                                                                               H     SC.sub.3 H.sub.7 -n                                                                          C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0123                                                                               H     SO.sub.2 CH.sub.3                                                                            C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0124                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0125                                                                               H     NO.sub.2      C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0126                                                                               H     CN            C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0127                                                                               H     CH.sub.2 OH   C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0128                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0129                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0130                                                                               H     C.sub.6 H.sub.5                                                                              C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0131                                                                               H     CH.sub.2 Cl   C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0132                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         4.0133                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                C.sub.2 H.sub.5                                                                     C.sub.4 H.sub.7 (cyclo)                         ______________________________________                                    

                  TABLE 4.02                                                       ______________________________________                                                                                  phys.                                 No.   X     Y             R.sub.1                                                                             Z         data                                  ______________________________________                                         4.0201                                                                               H     H             CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0202                                                                               H     CH.sub.3      CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0203                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0204                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0205                                                                               H     OCH.sub.3     CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0206                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0207                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0208                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0209                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0210                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0211                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0212                                                                               H     OCHF.sub.2    CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0213                                                                               H     OCF.sub.3     CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0214                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0215                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0216                                                                               H     CF.sub.3      CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0217                                                                               H     Br            CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0218                                                                               H     Cl            CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0219                                                                               H     F             CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0220                                                                               H     SCH.sub.3     CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0221                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0222                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0223                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0224                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0225                                                                               H     NO.sub.2      CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0226                                                                               H     CN            CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0227                                                                               H     CH.sub.2 OH   CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0228                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0229                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0230                                                                               H     C.sub. 6 H.sub.5                                                                             CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0231                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0232                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         4.0233                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                            C.sub.5 H.sub.9 (cyclo)                         ______________________________________                                    

                  TABLE 4.03                                                       ______________________________________                                                                                  phys.                                 No.   X     Y             R.sub.1                                                                             Z         data                                  ______________________________________                                         4.0301                                                                               H     H             CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0302                                                                               H     CH.sub.3      CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0303                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0304                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0305                                                                               H     OCH.sub.3     CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0306                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0307                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0308                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0309                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0310                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0311                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0312                                                                               H     OCHF.sub.2    CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0313                                                                               H     OCF.sub.3     CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0314                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0315                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0316                                                                               H     CF.sub.3      CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0317                                                                               H     Br            CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0318                                                                               H     Cl            CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0319                                                                               H     F             CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0320                                                                               H     SCH.sub.3     CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0321                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0322                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0323                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0324                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0325                                                                               H     NO.sub.2      CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0326                                                                               H     CN            CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0327                                                                               H     CH.sub.2 OH   CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0328                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0329                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0330                                                                               H     C.sub. 6 H.sub.5                                                                             CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0331                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0332                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        4.0333                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                            C.sub.6 H.sub.11 (cyclo)                        ______________________________________                                    

                  TABLE 4.04                                                       ______________________________________                                         No.   X     Y             R.sub.1                                                                             Z       phys. data                              ______________________________________                                         4.0401                                                                               H     H             CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0402                                                                               H     CH.sub.3      CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0403                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     m.p. 87-                                                                       90° C.                           4.0404                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0405                                                                               H     OCH.sub.3     CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0406                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0407                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0408                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0409                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0410                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0411                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0412                                                                               H     OCHF.sub.2    CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0413                                                                               H     OCF.sub.3     CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0414                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0415                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0416                                                                               H     CF.sub.3      CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0417                                                                               H     Br            CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0418                                                                               H     Cl            CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0419                                                                               H     F             CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0420                                                                               H     SCH.sub.3     CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0421                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0422                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0423                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0424                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0425                                                                               H     NO.sub.2      CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0426                                                                               H     CN            CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0427                                                                               H     CH.sub.2 OH   CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0428                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0429                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0430                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0431                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0432                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              4.0433                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                            CH.sub.2 OCH.sub.3                              ______________________________________                                    

                  TABLE 4.05                                                       ______________________________________                                                                                  phys.                                 No.   X     Y             R.sub.1                                                                             Z         data                                  ______________________________________                                         4.0501                                                                               H     H             CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0502                                                                               H     CH.sub.3      CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0503                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0504                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0505                                                                               H     OCH.sub.3     CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0506                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0507                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0508                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0509                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0510                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0511                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0512                                                                               H     OCHF.sub.2    CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0513                                                                               H     OCF.sub.3     CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0514                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0515                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0516                                                                               H     CF.sub.3      CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0517                                                                               H     Br            CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0518                                                                               H     Cl            CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0519                                                                               H     F             CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0520                                                                               H     SCH.sub.3     CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0521                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0522                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0523                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0524                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0525                                                                               H     NO.sub.2      CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0526                                                                               H     CN            CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0527                                                                               H     CH.sub.2 OH   CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0528                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0529                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0530                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0531                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           4.0532                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            CH(CH.sub. 3)OCH.sub.3                          4.0533                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                            CH(CH.sub.3)OCH.sub.3                           ______________________________________                                    

                  TABLE 4.06                                                       ______________________________________                                                                                  phys.                                 No.   X     Y             R.sub.1                                                                              Z        data                                  ______________________________________                                         4.0601                                                                               H     H             CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0602                                                                               H     CH.sub.3      CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0603                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0604                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0605                                                                               H     OCH.sub.3     CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0606                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0607                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0608                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0609                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0610                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0611                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0612                                                                               H     OCHF.sub.2    CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0613                                                                               H     OCF.sub.3     CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0614                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0615                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0616                                                                               H     CF.sub.3      CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0617                                                                               H     Br            CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0618                                                                               H     Cl            CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0619                                                                               H     F             CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0620                                                                               H     SCH.sub.3     CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0621                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0622                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0623                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0624                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0625                                                                               H     NO.sub.2      CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0626                                                                               H     CN            CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0627                                                                               H     CH.sub.2 OH   CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0628                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0629                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0630                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0631                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0632                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      4.0633                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                      ______________________________________                                    

                  TABLE 4.07                                                       ______________________________________                                                                                   phys.                                No.   X     Y             R.sub.1                                                                             Z          data                                 ______________________________________                                         4.0701                                                                               H     H             CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0702                                                                               H     CH.sub.3      CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0703                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0704                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0705                                                                               H     OCH.sub.3     CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0706                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0707                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0708                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0709                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0710                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0711                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0712                                                                               H     OCHF.sub.2    CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0713                                                                               H     OCF.sub. 3    CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0714                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0715                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0716                                                                               H     CF.sub.3      CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0717                                                                               H     Br            CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0718                                                                               H     Cl            CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0719                                                                               H     F             CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0720                                                                               H     SCH.sub.3     CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0721                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0722                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0723                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0724                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0725                                                                               H     NO.sub.2      CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0726                                                                               H     CN            CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0727                                                                               H     CH.sub.2 OH   CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0728                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                            CH(CH.sub.3 )OC.sub.2 H.sub.5                   4.0729                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0730                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0731                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0732                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    4.0733                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                            CH(CH.sub.3)OC.sub.2 H.sub.5                    ______________________________________                                    

                  TABLE 4.08                                                       ______________________________________                                                                                  phys.                                 No.   X     Y             R.sub.1                                                                             Z         data                                  ______________________________________                                         4.0801                                                                               H     H             CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0802                                                                               H     CH.sub.3      CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0803                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0804                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0805                                                                               H     OCH.sub.3     CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0806                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0807                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0808                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0809                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0810                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0811                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0812                                                                               H     OCHF.sub.2    CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0813                                                                               H     OCF.sub.3     CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0814                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0815                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0816                                                                               H     CF.sub.3      CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0817                                                                               H     Br            CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0818                                                                               H     Cl            CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0819                                                                               H     F             CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0820                                                                               H     SCH.sub.3     CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0821                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0822                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0823                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0824                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0825                                                                               H     NO.sub.2      CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0826                                                                               H     CN            CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0827                                                                               H     CH.sub.2 OH   CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0828                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0829                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0830                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0831                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0832                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     4.0833                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                            C(CH.sub.3).sub.2 OCH.sub.3                     ______________________________________                                    

                  TABLE 4.09                                                       ______________________________________                                                                                  phys.                                 No.   X     Y             R.sub.1                                                                              Z        data                                  ______________________________________                                         4.0901                                                                               H     H             CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0902                                                                               H     CH.sub.3      CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0903                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0904                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0905                                                                               H     OCH.sub.3     CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0906                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0907                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0908                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0909                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0910                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0911                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0912                                                                               H     OCHF.sub.2    CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0913                                                                               H     OCF.sub.3     CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0914                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0915                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0916                                                                               H     CF.sub.3      CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0917                                                                               H     Br            CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0918                                                                               H     Cl            CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0919                                                                               H     F             CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0920                                                                               H     SCH.sub.3     CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0921                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0922                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0923                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0924                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0925                                                                               H     NO.sub.2      CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0926                                                                               H     CN            CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0927                                                                               H     CH.sub.2 OH   CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0928                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0929                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0930                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0931                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0932                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      4.0933                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                             CH.sub.2 OC.sub.3 H.sub.7                      ______________________________________                                    

                                      TABLE 4.10                                   __________________________________________________________________________     No. X Y          R.sub.1                                                                           Z         phys. data                                       __________________________________________________________________________     4.1001                                                                             H H          CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                                                       m.p. 160-161° C.                          4.1002                                                                             H CH.sub.3   CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1003                                                                             H C.sub.2 H.sub.5                                                                           CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1004                                                                             H C.sub.3 H.sub.7                                                                           CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1005                                                                             H OCH.sub.3  CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1006                                                                             H OC.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1007                                                                             H OCH.sub.2 CH═ CH.sub.2                                                                CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1008                                                                             H OCH.sub.2 CH═ CHCH.sub.3                                                              CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1009                                                                             H OCH.sub.2 C(Cl)═ CH.sub.2                                                             CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1010                                                                             H OCH.sub.2 CH═ CHCl                                                                    CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1011                                                                             H OCH.sub.2 C.tbd. CH                                                                       CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1012                                                                             H OCHF.sub.2 CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1013                                                                             H OCF.sub.3  CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1014                                                                             H OCF.sub.2 CHFCF.sub.3                                                                     CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1015                                                                             H OC.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1016                                                                             H CF.sub.3   CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1017                                                                             H Br         CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1018                                                                             H Cl         CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1019                                                                             H F          CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1020                                                                             H SCH.sub.3  CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1021                                                                             H SC.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1022                                                                             H SC.sub.3 H.sub.7 -n                                                                       CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1023                                                                             H SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1024                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                  CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1025                                                                             H NO.sub.2   CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1026                                                                             H CN         CH.sub.3                                                                          C(CH.sub. 3)C.sub.2 H.sub.4 (cyclo)                        4.1027                                                                             H CH.sub.2 OH                                                                               CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1028                                                                             H CH.sub.2 CH.sub.2 OH                                                                      CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1029                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                             CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1030                                                                             H C.sub.6 H.sub.5                                                                           CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1031                                                                             H CH.sub.2 Cl                                                                               CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1032                                                                             H CH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         4.1033                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                          C(CH.sub.3)C.sub.2 H.sub.4 (cyclo)                         __________________________________________________________________________

                  TABLE 4.11                                                       ______________________________________                                                                                  phys.                                 No.   X     Y             R.sub.1                                                                              Z        data                                  ______________________________________                                         4.1101                                                                               H     H             CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1102                                                                               H     CH.sub.3      CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1103                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1104                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1105                                                                               H     OCH.sub.3     CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1106                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1107                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1108                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1109                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1110                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1111                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1112                                                                               H     OCHF.sub.2    CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1113                                                                               H     OCF.sub.3     CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1114                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1115                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1116                                                                               H     CF.sub.3      CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1117                                                                               H     Br            CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1118                                                                               H     Cl            CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1119                                                                               H     F             CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1120                                                                               H     SCH.sub.3     CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1121                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1122                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1123                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1124                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1125                                                                               H     NO.sub.2      CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1126                                                                               H     CN            CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1127                                                                               H     CH.sub.2 OH   CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1128                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1129                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1130                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1131                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1132                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      4.1133                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                      ______________________________________                                    

                  TABLE 4.12                                                       ______________________________________                                                                                 phys.                                  No.   X     Y             R.sub.1                                                                              Z       data                                   ______________________________________                                         4.1201                                                                               H     H             CH.sub.3                                                                             furan-2-yl                                     4.1202                                                                               H     CH.sub.3      CH.sub.3                                                                             furan-2-yl                                     4.1203                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                             furan-2-yl                                     4.1204                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                             furan-2-yl                                     4.1205                                                                               H     OCH.sub.3     CH.sub.3                                                                             furan-2-yl                                     4.1206                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                             furan-2-yl                                     4.1207                                                                               H     OCH.sub.2 CH═ CH.sub.2                                                                   CH.sub.3                                                                             furan-2-yl                                     4.1208                                                                               H     OCH.sub.2 CH═ CHCH.sub.3                                                                 CH.sub.3                                                                             furan-2-yl                                     4.1209                                                                               H     OCH.sub.2 C(Cl)═ CH.sub.2                                                                CH.sub.3                                                                             furan-2-yl                                     4.1210                                                                               H     OCH.sub.2 CH═ CHCl                                                                       CH.sub.3                                                                             furan-2-yl                                     4.1211                                                                               H     OCH.sub.2 C.tbd. CH                                                                          CH.sub.3                                                                             furan-2-yl                                     4.1212                                                                               H     OCHF.sub.2    CH.sub.3                                                                             furan-2-yl                                     4.1213                                                                               H     OCF.sub.3     CH.sub.3                                                                             furan-2-yl                                     4.1214                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                             furan-2-yl                                     4.1215                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                             furan-2-yl                                     4.1216                                                                               H     CF.sub.3      CH.sub.3                                                                             furan-2-yl                                     4.1217                                                                               H     Br            CH.sub.3                                                                             furan-2-yl                                     4.1218                                                                               H     Cl            CH.sub.3                                                                             furan-2-yl                                     4.1219                                                                               H     F             CH.sub.3                                                                             furan-2-yl                                     4.1220                                                                               H     SCH.sub.3     CH.sub.3                                                                             furan-2-yl                                     4.1221                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                             furan-2-yl                                     4.1222                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                             furan-2-yl                                     4.1223                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             furan-2-yl                                     4.1224                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                             furan-2-yl                                     4.1225                                                                               H     NO.sub.2      CH.sub.3                                                                             furan-2-yl                                     4.1226                                                                               H     CN            CH.sub.3                                                                             furan-2-yl                                     4.1227                                                                               H     CH.sub.2 OH   CH.sub.3                                                                             furan-2-yl                                     4.1228                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                             furan-2-yl                                     4.1229                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                             furan-2-yl                                     4.1230                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                             furan-2-yl                                     4.1231                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                             furan-2-yl                                     4.1232                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             furan-2-yl                                     4.1233                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                             furan-2-yl                                     ______________________________________                                    

                  TABLE 4.13                                                       ______________________________________                                         No.   X     Y             R.sub.1                                                                             Z       phys. data                              ______________________________________                                         4.1301                                                                               H     H             CH.sub.3                                                                            dioxan-2-yl                                     4.1302                                                                               H     CH.sub.3      CH.sub.3                                                                            dioxan-2-yl                                     4.1303                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                            dioxan-2-yl                                     4.1304                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                            dioxan-2-yl                                     4.1305                                                                               H     OCH.sub.3     CH.sub.3                                                                            dioxan-2-yl                                     4.1306                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            dioxan-2-yl                                     4.1307                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH.sub.3                                                                            dioxan-2-yl                                     4.1308                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH.sub.3                                                                            dioxan-2-yl                                     4.1309                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 CH.sub.3                                                                            dioxan-2-yl                                     4.1310                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH.sub.3                                                                            dioxan-2-yl                                     4.1311                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH.sub.3                                                                            dioxan-2-yl                                     4.1312                                                                               H     OCHF.sub.2    CH.sub.3                                                                            dioxan-2-yl                                     4.1313                                                                               H     OCF.sub.3     CH.sub.3                                                                            dioxan-2-yl                                     4.1314                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                            dioxan-2-yl                                     4.1315                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                            dioxan-2-yl                                     4.1316                                                                               H     CF.sub.3      CH.sub.3                                                                            dioxan-2-yl                                     4.1317                                                                               H     Br            CH.sub.3                                                                            dioxan-2-yl                                     4.1318                                                                               H     Cl            CH.sub.3                                                                            dioxan-2-yl                                     4.1319                                                                               H     F             CH.sub.3                                                                            dioxan-2-yl                                     4.1320                                                                               H     SCH.sub.3     CH.sub.3                                                                            dioxan-2-yl                                     4.1321                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            dioxan-2-yl                                     4.1322                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                            dioxan-2-yl                                     4.1323                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            dioxan-2-yl                                     4.1324                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                            dioxan-2-yl                                     4.1325                                                                               H     NO.sub.2      CH.sub.3                                                                            dioxan-2-yl                                     4.1326                                                                               H     CN            CH.sub.3                                                                            dioxan-2-yl                                     4.1327                                                                               H     CH.sub.2 OH   CH.sub.3                                                                            dioxan-2-yl                                     4.1328                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                            dioxan-2-yl                                     4.1329                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                            dioxan-2-yl                                     4.1330                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                            dioxan-2-yl                                     4.1331                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                            dioxan-2-yl                                     4.1332                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            dioxan-2-yl                                     4.1333                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                            dioxan-2-yl                                     ______________________________________                                    

                  TABLE 4.14                                                       ______________________________________                                                                                   phys.                                No.   X     Y             R.sub.1                                                                             Z          data                                 ______________________________________                                         4.1401                                                                               H     H             CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1402                                                                               H     CH.sub.3      CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1403                                                                               H     C.sub.2 H.sub.5                                                                              CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1404                                                                               H     C.sub.3 H.sub.7                                                                              CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1405                                                                               H     OCH.sub.3     CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1406                                                                               H     OC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1407                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1408                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1409                                                                               H     OCH.sub.2 C(Cl)l═CH.sub.2                                                                CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1410                                                                               H     OCH.sub.2 CH═CHCl                                                                        CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1411                                                                               H     OCH.sub.2 C.tbd.CH                                                                           CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1412                                                                               H     OCHF.sub.2    CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1413                                                                               H     OCF.sub.3     CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1414                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1415                                                                               H     OC.sub.6 H.sub.5                                                                             CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1416                                                                               H     CF.sub.3      CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1417                                                                               H     Br            CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1418                                                                               H     Cl            CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1419                                                                               H     F             CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1420                                                                               H     SCH.sub.3     CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1421                                                                               H     SC.sub.2 H.sub.5                                                                             CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1422                                                                               H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1423                                                                               H     SO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1424                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1425                                                                               H     NO.sub.2      CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1426                                                                               H     CN            CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1427                                                                               H     CH.sub.2 OH   CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1428                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1429                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1430                                                                               H     C.sub.6 H.sub.5                                                                              CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1431                                                                               H     CH.sub.2 Cl   CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1432                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             4.1433                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.4 OCH.sub.3             ______________________________________                                    

                                      TABLE 4.15                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           Z           phys. data                                      __________________________________________________________________________     4.1501                                                                             H H         CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1502                                                                             H CH.sub.3  CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1503                                                                             H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1504                                                                             H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1505                                                                             H OCH.sub.3 CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1506                                                                             H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1507                                                                             H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1508                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1509                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub. 3       4.1510                                                                             H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1511                                                                             H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1512                                                                             H OCHF.sub.2                                                                               CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1513                                                                             H OCF.sub.3 CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1514                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1515                                                                             H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1516                                                                             H CF.sub.3  CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1517                                                                             H Br        CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1518                                                                             H Cl        CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1519                                                                             H F         CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1520                                                                             H SCH.sub.3 CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1521                                                                             H SC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1522                                                                             H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1523                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1524                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1525                                                                             H NO.sub.2  CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1526                                                                             H CN        CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1527                                                                             H CH.sub.2 OH                                                                              CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1528                                                                             H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1529                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1530                                                                             H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub. 2 H.sub.4 OCH.sub.3       4.1531                                                                             H CH.sub.2 Cl                                                                              CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1532                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        4.1533                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          CH.sub.2 OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3        __________________________________________________________________________

                                      TABLE 4.16                                   __________________________________________________________________________     No. X Y         R.sub.1                                                                           Z          phys. data                                       __________________________________________________________________________     4.1601                                                                             H H         CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1602                                                                             H CH.sub.3  CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1603                                                                             H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1604                                                                             H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1605                                                                             H OCH.sub.3 CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1606                                                                             H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1607                                                                             H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1608                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1609                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1610                                                                             H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1611                                                                             H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1612                                                                             H OCHF.sub.2                                                                               CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1613                                                                             H OCF.sub.3 CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1614                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1615                                                                             H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1616                                                                             H CF.sub.3  CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1617                                                                             H Br        CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1618                                                                             H Cl        CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1619                                                                             H F         CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1620                                                                             H SCH.sub.3 CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1621                                                                             H SC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1622                                                                             H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1623                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1624                                                                             H SO.sub.2 C.sub.2 H.sub.5                                                                 CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1625                                                                             H NO.sub.2  CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1626                                                                             H CN        CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1627                                                                             H CH.sub.2 OH                                                                              CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1628                                                                             H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1629                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1630                                                                             H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1631                                                                             H CH.sub.2 Cl                                                                              CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1632                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               4.1633                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          CH.sub.2 OCH.sub.2 CONH.sub.2                               __________________________________________________________________________

EXAMPLE 12 Preparation of 6-ethoxymethylpyridine-2,3-dicarboxylic acid ##STR51##

37.4 g of 6-ethoxymethylpyridine-2,3-carboxylic acid diethyl ester are added to a solution of 0.5 g of tetrabutylammonium bromide in 140 ml of aqueous 15% sodium hydroxide solution while stirring. A slightly exothermic reaction is observed. The reaction mixture is then stirred for 3 hours at room temperature and subsequently extensively concentrated by evaporation, the disodium salt of 6-ethoxymethylpyridine-2,3-dicarboxylic acid being precipitated. 50 ml of water are added to the residue which is extracted with ether. 0.5 g of educt remain in the ether extract. The aqueous phase is acidified to pH 2 with concentrated hydrochloric acid and then extracted 5 times with 100 ml of ethyl acetate each time. The organic phases are collected, dried over magnesium sulphate and concentrated by evaporation. 26 g of the above acid are obtained in the form of a honey-yellow resinous substance.

EXAMPLE 13 Preparation of 6-phenoxymethylpyridine-2,3-dicarboxylic acid ##STR52##

42 g of 6-phenoxymethylpyridine-2,3-dicarboxylic acid diethyl ester are added to a solution of 0.5 g of tetrabutylammonium bromide in 140 ml of 15% aqueous sodium hydroxide solution while stirring. The resulting suspension is heated to 80° and stirred for one hour. The reaction mixture is then diluted with 300 ml of water and the solution is acidified to pH 2 using concentrated hydrochloric acid, during the course of which a precipitate forms which is filtered off with suction. The filtration residue is stirred with methylene chloride/tetrahydrofuran and filtered. The filtrate is dried over magnesium sulphate, concentrated and combined with the contents of the suction filter. After the whole has been dried again over phosphorus pentoxide, 34 g of the above acid, having a melting point of 270° with decomposition, are obtained.

The pyridine-2,3-dicarboxylic acids of formula VI listed in Tables 6.00 and 6.01 are prepared in a manner analogous to that described in Examples 12 and 13. ##STR53##

                  TABLE 6.00                                                       ______________________________________                                         No.   X     Y             Z         phys. data                                 ______________________________________                                         6.0001                                                                               H     H             C.sub.3 H.sub.5 (cyclo)                              6.0002                                                                               H     CH.sub.3      C.sub.3 H.sub.5 (cyclo)                              6.0003                                                                               H     C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.5 (cyclo)                              6.0004                                                                               H     C.sub.3 H.sub.7                                                                              C.sub.3 H.sub.5 (cyclo)                              6.0005                                                                               H     OCH.sub.3     C.sub.3 H.sub.5 (cyclo)                              6.0006                                                                               H     OC.sub.2 H.sub.5                                                                             C.sub.3 H.sub.5 (cyclo)                              6.0007                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    C.sub.3 H.sub.5 (cyclo)                              6.0008                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  C.sub.3 H.sub.5 (cyclo)                              6.0009                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 C.sub.3 H.sub.5 (cyclo)                              6.0010                                                                               H     OCH.sub.2 CH═CHCl                                                                        C.sub.3 H.sub.5 (cyclo)                              6.0011                                                                               H     OCH.sub.2 C.tbd.CH                                                                           C.sub.3 H.sub.5 (cyclo)                              6.0012                                                                               H     OCHF.sub.2    C.sub.3 H.sub.5 (cyclo)                              6.0013                                                                               H     OCF.sub.3     C.sub.3 H.sub.5 (cyclo)                              6.0014                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        C.sub.3 H.sub.5 (cyclo)                              6.0015                                                                               H     OC.sub.6 H.sub.5                                                                             C.sub.3 H.sub.5 (cyclo)                              6.0016                                                                               H     CF.sub.3      C.sub.3 H.sub.5 (cyclo)                              6.0017                                                                               H     Br            C.sub.3 H.sub.5 (cyclo)                              6.0018                                                                               H     Cl            C.sub.3 H.sub.5 (cyclo)                              6.0019                                                                               H     F             C.sub.3 H.sub.5 (cyclo)                              6.0020                                                                               H     SCH.sub.3     C.sub.3 H.sub.5 (cyclo)                              6.0021                                                                               H     SC.sub.2 H.sub.5                                                                             C.sub.3 H.sub.5 (cyclo)                              6.0022                                                                               H     SC.sub.3 H.sub.7 -n                                                                          C.sub.3 H.sub.5 (cyclo)                              6.0023                                                                               H     SO.sub.2 CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                              6.0024                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              6.0025                                                                               H     NO.sub.2      C.sub.3 H.sub.5 (cyclo)                              6.0026                                                                               H     CN            C.sub.3 H.sub.5 (cyclo)                              6.0027                                                                               H     CH.sub.2 OH   C.sub.3 H.sub.5 (cyclo)                              6.0028                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         C.sub.3 H.sub.5 (cyclo)                              6.0029                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                C.sub.3 H.sub.5 (cyclo)                              6.0030                                                                               H     C.sub.6 H.sub.5                                                                              C.sub.3 H.sub.5 (cyclo)                              6.0031                                                                               H     CH.sub.2 Cl   C.sub.3 H.sub.5 (cyclo)                              6.0032                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         C.sub.3 H.sub.5 (cyclo)                              6.0033                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                C.sub.3 H.sub.5 (cyclo)                              ______________________________________                                    

                  TABLE 6.01                                                       ______________________________________                                         No.    X     Y             Z        phys. data                                 ______________________________________                                         6.0101 H     H             CH.sub.2 OC.sub.2 H.sub.5                           6.0102 H     CH.sub.3      CH.sub.2 OC.sub.2 H.sub.5                           6.0103 H     C.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.5                           6.0104 H     C.sub.3 H.sub.7                                                                              CH.sub.2 OC.sub.2 H.sub.5                           6.0105 H     OCH.sub.3     CH.sub.2 OC.sub.2 H.sub.5                           6.0213 H     OCF.sub.3     CH.sub.2 OC.sub.2 H.sub.5                           6.0214 H     OCF.sub.2 CHFCF.sub.3                                                                        CH.sub.2 OC.sub.2 H.sub.5                           6.0215 H     OC.sub.6 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.5                           6.0216 H     CF.sub.3      CH.sub.2 OC.sub.2 H.sub.5                           6.0217 H     Br            CH.sub.2 OC.sub.2 H.sub.5                           6.0218 H     Cl            CH.sub.2 OC.sub.2 H.sub.5                           6.0219 H     F             CH.sub.2 OC.sub.2 H.sub.5                           6.0220 H     SCH.sub.3     CH.sub.2 OC.sub.2 H.sub.5                           6.0221 H     SC.sub.2 H.sub.5                                                                             CH.sub.2 OC.sub.2 H.sub.5                           6.0222 H     SC.sub.3 H.sub.7 -n                                                                          CH.sub.2 OC.sub.2 H.sub.5                           6.0223 H     SO.sub.2 CH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                           6.0224 H     SO.sub.2 C.sub.2 H.sub.5                                                                     CH.sub.2 OC.sub.2 H.sub.5                           6.0225 H     NO.sub.2      CH.sub.2 OC.sub.2 H.sub.5                           6.0226 H     CN            CH.sub.2 OC.sub.2 H.sub.5                           6.0227 H     CH.sub.2 OH   CH.sub.2 OC.sub.2 H.sub.5                           6.0228 H     CH.sub.2 CH.sub.2 OH                                                                         CH.sub.2 OC.sub.2 H.sub.5                           6.0229 H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                CH.sub.2 OC.sub.2 H.sub.5                           6.0230 H     C.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.5                           6.0231 H     CH.sub.2 Cl   CH.sub.2 OC.sub.2 H.sub.5                           6.0232 H     CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.2 OC.sub.2 H.sub.5                           6.0233 H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                CH.sub.2 OC.sub.2 H.sub.5                           ______________________________________                                    

EXAMPLE 14 Preparation of 6-ethoxymethylpyridine-2,3-dicarboxylic acid anhydride ##STR54##

21 g of 6-ethoxymethylpyridine-2,3-dicarboxylic acid are added to a mixture of 100 ml of dimethoxyethane, 28 ml of acetic anhydride and 15 ml of pyridine while stirring and the whole is further stirred for 6 hours at room temperature before being concentrated by evaporation under a high vacuum. 20 g of anhydride remain in the form of an oily liquid with a refractive index n_(D) ²² of 1.5480.

EXAMPLE 15 Preparation of 6-phenoxymethylpyridine-2,3-dicarboxylic acid anhydride ##STR55##

30 g of 6-phenoxymethylpyridine-2,3-dicarboxylic acid are added to a mixture of 100 ml of dimethoxyethane, 28 ml of acetic anhydride and 15 ml of pyridine while stirring and the reaction mixture is further stirred for one hour at room temperature. The whole is then concentrated by evaporation under a high vacuum. The above anhydride remains in the form of a light-coloured oil.

The pyridine-2,3-dicarboxylic acid anhydrides of formula VII listed in Tables 7.00 to 7.02 are prepared in a manner analogous to that described in Example 14 and 15. ##STR56##

                  TABLE 7.00                                                       ______________________________________                                         No.   X     Y             Z         phys. data                                 ______________________________________                                         7.0001                                                                               H     H             C.sub.3 H.sub.5 (cyclo)                              7.0002                                                                               H     CH.sub.3      C.sub.3 H.sub.5 (cyclo)                              7.0003                                                                               H     C.sub.2 H.sub.5                                                                              C.sub.3 H.sub.5 (cyclo)                              7.0004                                                                               H     C.sub.3 H.sub.7                                                                              C.sub.3 H.sub.5 (cyclo)                              7.0005                                                                               H     OCH.sub.3     C.sub.3 H.sub.5 (cyclo)                              7.0006                                                                               H     OC.sub.2 H.sub.5                                                                             C.sub.3 H.sub.5 (cyclo)                              7.0007                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                    C.sub.3 H.sub.5 (cyclo)                              7.0008                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                  C.sub.3 H.sub.5 (cyclo)                              7.0009                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                 C.sub.3 H.sub.5 (cyclo)                              7.0010                                                                               H     OCH.sub.2 CH═CHCl                                                                        C.sub.3 H.sub.5 (cyclo)                              7.0011                                                                               H     OCH.sub.2 C.tbd.CH                                                                           C.sub.3 H.sub.5 (cyclo)                              7.0012                                                                               H     OCHF.sub.2    C.sub.3 H.sub.5 (cyclo)                              7.0013                                                                               H     OCF.sub.3     C.sub.3 H.sub.5 (cyclo)                              7.0014                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                        C.sub.3 H.sub.5 (cyclo)                              7.0015                                                                               H     OC.sub.6 H.sub.5                                                                             C.sub.3 H.sub.5 (cyclo)                              7.0016                                                                               H     CF.sub.3      C.sub.3 H.sub.5 (cyclo)                              7.0017                                                                               H     Br            C.sub.3 H.sub.5 (cyclo)                              7.0018                                                                               H     Cl            C.sub. 3 H.sub.5 (cyclo)                             7.0019                                                                               H     F             C.sub.3 H.sub.5 (cyclo)                              7.0020                                                                               H     SCH.sub.3     C.sub.3 H.sub.5 (cyclo)                              7.0021                                                                               H     SC.sub.2 H.sub.5                                                                             C.sub.3 H.sub.5 (cyclo)                              7.0022                                                                               H     SC.sub.3 H.sub.7 -n                                                                          C.sub.3 H.sub.5 (cyclo)                              7.0023                                                                               H     SO.sub.2 CH.sub.3                                                                            C.sub.3 H.sub.5 (cyclo)                              7.0024                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                     C.sub.3 H.sub.5 (cyclo)                              7.0025                                                                               H     NO.sub.2      C.sub.3 H.sub.5 (cyclo)                              7.0026                                                                               H     CN            C.sub.3 H.sub.5 (cyclo)                              7.0027                                                                               H     CH.sub.2 OH   C.sub.3 H.sub.5 (cyclo)                              7.0028                                                                               H     CH.sub.2 CH.sub.2 OH                                                                         C.sub.3 H.sub.5 (cyclo)                              7.0029                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                C.sub.3 H.sub.5 (cyclo)                              7.0030                                                                               H     C.sub.6 H.sub.5                                                                              C.sub.3 H.sub.5 (cyclo)                              7.0031                                                                               H     CH.sub.2 Cl   C.sub.3 H.sub.5 (cyclo)                              7.0032                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                         C.sub.3 H.sub.5 (cyclo)                              7.0033                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                C.sub.3 H.sub.5 (cyclo)                              ______________________________________                                    

                  TABLE 7.01                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         7.0101                                                                               H     H              CH.sub.2 OC.sub.2 H.sub.5                           7.0102                                                                               H     CH.sub.3       CH.sub.2 OC.sub.2 H.sub.5                           7.0103                                                                               H     C.sub.2 H.sub.5                                                                               CH.sub.2 OC.sub.2 H.sub.5                           7.0104                                                                               H     C.sub.3 H.sub.7                                                                               CH.sub.2 OC.sub.2 H.sub.5                           7.0105                                                                               H     OCH.sub.3      CH.sub.2 OC.sub.2 H.sub.5                           7.0106                                                                               H     OC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.5                           7.0107                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                     CH.sub.2 OC.sub.2 H.sub.5                           7.0108                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                   CH.sub.2 OC.sub.2 H.sub.5                           7.0109                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                  CH.sub.2 OC.sub.2 H.sub.5                           7.0110                                                                               H     OCH.sub.2 CH═CHCl                                                                         CH.sub.2 OC.sub.2 H.sub.5                           7.0111                                                                               H     OCH.sub.2 C.tbd.CH                                                                            CH.sub.2 OC.sub.2 H.sub.5                           7.0112                                                                               H     OCHF.sub.2     CH.sub.2 OC.sub.2 H.sub.5                           7.0113                                                                               H     OCF.sub.3      CH.sub.2 OC.sub.2 H.sub.5                           7.0114                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         CH.sub.2 OC.sub.2 H.sub.5                           7.0115                                                                               H     OC.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.5                           7.0116                                                                               H     CF.sub.3       CH.sub.2 OC.sub. 2 H.sub.5                          7.0117                                                                               H     Br             CH.sub.2 OC.sub.2 H.sub.5                           7.0118                                                                               H     Cl             CH.sub.2 OC.sub.2 H.sub.5                           7.0119                                                                               H     F              CH.sub.2 OC.sub.2 H.sub.5                           7.0120                                                                               H     SCH.sub.3      CH.sub.2 OC.sub.2 H.sub.5                           7.0121                                                                               H     SC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.2 H.sub.5                           7.0122                                                                               H     SC.sub.3 H.sub.7 -n                                                                           CH.sub.2 OC.sub.2 H.sub.5                           7.0123                                                                               H     SO.sub.2 CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                           7.0124                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.2 OC.sub.2 H.sub.5                           7.0125                                                                               H     NO.sub.2       CH.sub.2 OC.sub.2 H.sub.5                           7.0126                                                                               H     CN             CH.sub.2 OC.sub.2 H.sub.5                           7.0127                                                                               H     CH.sub.2 OH    CH.sub.2 OC.sub.2 H.sub.5                           7.0128                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          CH.sub.2 OC.sub.2 H.sub.5                           7.0129                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 CH.sub.2 OC.sub.2 H.sub.5                           7.0130                                                                               H     C.sub.6 H.sub.5                                                                               CH.sub.2 OC.sub.2 H.sub.5                           7.0131                                                                               H     CH.sub.2 Cl    CH.sub.2 OC.sub.2 H.sub.5                           7.0132                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          CH.sub.2 OC.sub.2 H.sub.5                           7.0133                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 CH.sub.2 OC.sub.2 H.sub.5                           ______________________________________                                    

                  TABLE 7.02                                                       ______________________________________                                         No.   X     Y              Z        phys. data                                 ______________________________________                                         7.0201                                                                               H     H              CH.sub.2 OC.sub.6 H.sub.5                           7.0202                                                                               H     CH.sub.3       CH.sub.2 OC.sub.6 H.sub.5                           7.0203                                                                               H     C.sub.2 H.sub.5                                                                               CH.sub.2 OC.sub.6 H.sub.5                           7.0204                                                                               H     C.sub.3 H.sub.7                                                                               CH.sub.2 OC.sub.6 H.sub.5                           7.0205                                                                               H     OCH.sub.3      CH.sub.2 OC.sub.6 H.sub.5                           7.0206                                                                               H     OC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.6 H.sub.5                           7.0207                                                                               H     OCH.sub.2 CH═CH.sub.2                                                                     CH.sub.2 OC.sub.6 H.sub.5                           7.0208                                                                               H     OCH.sub.2 CH═CHCH.sub.3                                                                   CH.sub.2 OC.sub.6 H.sub.5                           7.0209                                                                               H     OCH.sub.2 C(Cl)═CH.sub.2                                                                  CH.sub.2 OC.sub.6 H.sub.5                           7.0210                                                                               H     OCH.sub.2 CH═CHCl                                                                         CH.sub.2 OC.sub.6 H.sub.5                           7.0211                                                                               H     OCH.sub.2 C.tbd.CH                                                                            CH.sub.2 OC.sub.6 H.sub.5                           7.0212                                                                               H     OCHF.sub.2     CH.sub.2 OC.sub.6 H.sub.5                           7.0213                                                                               H     OCF.sub.3      CH.sub.2 OC.sub.6 H.sub.5                           7.0214                                                                               H     OCF.sub.2 CHFCF.sub.3                                                                         CH.sub.2 OC.sub.6 H.sub.5                           7.0215                                                                               H     OC.sub.6 H.sub.5                                                                              CH.sub.2 OC.sub.6 H.sub.5                           7.0216                                                                               H     CF.sub.3       CH.sub.2 OC.sub. 6 H.sub.5                          7.0217                                                                               H     Br             CH.sub.2 OC.sub.6 H.sub.5                           7.0218                                                                               H     Cl             CH.sub.2 OC.sub.6 H.sub.5                           7.0219                                                                               H     F              CH.sub.2 OC.sub.6 H.sub.5                           7.0220                                                                               H     SCH.sub.3      CH.sub.2 OC.sub.6 H.sub.5                           7.0221                                                                               H     SC.sub.2 H.sub.5                                                                              CH.sub.2 OC.sub.6 H.sub.5                           7.0222                                                                               H     SC.sub.3 H.sub.7 -n                                                                           CH.sub.2 OC.sub.6 H.sub.5                           7.0223                                                                               H     SO.sub.2 CH.sub.3                                                                             CH.sub.2 OC.sub.6 H.sub.5                           7.0224                                                                               H     SO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.2 OC.sub.6 H.sub.5                           7.0225                                                                               H     NO.sub.2       CH.sub.2 OC.sub.6 H.sub.5                           7.0226                                                                               H     CN             CH.sub.2 OC.sub.6 H.sub.5                           7.0227                                                                               H     CH.sub.2 OH    CH.sub.2 OC.sub.6 H.sub.5                           7.0228                                                                               H     CH.sub.2 CH.sub.2 OH                                                                          CH.sub.2 OC.sub.6 H.sub.5                           7.0229                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 OH                                                                 CH.sub.2 OC.sub.6 H.sub.5                           7.0230                                                                               H     C.sub.6 H.sub.5                                                                               CH.sub.2 OC.sub.6 H.sub.5                           7.0231                                                                               H     CH.sub.2 Cl    CH.sub.2 OC.sub.6 H.sub.5                           7.0232                                                                               H     CH.sub.2 CH.sub.2 Cl                                                                          CH.sub.2 OC.sub.6 H.sub.5                           7.0233                                                                               H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 CH.sub.2 OC.sub.6 H.sub.5                           ______________________________________                                    

EXAMPLE 16 Preparation of 2-(N-2-methyl-valylamide)-carbamoyl-6-phenoxymethyl-nicotinic acid ##STR57##

13 g of 2-methyl-valinamide are added to a solution of 2.55 g of 6-phenoxymethylpyridine-2,3-dicarboxylic acid in 30 ml of tetrahydrofuran while stirring and the reaction mixture is further stirred for 14 hours at room temperature before being concentrated by evaporation. An oily residue remains, which is purified by crystallisation from ether/petroleum ether. 3.4 g of white crystals having a melting point of 108°-110° are obtained.

The 2-carbamoyl-nicotinic acid derivatives of formula VIII listed in Tables 8.00 to 8.02 are prepared in a manner analogous to that described in Example 16. ##STR58##

                                      TABLE 8.00                                   __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     8.0001                                                                             H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0002                                                                             H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0003                                                                             H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0004                                                                             H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0005                                                                             H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0006                                                                             H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0007                                                                             H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0008                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0009                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0010                                                                             H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0011                                                                             H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0012                                                                             H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0013                                                                             H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0014                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0015                                                                             H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0016                                                                             H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0017                                                                             H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0018                                                                             H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0019                                                                             H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0020                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0021                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0022                                                                             H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0023                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0024                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0025                                                                             H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0026                                                                             H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0027                                                                             H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0028                                                                             H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0029                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0030                                                                             H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0031                                                                             H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0032                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                8.0033                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub. 5 (cyclo)                               __________________________________________________________________________

                                      TABLE 8.01                                   __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z     phys. data                                       __________________________________________________________________________     8.0101                                                                             H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0102                                                                             H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0103                                                                             H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0104                                                                             H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0105                                                                             H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0106                                                                             H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0107                                                                             H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0108                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0109                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0110                                                                             H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0111                                                                             H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0112                                                                             H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0113                                                                             H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0114                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0115                                                                             H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0116                                                                             H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0117                                                                             H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0118                                                                             H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0119                                                                             H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0120                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0121                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub. 2 OC.sub.2 H.sub.5                             8.0122                                                                             H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0123                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0124                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0125                                                                             H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0126                                                                             H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0127                                                                             H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0128                                                                             H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0129                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0130                                                                             H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0131                                                                             H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0132                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              8.0133                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              __________________________________________________________________________

                                      TABLE 8.02                                   __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z     phys. data                                       __________________________________________________________________________     8.0101                                                                             H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0202                                                                             H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0203                                                                             H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0204                                                                             H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0205                                                                             H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0206                                                                             H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0207                                                                             H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0208                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0209                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0210                                                                             H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0211                                                                             H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0212                                                                             H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0213                                                                             H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0214                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0215                                                                             H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0216                                                                             H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0217                                                                             H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0218                                                                             H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0219                                                                             H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0220                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0221                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub. 2 OC.sub.6 H.sub.5                             8.0222                                                                             H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0223                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0224                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0225                                                                             H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0226                                                                             H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0227                                                                             H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0228                                                                             H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0229                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0230                                                                             H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0231                                                                             H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0232                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              8.0233                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              __________________________________________________________________________

EXAMPLE 17 Preparation of 2-(N-valylnitrile)carbamoyl-6-phenoxymethyl-nicotinic acid ##STR59##

1.2 g of 2-methylvalylnitrile (2-amino-2-isopropyl-2-methyl-acetonitrile) are added to a solution of 2.55 g of 6-phenoxymethylpyridine-2,3-dicarboxylic acid anhydride in 3.0 ml of tetrahydrofuran while stirring and the reaction mixture is further stirred for one hour at room temperature before being concentrated by evaporation in vacuo. The residue is triturated in a small amount of ether and crystallises. In this manner 3.2 g of the above nicotinic acid with a melting point of 82°-87° are obtained.

The nicotinic acid derivatives of formula IX listed in Tables 9.00 to 9.02 are prepared analogously to Example 18. ##STR60##

                                      TABLE 9.00                                   __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     9.0001                                                                             H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0002                                                                             H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0003                                                                             H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0004                                                                             H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0005                                                                             H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0006                                                                             H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0007                                                                             H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0008                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0009                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0010                                                                             H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0011                                                                             H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0012                                                                             H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0013                                                                             H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0014                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0015                                                                             H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0016                                                                             H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0017                                                                             H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0018                                                                             H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0019                                                                             H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0020                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0021                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0022                                                                             H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0023                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0024                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0025                                                                             H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0026                                                                             H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0027                                                                             H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0028                                                                             H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0029                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0030                                                                             H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0031                                                                             H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0032                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                9.0033                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub. 5 (cyclo)                               __________________________________________________________________________

                                      TABLE 9.01                                   __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z     phys. data                                       __________________________________________________________________________     9.0101                                                                             H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0102                                                                             H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0103                                                                             H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0104                                                                             H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0105                                                                             H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0106                                                                             H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0107                                                                             H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0108                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0109                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0110                                                                             H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0111                                                                             H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0112                                                                             H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0113                                                                             H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0114                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0115                                                                             H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0116                                                                             H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0117                                                                             H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0118                                                                             H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0119                                                                             H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0120                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0121                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub. 2 OC.sub.2 H.sub.5                             9.0122                                                                             H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0123                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0124                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0125                                                                             H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0126                                                                             H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0127                                                                             H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0128                                                                             H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0129                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0130                                                                             H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0131                                                                             H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0132                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              9.0133                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              __________________________________________________________________________

                                      TABLE 9.02                                   __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z     phys. data                                       __________________________________________________________________________     9.0201                                                                             H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                                                            m.p. 82-87°                               9.0202                                                                             H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0203                                                                             H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0204                                                                             H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0205                                                                             H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0206                                                                             H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0207                                                                             H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0208                                                                             H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0209                                                                             H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0210                                                                             H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0211                                                                             H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0212                                                                             H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0213                                                                             H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0214                                                                             H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0215                                                                             H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0216                                                                             H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0217                                                                             H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0218                                                                             H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0219                                                                             H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0220                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0221                                                                             H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub. 7 (iso)                                                              CH.sub.2 OC.sub.6 H.sub.5                              9.0222                                                                             H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0223                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0224                                                                             H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0225                                                                             H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0226                                                                             H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0227                                                                             H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0228                                                                             H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0229                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0230                                                                             H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0231                                                                             H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0232                                                                             H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              9.0233                                                                             H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              __________________________________________________________________________

EXAMPLE 18 Preparation of N-(2-isopropyl-2-methyl-glycylnitrile)-6-phenoxymethylpyridine-2,3-dicarboxylic acid imide ##STR61##

0.02 parts of sodium acetate is added to a solution of one part of 2-(N-valylnitrile)carbamoyl-6-phenoxymethylnicotinic acid (Example 17) in 4 parts of acetic anhydride and the mixture is stirred under reflux for 6 hours at 110°. It is then concentrated by evaporation and the residue is taken up in some toluene and again concentrated by evaporation.

The residue is triturated in ether/hexane, and the resulting crystalline mass is filtered off with suction, then dissolved in methylene chloride and filtered on silica gel. After evaporation of the methylene chloride 0.85 parts of the above imide remain.

The pyridine-2,3-dicarboxylic acid imides of formula X listed in Tables 10.00 to 10.02 are prepared in a manner analogous to that described in Example 18. ##STR62##

                                      TABLE 10.00                                  __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     10.0001                                                                            H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0002                                                                            H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0003                                                                            H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0004                                                                            H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0005                                                                            H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0006                                                                            H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0007                                                                            H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0008                                                                            H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0009                                                                            H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0010                                                                            H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0011                                                                            H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0012                                                                            H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0013                                                                            H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0014                                                                            H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0015                                                                            H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0016                                                                            H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0017                                                                            H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0018                                                                            H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0019                                                                            H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0020                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0021                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0022                                                                            H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0023                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0024                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0025                                                                            H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0026                                                                            H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0027                                                                            H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0028                                                                            H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0029                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0030                                                                            H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0031                                                                            H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0032                                                                            H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                10.0033                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub. 5 (cyclo)                               __________________________________________________________________________

                                      TABLE 10.01                                  __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     10.0101                                                                            H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0102                                                                            H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0103                                                                            H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0104                                                                            H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0105                                                                            H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0106                                                                            H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0107                                                                            H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0108                                                                            H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0109                                                                            H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0110                                                                            H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0111                                                                            H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0112                                                                            H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0113                                                                            H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0114                                                                            H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0115                                                                            H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0116                                                                            H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0117                                                                            H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0118                                                                            H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0119                                                                            H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0120                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0121                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub. 2 OC.sub.2 H.sub.5                             10.0122                                                                            H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0123                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0124                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0125                                                                            H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0126                                                                            H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0127                                                                            H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0128                                                                            H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0129                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0130                                                                            H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0131                                                                            H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0132                                                                            H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              10.0133                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              __________________________________________________________________________

                                      TABLE 10.02                                  __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     10.0201                                                                            H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0202                                                                            H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0203                                                                            H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0204                                                                            H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0205                                                                            H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0206                                                                            H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0207                                                                            H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0208                                                                            H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0209                                                                            H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0210                                                                            H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0211                                                                            H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0212                                                                            H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0213                                                                            H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0214                                                                            H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0215                                                                            H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0216                                                                            H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0217                                                                            H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0218                                                                            H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0219                                                                            H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0220                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0221                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub. 2 OC.sub.6 H.sub.5                             10.0222                                                                            H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0223                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0224                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0225                                                                            H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0226                                                                            H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0227                                                                            H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0228                                                                            H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0229                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0230                                                                            H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0231                                                                            H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0232                                                                            H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              10.0233                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              __________________________________________________________________________

EXAMPLE 19 Preparation of N-(2-methylvalylamide)-6-phenoxymethylpyridine-2,3-carboxylic acid imide ##STR63##

While stirring, and maintaining the reaction temperature below 70° by cooling, one part of 2-phenoxymethyl-5,7-dihydro-α-isopropyl-α-methyl-5,7-dioxo-OH-pyrrolo[3,4-6]pyridine-6-acetonitrile [N-(2-isopropyl-2-methylglycylnitrile)-6-phenoxymethylpyridine-2,3-dicarboxylic acid imide of Example 18] is added to one part of concentrated sulphuric acid. When the addition is complete, the reaction mixture is further stirred for one hour at 65°, then cooled, and poured onto 12 parts of ice. 1.5 parts of sodium acetate are added to the resulting mixture while stirring and, after 2 hours, the mixture is filtered with suction. The filtration residue is washed with sodium acetate solution and water and dried over phosphorus pentoxide. In this manner 0.82 parts of the above imide are obtained.

The pyridine-2,3-dicarboxylic acid imides of formula XI listed in Tables 11.00 to 11.02 are prepared in a manner analogous to that described in Example 19. ##STR64##

                                      TABLE 11.00                                  __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     11.0001                                                                            H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0002                                                                            H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0003                                                                            H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0004                                                                            H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0005                                                                            H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0006                                                                            H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0007                                                                            H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0008                                                                            H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0009                                                                            H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0010                                                                            H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0011                                                                            H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0012                                                                            H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0013                                                                            H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0014                                                                            H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0015                                                                            H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0016                                                                            H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0017                                                                            H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0018                                                                            H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0019                                                                            H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0020                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0021                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0022                                                                            H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0023                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0024                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0025                                                                            H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0026                                                                            H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0027                                                                            H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0028                                                                            H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0029                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0030                                                                            H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0031                                                                            H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0032                                                                            H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                11.0033                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub. 5 (cyclo)                               __________________________________________________________________________

                                      TABLE 11.01                                  __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     11.0101                                                                            H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0102                                                                            H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0103                                                                            H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0104                                                                            H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0105                                                                            H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0106                                                                            H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0107                                                                            H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0108                                                                            H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0109                                                                            H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0110                                                                            H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0111                                                                            H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0112                                                                            H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0113                                                                            H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0114                                                                            H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0115                                                                            H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0116                                                                            H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0117                                                                            H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0118                                                                            H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0119                                                                            H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0120                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0121                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub. 2 OC.sub.2 H.sub.5                             11.0122                                                                            H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0123                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0124                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0125                                                                            H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0126                                                                            H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0127                                                                            H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0128                                                                            H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0129                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0130                                                                            H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0131                                                                            H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0132                                                                            H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              11.0133                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              __________________________________________________________________________

                                      TABLE 11.02                                  __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     11.0201                                                                            H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0202                                                                            H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0203                                                                            H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0204                                                                            H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0205                                                                            H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0206                                                                            H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0207                                                                            H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0208                                                                            H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0209                                                                            H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0210                                                                            H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0211                                                                            H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0212                                                                            H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0213                                                                            H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0214                                                                            H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0215                                                                            H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0216                                                                            H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0217                                                                            H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0218                                                                            H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0219                                                                            H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0220                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0221                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub. 2 OC.sub.6 H.sub.5                             11.0222                                                                            H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0223                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0224                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0225                                                                            H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0226                                                                            H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0227                                                                            H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0228                                                                            H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0229                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0230                                                                            H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0231                                                                            H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0232                                                                            H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              11.0233                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              __________________________________________________________________________

EXAMPLE 20 Preparation of 3-isopropyl-3-methyl-8-phenoxymethyl-1H-imidazo[1',2':1,2]pyrrolo[3,4-6]pyridine-2,5(3H, 96H)-dione. ##STR65##

1 part of N-(2-methylvalylamide)-6-phenoxymethylpyridine-2,3-dicarboxylic acid imide (Example 19) are dissolved in 9 parts of toluene and the solution is boiled on a water separator for 15 hours. It is then cooled and 0.2 parts of a 50% sodium hydride mineral oil suspension are added to the dry toluene solution. The suspension is boiled at reflux for 24 hours and filtered while still hot. The solution is then concentrated by evaporation and the crystalline precipitate is freed of mineral oil using hexane and then dried in vacuo. In this manner 0.78 parts of the above tricyclic compound are obtained.

The tricyclic compounds of formula XII listed in Tables 12.00 to 12.02 are prepared in a manner analogous to that described in Example 20. ##STR66##

                                      TABLE 12.00                                  __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     12.0001                                                                            H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0002                                                                            H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0003                                                                            H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0004                                                                            H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0005                                                                            H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0006                                                                            H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0007                                                                            H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0008                                                                            H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0009                                                                            H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0010                                                                            H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0011                                                                            H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0012                                                                            H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0013                                                                            H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0014                                                                            H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0015                                                                            H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0016                                                                            H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0017                                                                            H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0018                                                                            H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0019                                                                            H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0020                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0021                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0022                                                                            H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0023                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0024                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0025                                                                            H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0026                                                                            H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0027                                                                            H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0028                                                                            H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0029                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0030                                                                            H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0031                                                                            H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0032                                                                            H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub.5 (cyclo)                                12.0033                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               C.sub.3 H.sub. 5 (cyclo)                               __________________________________________________________________________

                                      TABLE 12.01                                  __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     12.0101                                                                            H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0102                                                                            H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0103                                                                            H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0104                                                                            H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0105                                                                            H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0106                                                                            H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0107                                                                            H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0108                                                                            H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0109                                                                            H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0110                                                                            H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0111                                                                            H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0112                                                                            H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0113                                                                            H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0114                                                                            H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0115                                                                            H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0116                                                                            H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0117                                                                            H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0118                                                                            H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0119                                                                            H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0120                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0121                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub. 2 OC.sub.2 H.sub.5                             12.0122                                                                            H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0123                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0124                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0125                                                                            H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0126                                                                            H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0127                                                                            H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0128                                                                            H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0129                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0130                                                                            H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0131                                                                            H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0132                                                                            H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              12.0133                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.2 H.sub.5                              __________________________________________________________________________

                                      TABLE 12.02                                  __________________________________________________________________________     No. X Y         R.sub.2                                                                           R.sub.3                                                                             Z      phys. data                                      __________________________________________________________________________     12.0201                                                                            H H         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0202                                                                            H CH.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0203                                                                            H C.sub.2 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0204                                                                            H C.sub.3 H.sub.7                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0205                                                                            H OCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0206                                                                            H OC.sub.2 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0207                                                                            H OCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0208                                                                            H OCH.sub.2 CH═CHCH.sub.3                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0209                                                                            H OCH.sub.2 C(Cl)═CH.sub.2                                                             CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0210                                                                            H OCH.sub.2 CH═CHCl                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0211                                                                            H OCH.sub.2 C.tbd.CH                                                                       CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0212                                                                            H OCHF.sub.2                                                                               CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0213                                                                            H OCF.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0214                                                                            H OCF.sub.2 CHFCF.sub.3                                                                    CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0215                                                                            H OC.sub.6 H.sub.5                                                                         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0216                                                                            H CF.sub.3  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0217                                                                            H Br        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0218                                                                            H Cl        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0219                                                                            H F         CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0220                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0221                                                                            H SCH.sub.3 CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub. 2 OC.sub.6 H.sub.5                             12.0222                                                                            H SC.sub.3 H.sub.7 -n                                                                      CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0223                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0224                                                                            H SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0225                                                                            H NO.sub.2  CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0226                                                                            H CN        CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0227                                                                            H CH.sub.2 OH                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0228                                                                            H CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0229                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 OH                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0230                                                                            H C.sub.6 H.sub.5                                                                          CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0231                                                                            H CH.sub.2 Cl                                                                              CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0232                                                                            H CH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              12.0233                                                                            H CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                          C.sub.3 H.sub.7 (iso)                                                               CH.sub.2 OC.sub.6 H.sub.5                              __________________________________________________________________________

Formulation Examples

EXAMPLE 21 Formulation Examples for the active ingredients of formula I (%=percent by weight)

    ______________________________________                                         (a) Wettable powders                                                                              (a)      (b)    (c)                                         ______________________________________                                         an active ingredient according                                                                    20%      60%     0.5%                                       to Tables 1 to 4                                                               sodium lignosulphonate                                                                             5%       5%      5%                                        sodium laurylsulphate                                                                              3%      --     --                                          sodium diisobutylnaph-                                                                            --        6%      6%                                        thalenesulphonate                                                              octylphenol polyethylene                                                                          --        2%      2%                                        glycol ether (7-8 moles                                                        of ethylene oxide)                                                             highly dispersed    5%      27%      27%                                       silicic acid                                                                   kaolin             67%      --     59.5%                                       ______________________________________                                    

The active ingredient is thoroughly mixed with the adjuvants and the mixture is thoroughly ground in a suitable mill, affording wettable powders which can be diluted with water to give suspensions of the desired concentration.

    ______________________________________                                         (b) Emulsifiable concentrate                                                                         (a)    (b)                                               ______________________________________                                         an active ingredient according                                                                       10%     1%                                               to Tables 1 to 4                                                               octylphenol polyethylene                                                                              3%     3%                                               glycol ether (4-5 moles of                                                     ethylene oxide)                                                                calcium dodecylbenzene-                                                                               3%     3%                                               sulphonate                                                                     castor oil polyglycol ether                                                                           4%     4%                                               (36 moles of ethylene oxide)                                                   cyclohexanone         30%    10%                                               xylene mixture        50%    79%                                               ______________________________________                                    

Emulsions of any required concentration can be obtained from this by dilution with water.

    ______________________________________                                         (c) Dusts            (a)     (b)                                               ______________________________________                                         an active ingredient according                                                                       0.1%    1%                                               to Tables 1 to 4                                                               talcum               99.9%   --                                                kaolin               --      99%                                               ______________________________________                                    

Ready-for-use dusts are obtained by mixing the active ingredient with the carrier and grinding the mixture in a suitable mill.

    ______________________________________                                         (d) Extruder granulate                                                                              (a)    (b)                                                ______________________________________                                         an active ingredient according                                                                      10%    1%                                                 to Tables 1 to 4                                                               sodium lignosulphonate                                                                               2%    2%                                                 carboxymethylcellulose                                                                               1%    1%                                                 kaolin               87%    96%                                                ______________________________________                                    

The active ingredient is mixed and ground with the adjuvants, and the mixture is moistened with water. The mixture is extruded and then dried in a stream of air.

    ______________________________________                                         (e) Coated granulate                                                           ______________________________________                                         an active ingredient according                                                                       3%                                                       to Tables 1 to 4                                                               polyethylene glycol (MW 200)                                                                         3%                                                       kaolin               94%                                                       ______________________________________                                    

The finely ground active ingredient is uniformly applied, in a mixer, to the kaolin moistened with polyethylene glycol. Dust-free coated granulates are obtained in this manner.

    ______________________________________                                         (f) Suspension concentrate                                                                            (a)    (b)                                              ______________________________________                                         an active ingredient according                                                                         40%     5%                                             to Tables 1 to 4                                                               ethylene glycol         10%    10%                                             nonylphenol polyethylene glycol                                                                         6%     1%                                             ether (15 moles of ethylene oxide)                                             sodium lignosulphonate  10%     5%                                             carboxymethylcellulose   1%     1%                                             37% aqueous formaldehyde solution                                                                     0.2%   0.2%                                             silicone oil in the form of a                                                                         0.8%   0.8%                                             75% aqueous emulsion                                                           water                   32%    77%                                             ______________________________________                                    

The finely ground active ingredient is homogeneously mixed with the adjuvants, giving a suspension concentrate from which suspensions of any desired concentration can be obtained by dilution with water.

Biological Examples

EXAMPLE 22 Pre-emergence herbicidal action

Directly after the test plants have been sown in seed trays in a greenhouse the surface of the soil is treated with an aqueous dispersion of the active ingredients, obtained from a 25% emulsifiable concentrate. Concentrations of 4 kg of active ingredient/hectare are used. The seed trays are kept in the greenhouse at 22° to 25° C. and 50 to 70% relative humidity and the test is assessed after three weeks, the results being evaluated in accordance with the following scale:

    ______________________________________                                         1         plant has not germinated or has withered                             2-3       very pronounced damage                                               4         pronounced damage                                                    5         moderate damage, the plants are stunted                              6         damage which the plant can regenerate                                8-8       slight damage                                                        9         normal growth, like the untreated plant                              ______________________________________                                    

In this test the compounds of Tables 1 to 4 exhibited a strong herbicidal action.

EXAMPLE 23 Post-emergence herbicidal action (contact herbicide)

A number of weeds, both monocotyledonous and dicotyledonous, were sprayed post-emergence (in the 4- to 6-leaf stage) with an aqueous dispersion of active ingredient at a rate of 4 kg of active ingredient per hectare, and maintained at 24° to 26° C. and 45 to 60% relative humidity. 15 days after the treatment the test is evaluated in accordance with the above scale. In this test too, the compounds of Tables 1 to 4 exhibit a strong to very strong herbicidal action.

EXAMPLE 24 Pre-emergence herbicidal action

Plastics pots are filled with expanded vermiculite (density: 0.135 g/cm³, water-absorbing capacity: 0.565 l/l). After the non-adsorptive vermiculite has been saturated with an aqueous emulsion of the active ingredient, seeds of the following plants are sown on the surface: Nasturtium officinalis, Agrostis tenuis, Stellaria media and Digitaria sanguinalis. The pots are then kept in a climatic chamber at 20° C., an illumination of about 20 klux and a relative humidity of 70%. During the germination phase of from 4 to 6 days, the pots are covered with light-permeable material in order to increase the local humidity and watered with deionised water. After the 5th day 0.5% of a commercial liquid fertilizer (®Greenzit) is added to the water. The test is evaluated 12 days after sowing and the action on the test plants is assessed according to the scale given in Example 3.

The results are compiled in Table 13:

                  TABLE 13                                                         ______________________________________                                               rate of                                                                        applica-                                                                 Comp. tion     Nasturtium                                                                               Agrostis                                                                              Stellaria                                                                             Digitaria                               No.   ppm      officinalis                                                                              tenuis media  sang.                                   ______________________________________                                         1.0003                                                                               100      2         2      2      2                                       1.0402                                                                               100      2         1      2      2                                       2.0001                                                                               100      2         2      2      2                                       2.0002                                                                               100      2         2      2      2                                       2.0003                                                                               100      2         2      2      2                                       2.0017                                                                               100      1         1      1      1                                       2.0034                                                                               100      2         3      4      4                                       2.0301                                                                               100      2         2      2      2                                       2.0401                                                                               100      2         2      2      2                                       2.0402                                                                               100      2         2      2      2                                       2.0403                                                                               100      2         2      2      2                                       2.0434                                                                               100      8         8      8      8                                       2.0601                                                                               100      2         2      2      2                                       2.0602                                                                               100      2         2      2      2                                       2.0603                                                                               100      2         2      2      2                                       2.1001                                                                               100      2         2      2      2                                       2.1201                                                                               100      4         4      3      4                                       2.1301                                                                               100      2         2      2      2                                       2.1401                                                                               100      3         3      3      3                                       2.1601                                                                               100      6         6      6      7                                       3.0002                                                                               100      1         1      2      2                                       3.0403                                                                               100      2         2      2      2                                       4.0002                                                                               100      3         3      3      3                                       4.0003                                                                               100      2         2      2      2                                       4.0403                                                                               100      2         2      2      2                                       4.1001                                                                               100      2         2      2      2                                       ______________________________________                                    

EXAMPLE 25 Herbicidal action for paddy rice

The water weeds Echinochloa crus galli and Monochari vag. are sown in plastics beakers (surface area 60 cm², volume 500 ml). After sowing, the beakers are filled with water up to the surface of the soil. 3 days after sowing, the water level is raised to slightly above (3-5 mm) the surface of the soil. Application is effected 3 days after sowing by spraying the beakers with an aqueous emulsion of the test substances. The dose corresponds to an amount of active ingredient of 4 kg per hectare (quantity of spray mixture: 550 l/ha). The beakers are then kept in the greenhouse under optimum growth conditions for rice weeds, i.e. at 25° to 30° C. and at high humidity. The evaluation of the tests takes place 3 weeks after application.

The assessment is carried out in accordance with the linear scale given in Example 22.

The tested compounds of Tables 1 to 4 exhibit a good action against these weeds with the rice plantlets to a large extent being preserved.

EXAMPLE 26 Growth inhibition of tropical cover crops

The test plants (Centrosema plumieri and Centrosema pubescens) are reared until fully grown and then cut back to a height of 60 cm. The plants are sprayed 7 days later with an aqueous emulsion of the active ingredient. The test plants are kept at 70% relative humidity and 6000 lux artifical light for 14 hours per day at day temperatures of 27° C. and night temperatures of 21° C. The test is evaluated 4 weeks after application by assessing and weighing the new growth compared with controls and by determining the phytotoxicity. In this test a marked reduction in new growth (less than 20% of the new growth of untreated control plants) of the plants treated with the active ingredients of Table 1 at application rates of 50-3000 g/ha is observed without at the same time the test plants being damaged.

EXAMPLE 27 Growth regulation of soybeans

Soybeans of the "Hark" variety are sown in plastics containers containing an earth/peat/sand mixture in a ratio of 6:3:1 and placed in a climatic chamber. As a result of optimum choice of temperature, illumination, addition of fertilizer and watering, the plants have developed to the 5 to 6 trefoil leaf stage after about 5 weeks. The plants are then sprayed with an aqueous mixture of an active ingredient of formula I until thoroughly wet. The concentration of active ingredient is up to 100 g a.i./ha. The evaluation is carried out about 5 weeks after application of the active ingredient. Compared with untreated control plants, active ingredients according to the invention of Table 1 cause a marked increase in the number and weight of the siliques on the leading shoot.

EXAMPLE 28 Growth inhibition of cereals

Hordeum vulgare (summer barley) and Secale (summer rye) are sown according to cereal type in a greenhouse in plastics pots containing sterilised soil and watered as required. The shoots are sprayed about 21 days after sowing with an aqueous spray mixture of an active ingredient of Table 1. The amount of active ingredient is up to 100 g per hectare. 21 days after the application the growth of the cereal is assessed. Compared with untreated controls, the treated plants exhibit a reduction in new growth (60-90% of the control) and also, in some cases, an increase in the stalk diameter.

EXAMPLE 29 Growth inhibition of grasses

The grasses Lolium perenne, Poa pratensis, Festuca ovina, Dactylis glomerate and Cynodon dactylon are sown in a greenhouse in plastics trays containing an earth/peat/sand mixture (6:3:1) and watered as required. The grasses are cut back weekly to a height of 4 cm and, about 50 days after sowing and one day after the last cut, sprayed with an aqueous spray mixture of an active ingredient of Tables 3 to 8. The amount of active ingredient corresponds to up to 500 g of active ingredient per hectare. 21 days after application the growth of the grasses is assessed.

The tested compounds of Table 1 cause a reduction in new growth of about 10 to 30% in comparison with untreated controls.

EXAMPLE 30 Dessication and defoliation activity

Cotton plants of the Deltapine variety were sown in clay pots in a greenhouse. When capsule formation was complete they were sprayed with aqueous preparations of the active ingredients at a rate of application that would correspond to 1.2, 0.6 and 0.3 kg/ha in the field. Untreated plants were used as controls. The evaluation of the test was carried out 3, 7 and 14 days after application of the active substance by determining the degree of defoliation (% of leaves that had fallen) and of dessication (% drying out of the leaves left on the plants).

In this test, at rates of application of 0.6 and 1.2 kg/ha, the tested compounds of Table 1 left only few dried leaves on the plants (>80% leaf fall and dessication). 

We claim:
 1. A process for the preparation of a 6-substituted 2-(imidazolin-2-yl)-nicotinic acid of the formula III ##STR67## in which R₂ is C₁ -C₄ -alkyl;R₃ is C₁ -C₄ -alkyl or C₃ -C₆ -cycloalkyl; or R₂ and R₃, together with the carbon atom to which they are bonded, also represent a C₃ -C₆ -cycloalkyl radical which may be substituted by methyl radicals; X is hydrogen or methyl; Y is hydrogen; halogen; C₁ -C₆ -alkyl; C₁ -C₆ -haloalkyl; C₁ -C₆ -hydroxyalkyl; C₁ -C₆ -alkoxy; C₁ -C₆ -alkylthio; phenoxy; nitro; cyano; C₁ -C₄ -alkylamino; di-C₁ -C₄ -alkylamino; C₁ -C₄ -alkylsulphonyl; phenyl; halophenyl; lower alkylphenyl; lower alkoxyphenyl; C₃ -C₈ -alkenyloxy; C₃ -C₈ -haloalkenyloxy; C₃ -C₈ -alkynyloxy or C₃ -C₈ -haloalkynyloxy; and Z is a --CQ₁ Q₂ Q₃ or --CQ₁ Q₄ Q₅ radical in which Q₁ is hydrogen or C₁ -C₄ -alkyl; Q₂ is hydrogen or C₁ -C₄ -alkyl; Q₃ is C₁ -C₆ -alkoxy that is unsubstituted or is substituted by C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₄ -C₉ -alkoxyalkoxy, cyano or by carbamoyl; phenoxy that is unsubstituted or is substituted by halogen, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl or by nitro; or C₃ -C₆ -alkenyloxy or C₃ -C₆ -alkynyloxy; Q₄ and Q₅, together with the carbon atom to which they are bonded, represent C₃ -C₆ -cycloalkyl; or a 5- or 6-membered ring containing one oxygen atom or two oxygen atoms that are not vicinal, each of which radicals may be substituted by C₁ -C₄ -alkyl; or Z is a 5- or 6-membered, saturated or unsaturated, heterocyclic radical that is bonded by way of carbon and is unsubstituted or is substituted by lower alkyl; which consists in reacting a pyridine-2,3-dicarboxylic acid diester of the formula V ##STR68## in which X and Y are as defined above; R₁ is hydrogen; the cation equivalent of an alkali metal, alkaline earth metal, magnesium, copper, iron, zinc, cobalt, lead, silver, nickel or quaternary ammonium or alkylammonium salt; C₁ -C₆ -alkyl unsubstituted or substituted by halogen, hydroxy, C₁ -C₃ -alkoxy, C₃ -C₆ -cycloalkyl, benzyloxy, furyl, phenyl, halophenyl, lower alkylphenyl, lower alkoxyphenyl, nitrophenyl, carboxy, C₁ -C₄ -alkoxycarbonyl or by cyano; C₃ -C₆ -cycloalkyl unsubstituted or mono- or di-substituted by C₁ -C₃ -alkyl; C₃ -C₆ -alkenyl unsubstituted or substituted by halogen, C₁ -C₃ -alkoxy, phenyl or by C₁ -C₄ -alkoxycarbonyl; or C₃ -C₆ -alkynyl unsubstituted or mono- or di-substituted by C₁ -C₃ -alkyl and R₄ is a C₁ -C₃ alkyl radical; a C₁ -C₈ -alkylphenyl radical or a phenyl-C₁ -C₄ -alkyl radical; in aqueous solution at a temperature of between room temperature and the boiling point of the reaction mixture, under atmospheric pressure, in the presence of a catalytic amount of silver (II) ions and a peroxysulphate salt, with a carboxylic acid of the formula XVII

    Z--COOH                                                    (XVII),

in which Z is as defined above, and reacting the resulting 6-substituted pyridine-2,3-dicarboxylic acid diester of the formula IV ##STR69## in an inert organic solvent, in the presence of a strong base at temperature of between room temperature and the boiling point of the reaction mixture under atomospheric pressure, with a 2-aminoalkanecarboxylic acid amide of formula XV ##STR70## in which R₂ and R₃ are as defined above, and the resulting salt of the 2-(imidazolin-2-yl)-nicotinic acid of formula III is taken up in aqueous acidic solution to form the free 6-substituted-2-(imidazolin-2-yl)-nicotinic acid of formula III.
 2. A process of claim 1 in which R₁ is hydrogen or C₁ -C₆ -alkyl; Y is hydrogen, C₁ -C₆ -alkyl or halogen; Z is a heterocyclic radical or, if it is --CQ₁ Q₂ Q₂ Q₃, is a C₁ -C₆ -alkoxy-C₁ -C₄ -alkyl-, phenoxy-C₁ -C₄ -alkyl or carbamoyl-C₁ -C₄ -alkoxy-C₁ -C₄ -alkyl radical or, if it is --CQ₁ Q₄ Q₅, is a C₃ -C₆ -cycloalkyl radical or a C₃ -C₆ -cycloalkyl radical that may be substituted by C₁ -C₄ -alkyl. 